Lactiplantibacillus plantarum P9 improved gut microbial metabolites and alleviated inflammatory response in pesticide exposure cohorts

Liu, Wenjun; Li, Changkun; Li, Bohai; Shang, Qingxiang; Han, Zhe; Zhang, Yuan; Liu, Xiufang; Fan, Huiqing; Zhang, Jiachao; Chen, Yongfu; Zhang, Heping

doi:10.1016/j.isci.2022.104472

Cited by 16 publications

(14 citation statements)

References 47 publications

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“…Although host and gut microbiota metabolic activities can occur simultaneously, the host relies on its microbiome to collect enzymes for digestion and metabolism [ 11 , 12 ]. Recent studies have shown that an unbalanced microflora, along with its related metabolites, such as short-chain fatty acids [ 13 ], and other metabolic disorders may be related to various diseases, including metabolic perturbation and inflammatory bowel disease [ 14 , 15 ]. Most studies on gut microbiota and metabolic disorders have focused on short-chain fatty acids.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota Mediates Skin Ulceration Syndrome Outbreak by Readjusting Lipid Metabolism in Apostichopus japonicus

Zhang

Song

et al. 2022

IJMS

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The intestinal tract is the most important location for symbiotes and pathogens, and the microbiota plays a crucial role in affecting the health of the gut and other host organs. Dysbacteriosis in the intestinal system has been proven to be significant in skin ulceration syndrome (SUS) in sea cucumbers. This study investigates whether the gut microbiota and lipid metabolites are relevant to the initiation and progression of SUS in a Vibrio-splendidus-infected sea cucumber model. The tight junction genes were downregulated and the inflammatory factor gene transcriptions were upregulated after V. splendidus infection in the intestinal tissue of the sea cucumber. V. splendidus infection modulated the gut microbiota by interacting with Psychromonas macrocephali, Propionigenium maris, Bacillus cereus, Lutibacter flavus, and Hoeflea halophila. Meanwhile, the metabolites of the long-chain fatty acids in the intestinal tissue, including triglycerides (TG), phosphatidylethanolamines (PE), and phosphatidylglycerols (PG), were altered after V. splendidus infection. V. splendidus engaged in positive interactions with PG and PE and negative interactions with specific TG. These results related to gut microbiota and metabolites can offer practical assistance in the identification of the inflammatory mechanisms related to SUS, and this study may serve as a reference for predicting the disease.

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Section: Introductionmentioning

confidence: 99%

Gut Microbiota Mediates Skin Ulceration Syndrome Outbreak by Readjusting Lipid Metabolism in Apostichopus japonicus

Zhang

Song

et al. 2022

IJMS

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“…It has been suggested that CPF, by stimulating the production of pro‐inflammatory cytokines, leads to liver and kidney tissue damage in rats 17,18 . Additionally, dysfunction of the intestinal microbiota has been reported due to the inflammatory responses to pesticides 19 . Regarding the maximum residue limits (MRLs) of CPF, many studies have shown higher levels in some foods 20,21 .…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have revealed the capacity of LAB to reduce the amount of CPF in fermented foods such as pickled Chinese cabbage, 28 Sauerkraut 29 and fermented milk, 30 which can be a suggestion to reduce the toxicity of residual CPF in the body. Furthermore, the potential of probiotics in reducing oxidative stress and the accumulation of free radicals, 31 relieving inflammatory responses 32 and improving the function of the immune system 19 can make them a suitable option for reducing the adverse effects of CPF in body tissues.…”

Section: Introductionmentioning

confidence: 99%

Probiotic bacteria alleviate chlorpyrifos‐induced rat testicular and renal toxicity: A possible mechanism based on antioxidant and anti‐inflammatory activity

Nejati,

Nematollahi,

Doraghi

et al. 2023

Basic Clin Pharma Tox

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Chlorpyrifos (CPF) has caused many potential toxicities in nontarget organisms. Fewer studies have been conducted on the effects of lactic acid bacteria (LAB) in mitigating tissue damage induced by CPF in vivo. Therefore, we investigated CPF renal and testicular toxicity and the alleviate effect of probiotic lactobacilli, based on antioxidant and anti‐inflammatory activity, on induced toxicity in an animal model. Biochemical assays showed that CPF induced oxidative stress along with a change in superoxide dismutase (SOD) and catalase (CAT) activity in a tissue dependent manner. After treatment with CPF, testicular and renal levels of TNF‐α were significantly reduced and enhanced, respectively, compared to the control group. Probiotic treatment restored renal and testicular TNF‐α levels and modulated and blocked the increasing effect of CPF on renal IL‐1β levels. Testicular IL‐1β levels in the probiotic‐treated and CPF groups demonstrated similar values. Exposure to CPF significantly induced renal histopathological damage that, of course, was completely inhibited by treatment with Lactobacillus casei and the LAB mixture. In summary, CPF showed significant toxicological effects on oxidative stress and the inflammation rate in CPF‐exposed rats. Therefore, supplementation with probiotic bacteria may alleviate CPF renal toxicity and mitigate its oxidative stress and inflammation effects.

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“…Supplementation with fructooligosaccharides attenuates metabolic disturbances in mice induced by co-exposure to chlorfenapyr and acetamiprid . In addition, consumption of Lactiplantibacillus plantarum P9 could improve the gut microbiota and its metabolic profile and reduce the body’s inflammatory response caused by pesticides . Meanwhile, a healthy dietary pattern, including the Mediterranean diet or a vegetarian diet, also could maintain the homeostasis of gut microbiota, thereby alleviating insulin resistance and obesity caused by chlorpyrifos .…”

mentioning

confidence: 99%

“…6 In addition, consumption of Lactiplantibacillus plantarum P9 could improve the gut microbiota and its metabolic profile and reduce the body's inflammatory response caused by pesticides. 7 Meanwhile, a healthy dietary pattern, including the Mediterranean diet or a vegetarian diet, also could maintain the homeostasis of gut microbiota, thereby alleviating insulin resistance and obesity caused by chlorpyrifos. 8 In fact, many probiotics and prebiotics have been shown to modulate the gut microbiota.…”

mentioning

confidence: 99%

Interaction between Gut Microbiota and Health Hazards of Pesticides: Water Can Carry a Boat, but It Can Also Capsize It

Gu,

Yan,

Zhu

et al. 2023

ACS Food Sci. Technol.

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Lactiplantibacillus plantarum P9 improved gut microbial metabolites and alleviated inflammatory response in pesticide exposure cohorts

Cited by 16 publications

References 47 publications

Gut Microbiota Mediates Skin Ulceration Syndrome Outbreak by Readjusting Lipid Metabolism in Apostichopus japonicus

Gut Microbiota Mediates Skin Ulceration Syndrome Outbreak by Readjusting Lipid Metabolism in Apostichopus japonicus

Probiotic bacteria alleviate chlorpyrifos‐induced rat testicular and renal toxicity: A possible mechanism based on antioxidant and anti‐inflammatory activity

Interaction between Gut Microbiota and Health Hazards of Pesticides: Water Can Carry a Boat, but It Can Also Capsize It

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