Lactobacillus fermentum attenuates the proinflammatory effect of Yersinia enterocolitica on human epithelial cells

Abstract

Our results lead to the conclusion that L. fermentum inhibits the Y. enterocolitica-induced IL-8 production by a possibly secreted phospholipid of <10 kDa molecular weight. These data suggest that L. fermentum may have probiotic properties modulating intestinal inflammatory responses and might offer new therapeutic strategies in the treatment of intestinal inflammatory diseases.

Cyclopropane fatty acid synthase mutants of probiotic human-derivedLactobacillus reuteriare defective in TNF inhibition

“…However, the wall, DNA and exopolysaccharides as possible immunomodulatory factors. [7][8][9][10] Immunoprobiotics are potential therapies for various immune-mediated disorders such as Crohn disease. 11 The inflammatory cytokine TNF, produced by monocytes and macrophages, is a key mediator of intestinal inflammation.…”

Immunomodulatory effects of Lactobacillus plantarum on human colon cancer cells

“…Each probiotic species may have an individual mechanism of action. In particular, Lactobacillus plantarum attenuates intestinal inflammation [37], modulates chronic inflammation [38] and induces the expression of soluble factors in Caco-2 and THP-1 cells [39,40]. Thus, in this study we analyzed the induction of the messenger RNA (mRNA) and protein expressions of IL-23 and HBD-2, HBD-3 in Caco-2 cells exposed to L. plantarum (DSMZ 12028), isolated from Portuguese chouriço [41] compared to Caco-2 cells stimulated with lipopolysaccharide from S. enterica serovar typhimurium.…”

Lactobacillus paracasei and Lactobacillus plantarum strains downregulate proinflammatory genes in an ex vivo system of cultured human colonic mucosa

“…Some probiotic strains maintain or restore the epithelial barrier function after pathogen challenge (Otte and Podolsky 2004) or proinflammatory cytokine stimulus (Resta-Lenert and Barrett 2006), and others alter the capacity of intestinal epithelial cells (IEC) to release proinflammatory mediators or directly modify immune cell activity. Studies using IEC cultures have shown the downregulation of the secretion of the proinflammatory chemokine IL-8 (Frick et al 2007; Kamada et al 2008;Ma et al 2004;O'Hara et al 2006) and other NF-jB regulated chemokines, such as MCP-1 (Petrof et al 2009) or CCL-20 (Sibartie et al 2009), as well as a mechanism for the inhibition of IP-10 secretion. Also, a number of works demonstrated that probiotic bacteria directly interacting with immune cells elicit a differential cytokine production, thereby driving the polarization of T cells toward T h 1, T h 2, T h 17 or regulatory T cells (Foligne et al 2007a, b;Kekkonen et al 2008;Latvala et al 2008).…”