Lactobacillus paraplantarum THG-G10 as a potential anti-acne agent with anti-bacterial and anti-inflammatory activities

Min, Hye Jung; Kim, Su Kyung; Kook, Moo Chang; Yi, Tae–Hoo

doi:10.1016/j.anaerobe.2020.102243

Cited by 14 publications

(14 citation statements)

References 25 publications

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“…Lactobacillus, a well-characterized genus in LAB, is beneficial for skin health improvement [7,8]. Specifically, various strains of L. plantarum have been reported to improve acne vulgaris with broad anti-inflammatory and anti-pathogenic bacterial activities as well as with modulation of bacterial flora in the skin [12,14,23]. Topically applied L. plantarum on the face of patients with mild acne vulgaris reduces acne lesion size and erythema [12].…”

Section: Discussionmentioning

confidence: 99%

“…Topically applied L. plantarum on the face of patients with mild acne vulgaris reduces acne lesion size and erythema [12]. Treatment with L. plantarum THG-10 in vitro decreases the growth of C. acnes and nitric oxide production, which is induced by the inflammation process [23]. Furthermore, results from topically applied studies in female subjects indicate that L. plantarum-GMNL6 reduces erythema and the proportion of Propionibacterium genus in the face [14].…”

Section: Discussionmentioning

confidence: 99%

“…In fact, L. rhamnosus SP1 supplement decreases clinical severity and IGF-1 mRNA expression in the skin of acne patients [38]. However, the beneficial effects of various strains of L. plantarum on decreased acne severity and sebum production have been reported mostly from topically applied and in vitro studies [12,14,23], and little information is available on the relationship between ingested L. plantarum and altered levels of insulin, IFG-1 and BCAA in either the serum or skin of acne patients. Alternatively, L. plantarum CJLP55 has been reported to have immunomodulation effects with altered cytokine production [10,11].…”

Section: Discussionmentioning

confidence: 99%

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Effects of Lactobacillus plantarum CJLP55 on Clinical Improvement, Skin Condition and Urine Bacterial Extracellular Vesicles in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Study

Kim

Choi

et al. 2021

Nutrients

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Lactobacillus plantarum CJLP55 has anti-pathogenic bacterial and anti-inflammatory activities in vitro. We investigated the dietary effect of CJLP55 supplement in patients with acne vulgaris, a prevalent inflammatory skin condition. Subjects ingested CJLP55 or placebo (n = 14 per group) supplements for 12 weeks in this double-blind, placebo-controlled randomized study. Acne lesion count and grade, skin sebum, hydration, pH and surface lipids were assessed. Metagenomic DNA analysis was performed on urine extracellular vesicles (EV), which indirectly reflect systemic bacterial flora. Compared to the placebo supplement, CJLP55 supplement improved acne lesion count and grade, decreased sebum triglycerides (TG), and increased hydration and ceramide 2, the major ceramide species that maintains the epidermal lipid barrier for hydration. In addition, CJLP55 supplement decreased the prevalence of Proteobacteria and increased Firmicutes, which were correlated with decreased TG, the major skin surface lipid of sebum origin. CJLP55 supplement further decreased the Bacteroidetes:Firmicutes ratio, a relevant marker of bacterial dysbiosis. No differences in skin pH, other skin surface lipids or urine bacterial EV phylum were noted between CJLP55 and placebo supplements. Dietary Lactobacillus plantarum CJLP55 was beneficial to clinical state, skin sebum, and hydration and urine bacterial EV phylum flora in patients with acne vulgaris.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of Lactobacillus plantarum CJLP55 on Clinical Improvement, Skin Condition and Urine Bacterial Extracellular Vesicles in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Study

Kim

Choi

et al. 2021

Nutrients

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“…Lactobacillus has positive effects on acne by improving skin appearance [31], decreasing sebum secretion [32], and reducing comedones count [33]. The positive effects of probiotics have been mainly attributed to the inhibitory activities towards skin pathogens (e.g., Staphylococcus aureus), and commensal bacteria (e.g., C. acnes) [34][35][36].…”

Section: Disclosuresmentioning

confidence: 99%

Evaluation of A Novel Topical Formulation for The Treatment of Problematic Skin: Results of An Italian Clinical Study

Alice¹,

Rima²,

Michela³

et al. 2022

J Dermatol Res Ther

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Introduction:Problematic skin conditions such as atopic dermatitis, acne vulgaris, and psoriasis are directly linked to microbial imbalance or 'dysbiosis'. Alterations of skin microbial communities along with other contributing factors, cause skin barrier dysfunction triggering immune and inflammatory responses. Acne is a prevalent problematic skin disorder characterized by unpleasant inflammatory lesions (e.g., pustules, papules), scars, and erythema which often cause psychological distress in acne patients. Common medications aim to reduce and control acne symptoms. However, most of these agents are associated with side effects and high cost. Therefore, alternative treatments are needed. Methods:The aim of this pilot-study was to investigate the efficacy and safety of a novel product containing probiotics and hyaluronic acid, "Infinite Skin Microbiome Serum", for the treatment of subjects with acne-prone skin or mild to moderate acne. The study involved twenty-nine healthy volunteers with such characteristics. Enrolled subjects were asked to apply "Infinite Skin Microbiome Serum" nightly for 28 days. Clinical assessments to evaluate number of papules or pustules, extension of the facial area involved by acne, erythema and skin dryness were performed by a dermatologist. Skin hydration was measured with the MoistureMeterSC. Safety and patient's satisfaction were assessed by self-perception questionnaires. Results: Topical application of "Infinite Skin MicrobiomeSerum" reduced the typical manifestations of acne while improving skin hydration after 14 and 28 days of treatment. The product was well tolerated as no side effect was reported. According to the self-perception questionnaires outcome, patients were satisfied with the treatment.Conclusions: Topical application of "Infinite Skin Microbiome Serum" for 28 days resulted in reduced acne manifestations and improved skin hydration. The product was well tolerated as no adverse effects were reported up to 30 days from the end of treatment. Study participants expressed a favorable perception of the treatment effect.

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“…Antibiotics have long been also used to treat acne, such as tetracycline, minocycline, and azithromycin (Farrah & Tan, 2016). Cha et al (2020) studied the MIC of some antibiotics and compounds commonly used to treat C. acnes, the results demonstrated that the minimum concentration of erythromycin and salicylic acid to inhibit the C. acnes growth was both about 1.25 mg/mL, which was equivalent to MBC values of duck egg lysozyme (1.11 mg/mL) and ampicillin concluded from the present study. In addition, many studies have also shown that long-term use of these antibiotics often cause side effects such as mood disturbances, dry skin, dermatitis, burning (Eichenfield, 2015).…”

Section: Mic and Mbc Values Of Duck Egg-white Lysozyme For C Acnesmentioning

confidence: 99%

Investigation of the antibacterial activity against Cutibacterium acnes of lysozyme pu-rified from “Co Co” duck egg whites

Tran¹

2021

CTUJS

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Lysozyme has been applied in various fields such as food technology, medicine, and diagnostics because it can resist many types of bacteria. In this research, lysozyme from duck egg whites was studied to evaluate the antibacterial activity against Cutibacterium acnes (C. acnes) often causing acne on human skin. Lysozyme was purified from duck egg whites by ion-exchange chromatography and gel-filtration chromatography. After that, this enzyme was used to investigate the resistance to C. acnes at different pH, temperature, concentration, and storage conditions. The results presented that lysozyme exhibited the best resistance to C. acnes at pH 6.0 and 6.5 on trypticase - yeast extract - heart extract - glycerol agar (TYEG) medium, at 30°C and 35°C. Additionally, these conditions had the least effect on lysozyme antibacterial activity. The minimal inhibitory concentration (MIC80) and minimum bactericidal concentration (MBC) of lysozyme to C. acnes were 0.55 mg/mL and 1.11 mg/mL, respectively. Lysozyme could keep up the best antimicrobial activity when stored at -20oC and -10oC; After 30 days, it still kept nearly 80% of its activity. These findings will offer a basis for larger-scale production of lysozyme powder for further research and commercial purposes, especially skin-care products.

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Lactobacillus paraplantarum THG-G10 as a potential anti-acne agent with anti-bacterial and anti-inflammatory activities

Cited by 14 publications

References 25 publications

Effects of Lactobacillus plantarum CJLP55 on Clinical Improvement, Skin Condition and Urine Bacterial Extracellular Vesicles in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Study

Effects of Lactobacillus plantarum CJLP55 on Clinical Improvement, Skin Condition and Urine Bacterial Extracellular Vesicles in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Study

Evaluation of A Novel Topical Formulation for The Treatment of Problematic Skin: Results of An Italian Clinical Study

Investigation of the antibacterial activity against Cutibacterium acnes of lysozyme pu-rified from “Co Co” duck egg whites

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