Lactobacillus GG effect in increasing IFN-γ production in infants with cow's milk allergy

Pohjavuori, Emma; Viljanen, Mirva; Korpela, Riitta; Kuitunen, Mikael; Tiittanen, Minna; Vaarala, Outi; Savilahti, Erkki

doi:10.1016/j.jaci.2004.03.036

Cited by 301 publications

(246 citation statements)

References 25 publications

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“…Further beneficial results with P. freudenreichii JS were obtained with different randomised, placebo-controlled, double-blind trials in humans such as: reduction in the serum level of Creactive protein (an inflammation marker) [172]; induction of IL-4 and IFN-gamma production in PBMCs of infants with cow's milk allergy [173]; prevention of IgE-associated allergy in caesarean-delivered children [174] and increase in the resistance to respiratory infections during the first two years of life [175].…”

Section: Dairy Propionibacteria: Less Conventional Probiotics To Imprmentioning

confidence: 99%

Dairy Propionibacteria: Less Conventional Probiotics to Improve the Human and Animal Health

Zárate¹

2012

Probiotic in Animals

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Section: Dairy Propionibacteria: Less Conventional Probiotics To Imprmentioning

confidence: 99%

Dairy Propionibacteria: Less Conventional Probiotics to Improve the Human and Animal Health

Zárate¹

2012

Probiotic in Animals

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“…134,135 In contrast, improvements in SCORAD scores were associated with increased IFN-γ production in studies where probiotic supplementation was beneficial at least in certain subgroups of patients. 136,137 In addition, the induction of low-grade infl ammation, as indicated by increased serum CRP and IL-6 levels, has been proposed as a mechanism. 130 Note, however, that in the above study, serum cytokine concentrations were below the detection limit in the majority of samples, including in almost 80% of the IL-6 samples.…”

Section: Probiotics In Allergic Diseasesmentioning

confidence: 99%

“…In the other studies, suffi cient blood samples were available only from subsets of study participants and no information was provided on how representative these children were of the whole study population. 136,137 In addition, in one of these investigations signifi cant differences in baseline IFN-γ production between the probiotic and placebo groups were not taken into account, raising the question of whether the observed effects were really attributable to probiotic supplementation, particularly given that allergen-specifi c IFN-γ responses were not signifi cantly altered. 137 Probiotics in animal models of sensitization and allergic manifestations Because of these methodological shortcomings, the available data from clinical trials provides little insight into the mechanisms accounting for the strain-specifi c benefi ts of probiotic supplementation.…”

Section: Probiotics In Allergic Diseasesmentioning

confidence: 99%

Probiotics and immunity

et al. 2009

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Probiotics are defi ned as live microorganisms that, when administered in adequate amounts, confer a health benefi t on the host, including the gastrointestinal tract. While this benefi cial effect was originally thought to stem from improvements in the intestinal microbial balance, there is now substantial evidence that probiotics can also provide benefi ts by modulating immune functions. In animal models, probiotic supplementation is able to provide protection from spontaneous and chemically induced colitis by downregulating infl ammatory cytokines or inducing regulatory mechanisms in a strain-specifi c manner. In animal models of allergen sensitization and murine models of asthma and allergic rhinitis, orally administered probiotics can straindependently decrease allergen-specifi c IgE production, in part by modulating systemic cytokine production. Certain probiotics have been shown to decrease airway hyperresponsiveness and infl ammation by inducing regulatory mechanisms. Promising results have been obtained with probiotics in the treatment of human infl ammatory diseases of the intestine and in the prevention and treatment of atopic eczema in neonates and infants. However, the fi ndings are too variable to allow fi rm conclusions as to the effectiveness of specifi c probiotics in these conditions.

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“…Intervention with B. bifidum, L. acidophilus, L. casei and L. salivarius effectively reduced signs of atopic dermatitis and serum cytokines interleukin (IL-5, IL-6, IFN-γ and serum IgE) [68]. L. rhamnosus GG could up-regulate IFN-γ and IL-10 in infants with cow's milk allergy or with IgE-associated dermatitis [69]. The use of Lactobacillus delbruekii and Lactobacillus fermentum significantly reduced IL-6 concentration and expression of TNF-α and NFκB in colon of patients with ulcerative colitis [70].…”

Section: Probiotic Effect On Immune Responsesmentioning

confidence: 94%

Probiotics and Periodontal Diseases

Morales¹,

Bravo²,

Bedoya³

et al. 2017

Insights Into Various Aspects of Oral Health

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Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. Probiotics have been used to directly modify the resident oral microbiome and proposed to modulate immune responses. In dentistry, probiotics have been employed as useful adjuncts for the reduction of caries development, suppressing oral Candida infection and controlling halitosis. Plaque-induced gingivitis is a gingival inflammation caused by the adherent bacterial biofilm around teeth. Gingivitis and periodontitis are considered to be a continuum of the same inflammatory process, although many gingivitis lesions do not progress to periodontitis. Periodontitis is an inflammatory process that affects the attachment structures of teeth. It constitutes a second cause of tooth loss worldwide. Conventional treatment modalities of periodontal disease include non-surgical and/or surgical management, with an emphasis on mechanical debridement. However, mechanical debridement as a sole therapy is not always effective to improve clinical parameters. A growing number of studies support probiotic therapy to prevent or treat gingivitis and periodontitis. Oral administration of probiotics is an effective adjunct in reducing pathogenic bacteria and improving clinical signs of disease. Probiotics may serve as adjunct or replacement therapy substitute antibiotics in managing human periodontal infections in future.

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Lactobacillus GG effect in increasing IFN-γ production in infants with cow's milk allergy

Cited by 301 publications

References 25 publications

Dairy Propionibacteria: Less Conventional Probiotics to Improve the Human and Animal Health

Dairy Propionibacteria: Less Conventional Probiotics to Improve the Human and Animal Health

Probiotics and immunity

Probiotics and Periodontal Diseases

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