Lactate: Biomarker and Potential Therapeutic Target

Okorie, Okorie Nduka; Dellinger, Phil

doi:10.1016/j.ccc.2010.12.013

Cited by 166 publications

(142 citation statements)

References 79 publications

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“…Lactic acidosis is a common finding in diabetic ketoacidosis (DKA) and may be multi-factorial in origin, due to metformin use, D-lactate production in erythrocytes (discussed later) and L-lactate production due to increased anaerobic glycolysis [43]. Lactic acidosis has been described in association with hematological malignancies and solid tumors; proposed mechanisms include increased glycolytic activity of the tumor cells (Warburg effect), tumor tissue hypoxia and decreased clearance of lactate due to liver metastases [40,[44][45][46]. Lactic acidosis may be a presenting feature of phaeochromocytoma or an intra-operative complication during adrenalectomy for this condition; this is likely due to epinephrine-induced gluconeogenesis with elevation of plasma pyruvate levels and peripheral tissue ischaemia due to catecholamineinduced vasoconstriction [47,48].…”

Section: Causes and Classification Of Lactic Acidosismentioning

confidence: 99%

Lactic acidosis: an update

Seheult

Fitzpatrick

Boran

2017

Clinical Chemistry and Laboratory Medicine (CCLM)

100

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Lactate is one of the most crucial intermediates in carbohydrate and nonessential amino acid metabolism. The complexity of cellular interactions and metabolism means that lactate can be considered a waste product for one cell but a useful substrate for another. The presence of elevated lactate levels in critically ill patients has important implications for morbidity and mortality. In this review, we provide a brief outline of the metabolism of lactate, the pathophysiology of lactic acidosis, the clinical significance of D-lactate, the role of lactate measurement in acutely ill patients, the methods used to measure lactate in blood or plasma and some of the methodological issues related to interferences in these assays, especially in the case of ethylene glycol poisoning.

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Section: Causes and Classification Of Lactic Acidosismentioning

confidence: 99%

Lactic acidosis: an update

Seheult

Fitzpatrick

Boran

2017

Clinical Chemistry and Laboratory Medicine (CCLM)

100

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“…(17) Increases in arterial or central venous lactate level can also predict in-hospital mortality in a number of disorders, such as infection, sepsis, liver disease, trauma, and cardiac arrest. (18) Our study results showed no relationship between the hematocrit and serum lactate level. To ascertain the presence of tissue hypoxia as a result of early plasma leakage in patients with dengue infection, the hematocrit has to be determined.…”

Section: Discussionmentioning

confidence: 45%

Inverse correlation between serum albumin and serum lactate in adults with dengue

Mauleti

Suhendro

Nainggolan

et al. 2016

UnivMed

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BACKGROUNDDengue infection is an acute viral infection, in the natural history of which plasma leakage may occur, resulting in shock followed by tissue hypoxia, with death as the final outcome if not treated properly. The purpose of this study was to determine the correlation of the hematocrit, serum albumin concentration, and the presence of pleural effusion or ascites, with hyperlactatemia in adult dengue patients.

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“…James et al (1999), descreveram aumento da produção de lactato quando referiram que a liberação da adrenalina endógena promove o aumento da glicólise aeróbica, em virtude de estimular a bomba de Na+/-K ATPase celular. Além disso, a contenção física dos cães e a oclusão venosa realizada para a cateterização podem sugerir a elevação discreta do lactato sérico, devido ao aumento na atividade muscular e a lise eritrocitária (Hughes 2000, De Backer et al 2006; sistemas responsá- veis por 20 a 25% da produção do lactato sérico fisiológico orgânico (Okorie & Dellinger 2011). Fatores psicológicos, como a ansiedade, podem estar envolvidos no aumento do lactato sérico, como descreveram Rocha et al (2009) quando identificaram o aumento na concentração de lactato sérico e cortisol basal em atletas antes de uma prova de atletismo, justificando o aumento na liberação de catecolaminas e mobilização de energia orgânica como responsá-veis para o aumento do lactato sérico.…”

Section: Discussionunclassified

Valores de lactato sérico e sua correlação com parâmetros clínicos de cães saudáveis, mensurados durante atendimento ambulatorial veterinário

et al. 2016

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ABSTRACT.-Franco R.P., Massufaro C.R., Martineli J., Girotto C.H., Hirota I.N., Zache E. & Hataka A. 2016 The measurement of serum lactate is used in the medical routine as a prognosis marker of emergency patients. Its interpretation should not be done disconnectedly from the other clinical parameters once metabolical or environmental stress as well as restraint and/or manipulation of patients can interfere. Thus we tried to measure the levels of serum lactate and clinical parameters of healthy dogs, as their correlation during veterinarian outpatient clinical care. For that we evaluated 80 dogs, males and females, with age ranging from one to eight years, met for polyvalent annual revaccination. We considered to be healthy those dogs that had no clinical events in the last 60 days or alteration in physical exams, blood exam values and serum glycemia. We initially measured body weight, heart rate (HR) and respiratory (RR), capillary refill time, mucosa's coloring, rectal temperature (RT), peripheral temperature (PT) and the difference between RT and PT, Delta T°C. Finally we did the blood exam and the serum glycemia, as well as the serum lactate measurement. For that we used a portable lactimeter, using the blood sample taken from the cephalic vein. Furthermore, when there was correlation between the serum lactate values and the body weight, we divided the dogs according to the calculation of 33 and 66 percentile. Evaluated dogs showed average values of 18.3±12.1 kg of body weight and 3.0±1.9 of age; with HR of 126.6±29.1bpm, RR of 66±24mpm, RT of 38.9±0.4°C, PT of 31.5±1,0°C, Delta T°C of 7.3±1.0°C and serum lactate of 3.2±0.4mmol/L; with the latter showing range of 3.1-3.3mmol/L with 95% of reliability and significant correlation (p<0.05) between its values and the body weight (r=0.6) and the heart rate (r=0.4). The serum lactate values obtained were compared between the dogs' groups according to their body weight, showing distinguished differences between them. Thereby we concluded that the serum lactate values in dogs under outpatient care is 3.2mmol/L, with a trust gap of 3.1-3.3mmol/L, highlighting the influence that HR and body weight can have on its values.INDEX TERMS: Serum lactate, clinical parameters, dogs.

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Lactate: Biomarker and Potential Therapeutic Target

Cited by 166 publications

References 79 publications

Lactic acidosis: an update

Lactic acidosis: an update

Inverse correlation between serum albumin and serum lactate in adults with dengue

Valores de lactato sérico e sua correlação com parâmetros clínicos de cães saudáveis, mensurados durante atendimento ambulatorial veterinário

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