Lactate and pyruvate concentrations in capillary blood from newborns

Nielsen, Jens; Ytrebø, L.M.; Borud, O.

doi:10.1111/j.1651-2227.1994.tb13171.x

Cited by 15 publications

(8 citation statements)

References 5 publications

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“…41 Furthermore, capillary blood lactate concentrations differ little from arterial concentrations in ill neonates 42. This would allow capillary blood samples to be used extensively for blood lactate measurements in ill infants.…”

Section: Discussionmentioning

confidence: 98%

Association between blood lactate and acid-base status and mortality in ventilated babies

Deshpande

Platt

1997

Archives of Disease in Childhood - Fetal and Neonatal Edition

165

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Section: Discussionmentioning

confidence: 98%

Association between blood lactate and acid-base status and mortality in ventilated babies

Deshpande

Platt

1997

Archives of Disease in Childhood - Fetal and Neonatal Edition

165

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“…Under aerobic conditions glucose is metabolized through the glycolytic pathway and penetrates in the mitochondria where pyruvate is converted to acetyl coenzyme A, enters the tricarboxylic acid cycle and couples to the respiratory chain yielding energy in the form of adenosine triphosphate through oxidative phosphorylation 30 . In capillary blood drawn on day 4 from healthy full-term newborns, lactate and pyruvate were reported to range between 367 and 3245 and 10 and 141 μmol L −1 , respectively 31 . In this study, for healthy term newborns at two days of age ranges (percentile 10 to 90) between 300 and 1000 and 6 and 50 μmol L −1 (see Table 4 ) were obtained for lactate and pyruvate, respectively.…”

Section: Discussionmentioning

confidence: 99%

Evolution of Energy Related Metabolites in Plasma from Newborns with Hypoxic-Ischemic Encephalopathy during Hypothermia Treatment

Sánchez-Illana¹,

Núñez-Ramiro²,

Cernada³

et al. 2017

Sci Rep

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Therapeutic hypothermia (TH) initiated within 6 h from birth is the most effective therapeutic approach for moderate to severe hypoxic-ischemic encephalopathy (HIE). However, underlying mechanisms and effects on the human metabolism are not yet fully understood. This work aims at studying the evolution of several energy related key metabolites in newborns with HIE undergoing TH employing gas chromatography – mass spectrometry. The method was validated following stringent FDA requirements and applied to 194 samples from a subgroup of newborns with HIE (N = 61) enrolled in a multicenter clinical trial (HYPOTOP) for the determination of lactate, pyruvate, ketone bodies and several Krebs cycle metabolites at different sampling time points. The analysis of plasma samples from newborns with HIE revealed a decrease of lactate, pyruvate and β-hydroxybutyrate concentrations, whereas rising malate concentrations were observed. In healthy control newborns (N = 19) significantly lower levels of pyruvate and lactate were found in comparison to age-matched newborns with HIE undergoing TH, whereas acetoacetate and β-hydroxybutyrate levels were clearly increased. Access to a validated analytical method and a controlled cohort of newborns with HIE undergoing hypothermia treatment for the first time allowed the in-depth study of the evolution of key metabolites of metabolic junctions in this special population.

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“…There is strong evidence from the literature for a good correlation between lactate measurements in arterial and central venous or mixed venous blood samples (14), and between arterial and peripheral venous blood lactate concentrations (15). Several authors have established normal values for capillary lactate concentrations in term and preterm infants (16,17). The availability of bedside lactate measurement in neonatal intensive care units (NICUs) has led to an increased determination of capillary lactate concentration.…”

mentioning

confidence: 99%

Agreement between capillary and arterial lactate in the newborn

et al. 2002

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Fauchère J-C, Bauschatz AS, Arlettaz R, Zimmermann-Bär U, Bucher HU. Agreement between capillary and arterial lactate in the newborn. Acta Paediatr 2002; 91: 78-81. Stockholm. ISSN 0803-5253Arterial blood lactate is a reliable indicator of tissue oxygen debt and is of value in expressing the degree and prognosis of circulatory failure as a result of various diseases. Therefore, the practical issue of whether capillary lactate measurements might be of equal value was investigated in newborns. In total, 193 simultaneous measurements of capillary and arterial blood lactate concentrations were performed in 25 newborn babies with an indwelling umbilical arterial catheter. A strong linear correlation was found between capillary and arterial lactate concentration (L cap = 1.02 L art ‡ 0.04; r = 0.98; p < 0.001). The mean difference was ¡0.08 mmol/l and the limits of agreement ( § 2 SD) were § 0.69 mmol/l (¡0.77 to 0.61 mmol/l).Conclusion: Our data show that capillary blood lactate measurements in newborn babies yield lactate concentrations equivalent to arterial measurements over a large concentration range.

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Lactate and pyruvate concentrations in capillary blood from newborns

Cited by 15 publications

References 5 publications

Association between blood lactate and acid-base status and mortality in ventilated babies

Association between blood lactate and acid-base status and mortality in ventilated babies

Evolution of Energy Related Metabolites in Plasma from Newborns with Hypoxic-Ischemic Encephalopathy during Hypothermia Treatment

Agreement between capillary and arterial lactate in the newborn

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