Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation

Hofeld, Benjamin C.; Puppala, Venkata K.; Tyagi, Sudhi; Ahn, Kwang Woo; Anger, Amberly; Song, Jia; Salzman, Nita H.; Hessner, Martin J.; Widlansky, Michael E.

doi:10.1038/s41598-021-83252-7

Cited by 19 publications

(17 citation statements)

References 54 publications

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“…There were 4 and 15 patients in the DAU and non-DAU groups, respectively. A total of 38 samples were obtained from 19 patients before and after oral Lp299v supplementation (Hofeld et al 2021).…”

Section: Microarray Datasetsmentioning

confidence: 99%

“…Subsequent studies con rmed that Lp299v possessed a systemic anti-in ammatory effect and reduced the activity of circulatory in ammatory markers, and it was found that the levels of Janus kinase 2 (JAK2), Guanylate-binding protein 1 (GBP1), and TNF superfamily member 10 (TNFSF10) were reduced in blood after oral Lp299v supplementation. ( Hofeld et al 2021) Hence, the present study aimed to identify differentially expressed genes (DEGs) and the core genes, so as to explore the molecular mechanism. In this study, microarray datasets from the Gene Expression Omnibus (GEO) database were downloaded and analyzed to obtain DEGs, and serum levels were measured before and after oral Lp299v in daily alcohol user (DAU) and non-DAU patients with stable CAD (Hofeld et al 2021).…”

Section: Introductionmentioning

confidence: 99%

“…( Hofeld et al 2021) Hence, the present study aimed to identify differentially expressed genes (DEGs) and the core genes, so as to explore the molecular mechanism. In this study, microarray datasets from the Gene Expression Omnibus (GEO) database were downloaded and analyzed to obtain DEGs, and serum levels were measured before and after oral Lp299v in daily alcohol user (DAU) and non-DAU patients with stable CAD (Hofeld et al 2021). Subsequently, the Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses and construction of a protein-protein interaction (PPI) network were performed to investigate the molecular mechanisms of Lp299v supplementation in patients with stable CAD.…”

Section: Introductionmentioning

confidence: 99%

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Microarray Analysis Reveals the Potential Molecular Mechanism of Lp299v in Stable Coronary Atherosclerotic Disease

Song

Strömberg

et al. 2022

Preprint

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A growing body of evidence has confirmed that inflammatory mechanisms are involved in the formation and treatment of coronary atherosclerotic disease (CAD). An increase in circulatory levels of inflammatory cytokines has been found in patients with CAD, while the molecular mechanisms of inflammation still remain elusive. This study was designed to identify differentially expressed genes (DEGs), and to explore the molecular mechanism and core genes that are involved in the effects of Lactobacillus plantarum 299v (Lp299v) supplementation. Microarray dataset (GSE156357) was downloaded from the Gene Expression Omnibus (GEO) database. The DEGs were identified by the R software. Then, the Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses and construction of protein-protein interaction (PPI) network were performed by DAVID, STRING, and Cytoscape. In daily alcohol user (DAU) group, 7,541 DEGs were identified, including 206 up-regulated and 7,335 down-regulated DEGs. In non-daily alcohol user (non-DAU) group, 2,799 DEGs were identified (2,491 up-regulated and 308 down-regulated DEGs). The GO enrichment analysis revealed that DEGs were mainly enriched in cell division, mitosis, and chemotactic cytokines. The KEGG enrichment analysis showed that Lp299v supplementation reduced the levels of chemotactic cytokines, and weakened immune response. Proteins of G protein-coupled receptor, inflammatory response, regulation of cell proliferation and apoptosis-related proteins were found in the PPI network. The core genes were associated with G protein-coupled receptor, inflammatory response, and cell proliferation and apoptosis. The weighted gene co-expression network analysis (WGCNA) enriched the DEGs in 4 modules. This study indicated the expressions of chemokine receptors and regulation of immune response in the Lp299v supplementation. Meanwhile, it was supposed that chemokine receptors may have a cellular effect.

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Section: Microarray Datasetsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Microarray Analysis Reveals the Potential Molecular Mechanism of Lp299v in Stable Coronary Atherosclerotic Disease

Song

Strömberg

et al. 2022

Preprint

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“… Suppress inflammatory response. Regulated blood pressure [ 134 ] L. johnsonni 3121 L. rhamnosus 86 Mice 30 males 1 × 10 10 CFU/daily for 84 days Improved lipid metabolism. Suppressed of produce adipocyte.…”

Section: Table A1mentioning

confidence: 99%

Probiotic Supplements: Their Strategies in the Therapeutic and Prophylactic of Human Life-Threatening Diseases

Youssef

Ahmed

Zongo

et al. 2021

IJMS

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Chronic diseases and viral infections have threatened human life over the ages and constitute the main reason for increasing death globally. The rising burden of these diseases extends to negatively affecting the economy and trading globally, as well as daily life, which requires inexpensive, novel, and safe therapeutics. Therefore, scientists have paid close attention to probiotics as safe remedies to combat these morbidities owing to their health benefits and biotherapeutic effects. Probiotics have been broadly adopted as functional foods, nutraceuticals, and food supplements to improve human health and prevent some morbidity. Intriguingly, recent research indicates that probiotics are a promising solution for treating and prophylactic against certain dangerous diseases. Probiotics could also be associated with their essential role in animating the immune system to fight COVID-19 infection. This comprehensive review concentrates on the newest literature on probiotics and their metabolism in treating life-threatening diseases, including immune disorders, pathogens, inflammatory and allergic diseases, cancer, cardiovascular disease, gastrointestinal dysfunctions, and COVID-19 infection. The recent information in this report will particularly furnish a platform for emerging novel probiotics-based therapeutics as cheap and safe, encouraging researchers and stakeholders to develop innovative treatments based on probiotics to prevent and treat chronic and viral diseases.

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“…In a controlled, randomized, double-blinded study, the experimental group who drank beverages containing Lp299v had significantly greater systolic blood pressure, leptin, and fibrinogen than those in the control group, in which a 37% reduction in F2-isoprostaglandin levels and a 42% reduction in IL-6 levels were observed as well (Naruszewicz et al 2002 ). Subsequent studies confirmed that Lp299v possessed a systemic anti-inflammatory effect and reduced the activity of circulatory inflammatory markers, and it was found that the levels of Janus kinase 2, Guanylate-binding protein 1, and TNF superfamily member 10 were reduced in blood after oral Lp299v supplementation (Hofeld et al 2021 ).…”

Section: Introductionmentioning

confidence: 95%

Microarray analysis reveals the potential molecular mechanism of Lp299v in stable coronary atherosclerotic disease

Song

Strömberg

et al. 2022

AMB Expr

View full text Add to dashboard Cite

A growing body of evidence has confirmed that inflammatory mechanisms are involved in the formation and treatment of coronary atherosclerotic disease (CAD). An increase in circulatory levels of inflammatory cytokines has been found in patients with CAD, while the molecular mechanisms of inflammation still remain elusive. This study was designed to identify differentially expressed genes (DEGs), and to explore the molecular mechanism and hub genes that are involved in the effects of Lactobacillus plantarum 299v (Lp299v) supplementation. Microarray dataset (GSE156357) was downloaded from the Gene Expression Omnibus (GEO) database. The DEGs were identified by the R software. Then, the Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses and construction of protein–protein interaction (PPI) network were performed by DAVID, STRING, and Cytoscape software. In daily alcohol user (DAU) group, 7,541 DEGs were identified, including 206 up-regulated and 7,335 down-regulated DEGs. In non-daily alcohol user (non-DAU) group, 2,799 DEGs were identified (2,491 up-regulated and 308 down-regulated DEGs). The GO enrichment analysis revealed that miosis was up-regulated and immune response was down-regulated. The KEGG enrichment analysis showed that Lp299v supplementation reduced the levels of chemotactic cytokines, and weakened immune response. Proteins of G protein-coupled receptor, inflammatory response, regulation of cell proliferation and apoptosis-related proteins were found in the PPI network. The hub genes were associated with G protein-coupled receptor, inflammatory response, and cell proliferation and apoptosis. The weighted gene co-expression network analysis (WGCNA) enriched the DEGs in 4 modules. This study indicated the expressions of chemokine receptors and regulation of immune response in the Lp299v supplementation. Meanwhile, it was supposed that chemokine receptors may have a cellular effect.

show abstract

Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation

Cited by 19 publications

References 54 publications

Microarray Analysis Reveals the Potential Molecular Mechanism of Lp299v in Stable Coronary Atherosclerotic Disease

Microarray Analysis Reveals the Potential Molecular Mechanism of Lp299v in Stable Coronary Atherosclerotic Disease

Probiotic Supplements: Their Strategies in the Therapeutic and Prophylactic of Human Life-Threatening Diseases

Microarray analysis reveals the potential molecular mechanism of Lp299v in stable coronary atherosclerotic disease

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