Lactobacillus helveticus suppresses experimental rheumatoid arthritis by reducing inflammatory T cell responses

Kim, Jung-Eun; Chae, Chang Suk; Kim, Gi-Cheon; Hwang, Wooncheol; Hwang, Ji-Sun; Hwang, Sun-Mi; Kim, Young; Ahn, Young-Tae; Park, Sung‐Gyoo; Jun, Chang‐Duk; Rudra, Dipayan; Im, Sungbin

doi:10.1016/j.jff.2015.01.002

Cited by 38 publications

(23 citation statements)

References 56 publications

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“…It is believed that L. heleveticus improved disease activity by reducing pro-inflammatory cytokines TNF-α, IFN-γ, and IL-17A and enhancing IL-10 expression by CD4 T cells. 23 These findings are consistent with the So et al 21 study. Their findings demonstrate the ability of probiotics to treat experimental RA, which may translate to beneficial effects in humans.…”

Section: Lactobacillus Helveticussupporting

confidence: 91%

“…The study found that supplementation of probiotics three weeks prior to induction of CIA had a preventative effect on the development of CIA. 23 First, the researchers tested three strains as pretreatment options: Bifidobacterium longum (B. longum), L. helveticus, and Lactobacillus johnsonii (L. johnsonii). The mice were given a dose of 5 × 10 8 CFU/day.…”

Section: Lactobacillus Helveticusmentioning

confidence: 99%

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Probiotics for the Management of Rheumatoid Arthritis

Dhanoa

2019

Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases

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The human body contains millions of diverse microorganisms that collectively make up the human microbiome. There are variations in the density of bacteria across body sites, and the composition of these microbial species is regulated by several factors including genetics, diet, infectious agents, and other environmental triggers. Pioneering research in this field hypothesized that host-microbe equilibrium is essential for the health of the host and that changes or dysbiosis within the equilibrium are associated with the pathogenesis of several diseases. Recent studies have utilized new sequencing technologies to draw an association between dysbiosis and inflammatory disease. Rheumatoid arthritis (RA) is an inflammatory autoimmune disease in which synovial inflammation causes joint failure. Probiotics have the potential to stabilize the host-microbe equilibrium and decrease the inflammatory process. The available randomized clinical trials (RCTs) show that probiotics can reduce proinflammatory cytokines; however, the clinical effects of probiotics on RA disease activity remain unsettled.

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Section: Lactobacillus Helveticussupporting

confidence: 91%

Section: Lactobacillus Helveticusmentioning

confidence: 99%

Probiotics for the Management of Rheumatoid Arthritis

Dhanoa

2019

Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases

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“…Our results on T cell cytokines and IgE clearly demonstrated that L. murinus polarized the Th1/Th2 immunobalance towards Th1 direction in allergic mice. Probiotic LAB has been reported to induce immunomodulatory effects via various mechanisms depending on different probiotic LAB studied (Chiu, Tsai, Lin, Chotirosvakin, & Lin, 2014;Faghfoori, Gargari, Gharamaleki, Bagherpour, & Khosroushahi, 2015;Herrera, Salva, Villena, Barbieri, & Alvarez, 2013;Juarez, Villena, Salva, de Valdez, & Rodriguez, 2013;Kim et al, 2015;Mian et al, 2016). In this study, the duodenal expression of IL-10 was attenuated in allergic mice treated with L. murinus.…”

Section: Discussionmentioning

confidence: 64%

The probiotic activity of Lactobacillus murinus against food allergy

Huang

Shen

Liang

et al. 2016

Journal of Functional Foods

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“…Previous reports have demonstrated the effects of LAB treatment in murine models of RA (Kato et al, 1998; Kano et al, 2003; Amdekar et al, 2011; Kim et al, 2015). The Lactobacillus casei strain Shirota reduced the development of CIA and the level of CII-specific antibodies in the serum (Kato et al, 1998).…”

Section: Discussionmentioning

confidence: 98%

Preventive Effect of Lactobacillus helveticus SBT2171 on Collagen-Induced Arthritis in Mice

et al. 2017

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We recently reported that the intraperitoneal inoculation of Lactobacillus helveticus SBT2171 inhibited the development of collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis (RA). In the present study, we evaluated the effect of the oral administration of L. helveticus SBT2171 on CIA development and on the regulation of antigen-specific antibody production and inflammatory immune cells, which have been implicated in the development of RA. Both oral administration and intraperitoneal inoculation of L. helveticus SBT2171 reduced joint swelling, body weight loss, and the serum level of bovine type II collagen (CII)-specific antibodies in the CIA mouse model. The intraperitoneal inoculation also decreased the arthritis incidence, joint damage, and serum level of interleukin (IL)-6. In addition, the numbers of total immune cells, total B cells, germinal center B cells, and CD4+ T cells in the draining lymph nodes were decreased following intraperitoneal inoculation of L. helveticus SBT2171. These findings demonstrate the ability of L. helveticus SBT2171 to downregulate the abundance of immune cells and the subsequent production of CII-specific antibodies and IL-6, thereby suppressing the CIA symptoms, indicating its potential for use in the prevention of RA.

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Lactobacillus helveticus suppresses experimental rheumatoid arthritis by reducing inflammatory T cell responses

Cited by 38 publications

References 56 publications

Probiotics for the Management of Rheumatoid Arthritis

Probiotics for the Management of Rheumatoid Arthritis

The probiotic activity of Lactobacillus murinus against food allergy

Preventive Effect of Lactobacillus helveticus SBT2171 on Collagen-Induced Arthritis in Mice

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