Lactic acid bacteria activating innate immunity improve survival in bacterial infection model of silkworm

Advantages of the Silkworm As an Animal Model for Developing Novel Antimicrobial Agents

“…Furthermore, these infections were cured with the same antibiotics used clinically to cure these infections (Kaito et al, 2002; Hamamoto et al, 2004). Since then, silkworms have been utilized to study pathogenic bacterial toxins (Hossain et al, 2006); evaluate the target specificity of antibacterial agents (Kurokawa et al, 2009); identify novel S. aureus virulence genes (Kaito et al, 2005; Miyazaki et al, 2012); and identify novel probiotic bacteria that promote survival during P. aeruginosa infection (Nishida et al, 2016). Additionally, infection model of multiple pathogenic microorganisms Stenotrophomonas maltophilia (Hamamoto et al, 2004); Vibrio vulnificus (Yamamoto et al, 2016); Vibrio cholera (Kaito et al, 2002); Candida tropicalis (Hamamoto et al, 2004); Candida albicans (Hamamoto et al, 2004); Aspergillus fumigatus (Nakamura et al, 2017a); Cryptococcus neoformans (Matsumoto et al, 2012); and laboratory generated vancomycin-resistant S. aureus VR7 (Tabuchi et al, 2017) have been developed and the success of the antimicrobial to rescue the silkworms from the effect of pathogens have been reported (Table 2).…”

Decreased sugar concentration in vegetable and fruit juices by growth of functional lactic acid bacteria

“…We have studied functional lactic acid bacteria with innate immunity-stimulating activity and postprandial hyperglycemia inhibitory activity (1,2). The use of functional lactic acid bacteria for manufacturing fermented food is thought to contribute to maintaining human health.…”

Lactic acid bacteria of the <i>Leuconostoc</i> genus with high innate immunity-stimulating activity

“…We demonstrated by monitoring muscle contraction ability in mouse macrophages that purified polysaccharides from green tea stimulate the production of cytokines (7). Using this system, we also demonstrated that certain species of lactic acid bacteria exhibit relatively high innate immunity-stimulating activity (8). Here we describe that three strains of lactic acid bacteria of the genus Leuconostoc isolated from kimchi and rice bran have high innate immunity-stimulating activity.…”

“…Some plant-origin lactic acid bacteria, such as Lactococcus lactis, however, can grow in milk (8,9). We examined whether the abovementioned lactic acid bacterial strains could grow in milk.…”