Lactobacillus fermentum MCC2760 abrogate high-fat induced perturbations in the enterohepatic circulation of bile acids in rats

Nair, Devika; Zarei, Mahsa; Halami, Prakash M.; Talahalli, Ramaprasad Ravichandra

doi:10.1016/j.lfs.2023.121563

Cited by 3 publications

References 47 publications

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Lactobacillus fermentum MCC2760 Attenuates Heated Oil‐Induced Brain Oxidative Stress and Inflammation via Modulation of NRF2 and NF‐kB in Rats

Keremane,

Yashwanthkumar,

Uppin

et al. 2024

Molecular Nutrition Food Res

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ScopeReusing deep‐fried oil is a common practice to cut costs, and their consumption may affect brain function. Hence, the study investigates the modulatory potential of Lactobacillus fermentum MCC2760 (LF) on heated oil‐induced brain oxidative stress (OS) and inflammation that may have a bearing on cognition in experimental rats.Methods and resultsFemale Wistar rats are fed with diets containing native sunflower oil (N‐SFO), native canola oil (N‐CNO), heated sunflower oil (H‐SFO), heated canola oil (H‐CNO), heated sunflower oil with probiotic (H‐SFO + LF), or heated canola oil with probiotic (H‐CNO + LF} for 60 days. Compared to respective controls, heated oils significantly (p < 0.05) increased OS by decreasing antioxidant defense enzymes and nuclear factor erythroid 2‐related factor 2 (NRF2) activity. Further, heated oil elevates brain expression of cytosolic phospholipase A2 (cPLA2), cyclooxygenase‐2 (COX‐2), prostaglandin‐E receptor 4 (EP‐4), intercellular adhesion molecule 1 (ICAM‐1), nitric oxide synthase 2 (NOS‐2), followed by an increased production of proinflammatory eicosanoids (prostaglandin E2 [PGE2] and leukotriene B4 [LTB4]) and cytokines (tumor necrosis factor‐α [TNF‐α], monocyte chemoattractant protein‐1 [MCP‐1], interleukin‐1β [IL‐1β], and interleukin‐6 [IL‐6]). The increased nuclear translocation of nuclear factor kappa beta (NF‐kB) in heated oil‐fed groups’ brains corroborates the heightened inflammatory response. Heated oils decrease neurotrophins and neuron development markers. However, administration of LF abrogates the heated oil‐induced alterations significantly (p < 0.05).ConclusionsThe present study is novel in demonstrating the protective role of probiotic LF against heated‐oil‐induced brain OS and inflammation in rats.

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Lactobacillus fermentum MCC2760 Attenuates Heated Oil‐Induced Brain Oxidative Stress and Inflammation via Modulation of NRF2 and NF‐kB in Rats

Keremane,

Yashwanthkumar,

Uppin

et al. 2024

Molecular Nutrition Food Res

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Gut microbiota and metabolites as predictors of biologics response in inflammatory bowel disease: A comprehensive systematic review

Wang,

Gu,

Chu

et al. 2024

Microbiological Research

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Synergistic effects of pro-biotics or post-biotics with n-3 highly unsaturated fatty acids on chronic mild stress-induced dyslipidemia in rats

Lee,

Jin,

Park

2024

Preprint

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This research is objective to examine the synergistic effects of pro- or post-biotics combined with n-3 highly unsaturated fatty acids (HUFA) on dyslipidemia caused by depression through modulating biosynthesis and clearance of cholesterol. Rats were assigned into 7 random groups, each containing 8 rats: n-3 HUFA deficient diet without chronic mild stress (CMS), CMS with n-3 HUFA deficient diet, pro-biotics, post-biotics, n-3 HUFA, pro-biotics and n-3 HUFA, and post-biotics and n-3 HUFA. The induction of CMS occurred over five weeks during the 12-week dietary supplementation period. The pro-biotics, post-biotics, and n-3 HUFA ameliorated dyslipidemia caused by CMS and downregulated cholesterol biosynthesis through decreasing sterol regulatory element-binding protein-2 (Biotics, P < 0.001; n3, P < 0.001; synergistic, P = 0.014) and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (Biotics, P < 0.001; n3, P < 0.001; synergistic, P < 0.001). Moreover, they upregulated cholesterol clearance by increasing low-density lipoprotein-cholesterol reuptake through proprotein convertase subtilisin/kexin type 9 (Biotics, P < 0.001; n3, P < 0.001; synergistic, P = 0.036) and bile acids biosynthesis through cytochrome p450 family 7 subfamily A member 1 (Biotics, P < 0.001; n3, P < 0.001; synergistic, P < 0.001) and cytochrome p450 family 27 subfamily A member 1 (Biotics, P < 0.001; n3, P < 0.001; synergistic, P = 0.001). Therefore, pro-biotics or post-biotics with n-3 HUFA exert synergistic hypocholesterolemic effects on dyslipidemia induced by CMS through regulating biosynthesis and cholesterol clearance.

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Lactobacillus fermentum MCC2760 abrogate high-fat induced perturbations in the enterohepatic circulation of bile acids in rats

Cited by 3 publications

References 47 publications

Lactobacillus fermentum MCC2760 Attenuates Heated Oil‐Induced Brain Oxidative Stress and Inflammation via Modulation of NRF2 and NF‐kB in Rats

Lactobacillus fermentum MCC2760 Attenuates Heated Oil‐Induced Brain Oxidative Stress and Inflammation via Modulation of NRF2 and NF‐kB in Rats

Gut microbiota and metabolites as predictors of biologics response in inflammatory bowel disease: A comprehensive systematic review

Synergistic effects of pro-biotics or post-biotics with n-3 highly unsaturated fatty acids on chronic mild stress-induced dyslipidemia in rats

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