Lactic acid in tumor invasion

Niu, Dun; Luo, Ting; Wang, Hanbin; Xia, Yiniu; Xie, Zhizhong

doi:10.1016/j.cca.2021.08.011

Cited by 35 publications

(31 citation statements)

References 107 publications

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“…In conclusion, this evidence indicates that lactate may be a signaling molecule that increases MMP expression, leading to collagen degradation and the increased invasion of tumor cells. EMT is mainly activated by a cascade of specific factors/cytokines and related signaling pathways, and lactate has been shown to be involved in the TGF-β/Smad and Wnt/β-catenin signaling pathways, among others, that can activate EMT 249 .…”

Section: Roles Of Lactic Acid In Pathophysiological Processesmentioning

confidence: 99%

Lactate metabolism in human health and disease

Yang

Zhang

et al. 2022

Sig Transduct Target Ther

441

234

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The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells, organs and tissues. Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao’s research group in 2019. Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation, neural excitation, inflammation and other biological processes. An indispensable substance for various physiological cellular functions, lactate plays a regulatory role in different aspects of energy metabolism and signal transduction. Therefore, a comprehensive review and summary of lactate is presented to clarify the role of lactate in disease and to provide a reference and direction for future research. This review offers a systematic overview of lactate homeostasis and its roles in physiological and pathological processes, as well as a comprehensive overview of the effects of lactylation in various diseases, particularly inflammation and cancer.

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Section: Roles Of Lactic Acid In Pathophysiological Processesmentioning

confidence: 99%

Lactate metabolism in human health and disease

Yang

Zhang

et al. 2022

Sig Transduct Target Ther

441

234

View full text Add to dashboard Cite

show abstract

“…Lactate can inhibit immune cells, such as monocytes, that are responsible for eliminating unhealthy cells, including cancer [ 33 ]. The accumulation of lactate also reorganizes the extracellular matrix, which could promote tumour invasion [ 22 ]. However, this enhanced glycolysis was only observed in the RT4 cells for basal glycolysis, not maximal glycolysis.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, BPA-exposed cancer-associated fibroblasts (CAFs) displayed an increased glycolytic metabolism, leading to extracellular acidification [ 20 ]. This enhanced acidification can lead to the inhibition of immune cells, such as monocytes, as well as reorganization of the extracellular matrix [ 21 , 22 ], thus potentially promoting bladder cancer progression [ 20 ]. The hypothesis of this study was that BPA and BPS would impact the energy metabolism and properties of normal urothelial cells and bladder cancer cells, i.e., migration, proliferation and expression of cell markers of invasive potential, which could promote bladder cancer initiation and progression.…”

Section: Introductionmentioning

confidence: 99%

Bisphenols A and S Alter the Bioenergetics and Behaviours of Normal Urothelial and Bladder Cancer Cells

Pellerin

Chabaud

et al. 2022

Cancers

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Bisphenol A (BPA) and bisphenol S (BPS) are used in the production of plastics. These endocrine disruptors can be released into the environment and food, resulting in the continuous exposure of humans to bisphenols (BPs). The bladder urothelium is chronically exposed to BPA and BPS due to their presence in human urine samples. BPA and BPS exposure has been linked to cancer progression, especially for hormone-dependent cancers. However, the bladder is not recognized as a hormone-dependent tissue. Still, the presence of hormone receptors on the urothelium and their role in bladder cancer initiation and progression suggest that BPs could impact bladder cancer development. The effects of chronic exposure to BPA and BPS for 72 h on the bioenergetics (glycolysis and mitochondrial respiration), proliferation and migration of normal urothelial cells and non-invasive and invasive bladder cancer cells were evaluated. The results demonstrate that chronic exposure to BPs decreased urothelial cells’ energy metabolism and properties while increasing them for bladder cancer cells. These findings suggest that exposure to BPA and BPS could promote bladder cancer development with a potential clinical impact on bladder cancer progression. Further studies using 3D models would help to understand the clinical consequences of this exposure.

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“…Lactate inhibits immune cells, including monocytes involved in cancer cell elimination [38], which could promote cancer initiation and progression through the inhibition of the immune system [35]. Lactate directly leads to the acidification of the extracellular environment, promoting tumor invasion through a reorganization of the matrix [35,39]. Lactate also acts as a chemoattractant molecule and is used as a metabolite for cancer cells [33].…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression

Pellerin

Chabaud

Pouliot

et al. 2021

Cancers

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Bisphenol A (BPA) is an endocrine-disrupting molecule used in plastics. Through its release in food and the environment, BPA can be found in humans and is mostly excreted in urine. The bladder is therefore continuously exposed to this compound. BPA can bind to multiple cell receptors involved in proliferation, migration and invasion pathways, and exposure to BPA is associated with cancer progression. Considering the physiological concentrations of BPA in urine, we tested the effect of nanomolar concentrations of BPA on the metabolism of bladder fibroblasts and cancer-associated fibroblasts (CAFs). Our results show that BPA led to a decreased metabolism in fibroblasts, which could alter the extracellular matrix. Furthermore, CAF induction triggered a metabolic switch, similar to the Warburg effect described in cancer cells. Additionally, we demonstrated that nanomolar concentrations of BPA could exacerbate this metabolic switch observed in CAFs via an increased glycolytic metabolism, leading to greater acidification of the extracellular environment. These findings suggest that chronic exposure to BPA could promote cancer progression through an alteration of the metabolism of stromal cells.

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Lactic acid in tumor invasion

Cited by 35 publications

References 107 publications

Lactate metabolism in human health and disease

Lactate metabolism in human health and disease

Bisphenols A and S Alter the Bioenergetics and Behaviours of Normal Urothelial and Bladder Cancer Cells

Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression

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