Lactate dehydrogenase and malate dehydrogenase: Potential antiparasitic targets for drug development studies

An Epigenetic Role of Mitochondria in Cancer

“…Malate dehydrogenase (MDH) catalyzes the reversible interconversion of malate and oxaloacetate and their transport [ 465 ], and it has unique pharmacological selective and specificity properties and can be used as the potential antiparasitic target for drug development [ 466 ]. For example, urine malate dehydrogenase 2 can be used as a biomarker for the early detection of non-small-cell lung cancer [ 467 ].…”

Vulgarisin-type diterpenoids from self-heal (Prunella vulgaris) and their neuroprotective effects against ischemia/reperfusion (I/R) via a mitochondria-related pathway

“…Monitoring the release of LDH could provide an evaluation of cell death and also the influence of environmental effects on cell viability. 37 As shown in Fig. 6B, the LDH levels of the OGD/R group were remarkably higher than the blank control group, while compound 3 significantly reduced the LDH level ( P < 0.001).…”

Comparative proteomics analyses of whey proteins from breastmilk collected from two ethnic groups in northeast China

“…Lactate dehydrogenases (LDH) is an enzyme in the cytosol of various eukaryotic and prokaryotic organisms. LDH can assist the interconversion of pyruvate and lactate and oxidize nicotinamide adenine dinucleotide (NADH) to NAD + , which is critical for cell survival and development ( Kayamba et al, 2021 ). As mentioned in Section 3.5 , TPI plays its catalytic role in glycolysis and gluconeogenesis, which may be a potential target for anticancer studies by inhibition of this pathway since glycolysis plays a central role in cancer energy metabolism ( Pekel & Ari, 2020 ).…”