Lactobacillus plantarum Reduces the In Vitro Secretory Response of Intestinal Epithelial Cells to Enteropathogenic Escherichia coli Infection

Michail, Sonia; Abernathy, Frank

doi:10.1097/00005176-200209000-00021

Cited by 81 publications

(50 citation statements)

References 18 publications

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“…Several mechanisms are considered to be responsible for the beneficial clinical effects of probiotics, including an interaction with pathogenic bacteria (Michail and Abernathy, 2002;Patzer et al, 2003), an increase of the hosts' immune response (Schultz et al, 2002;Zhang et al, 2006;Díaz-Ropero et al, 2007;Schlee et al, 2008) and a production of antimicrobial substances such as organic acids, hydrogen peroxide and bacteriocins (Reid et al, 2003). The observed clinical effects are very likely a combination of a 'direct competition' between pathogenic bacteria and probiotics as well as various beneficial effects on the hosts' immune response (Kligler and Cohrssen, 2008).…”

Section: Discussionmentioning

confidence: 99%

Probiotics affect the clinical inflammatory parameters of experimental gingivitis in humans

et al. 2011

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Objectives: To determine the effects of a probiotic milk drink consumed over a period of 28 days, regarding the expression of clinical inflammatory parameters of the oral gingiva during various phases of plaque-induced gingivitis. Methods: Twenty-eight adults with healthy gingiva took part in a prospective and clinical-controlled study. The test group was advised to consume a probiotic milk drink (Yacult) daily during a period of 4 weeks; the control group did not receive any probiotic food or drink. After 2 weeks of consumption of the probiotic drink, participants were advised not to brush their teeth for 14 days. Subsequently, at baseline as well as on days 1, 3, 5, 7 and 14, the following clinical parameters were assessed: plaque index (PI), gingival index (GI), gingival crevicular fluid (GCF) volume and bleeding on probing (BOP). Results: At baseline, the PI was significantly higher in the test group compared with controls (0.44±0.50 vs 0.09±0.24 PI; P ¼ 0.0001). The termination of oral hygiene increased clinical inflammatory parameters in both groups. At day 14, the parameters PI, GI, GCF volume and BOP were significantly higher compared with baseline values (P ¼ 0.0001). At day 14, BOP levels (18.75 ± 12.32 vs 36.88 ± 12.54%) and GCF volume (18.78 ± 16.7 vs 35.72 ± 16.1 Periotron units) were significantly lower in the test group compared with the control group (P ¼ 0.005). Conclusion:The results of our study indicate that a daily consumption of a probiotic milk drink reduces the effects of plaqueinduced gingival inflammation associated with a higher plaque score due to the high-carbohydrate content of the probiotic milk beverage.

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Section: Discussionmentioning

confidence: 99%

Probiotics affect the clinical inflammatory parameters of experimental gingivitis in humans

et al. 2011

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“…Yeasts, such as Saccharomyces boulardii, have also been studied and are widely used for probiotic purposes (4)(5)(6). The mechanisms responsible for the positive effects of probiotics on the gastrointestinal system are adhesion and colonization to intestinal mucosa, production of antibacterial factors, competition with bacterial substrates, and stimulation of mucosal and systemic immunities (7)(8)(9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

The role of Bifidobacterium lactis B94 plus inulin in the treatment of acute infectious diarrhea in children

İşlek

Sayar²,

Yılmaz³

et al. 2015

Turk J Gastroenterol

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Background/Aims: In contrast to many other studies of probiotic species, the number of publications evaluating Bifidobacterium lactis and its combinations with prebiotics as treatments for acute infectious diarrhea is limited. We investigated the synbiotic effects of B. lactis B94 plus inulin on acute infectious diarrhea. Materials and Methods: The study was conducted on children with acute diarrhea between the ages of 2 and 60 months. The patients were administered 5×10 10 colony-forming units (CFU) of B. lactis B94 plus 900 mg inulin or placebo, once a day for five days. Stools were examined for Rotavirus, Adenovirus, Entamoeba histolytica, Salmonella, Shigella, Campylobacter, Clostridium difficile, Cryptosporidium, and parasites. Results: We examined 79 patients in the synbiotic group and 77 patients in the placebo group. The duration of diarrhea was significantly reduced in the synbiotic group in comparison with the placebo group (3.9±1.2 days vs. 5.2±1.3 days, respectively; p<0.001). Moreover, the number of diarrheal stools on the third day was significantly lower in the synbiotic group than in the placebo group (5.5±2.9 vs. 8.3±3.01, respectively; p<0.001). Diarrhea in the synbiotic-group patients with rotavirus infection was of a significantly shorter duration (3.2±1.3 days vs. 5.2±1.3 days, respectively; p=0.001). Duration of diarrhea in patients who started the synbiotic treatment within the first 24 h was shorter than that in the patients who started the treatment later (3.9±1.1 days vs. 4.8±1.8 days, respectively; p=0.002). Conclusion: Treatment with 5 × 10 10 CFU of B. lactis B94 plus 900 mg inulin shortened the duration of acute watery diarrhea by an average of 31 h. This decrease was most pronounced in cases of Rotavirus diarrhea.

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“…[53,54] Other mechanisms proposed by which probiotics might exert their activity against pathogens are competition for nutrients required for growth of pathogens [55,56] ,competitive inhibition of adhesion of pathogens [57][58][59][60] ,and modification of toxins and toxin receptors. [61,62] …”

Section: Acute Infectious Diarrheamentioning

confidence: 99%

Probiotics in Pediatrics – Properties, Mechanisms of Action, and Indications

Mavroudi¹

2012

Probiotics

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Lactobacillus plantarum Reduces the In Vitro Secretory Response of Intestinal Epithelial Cells to Enteropathogenic Escherichia coli Infection

Abstract: LBP can play an important role in reducing the secretory change in response to EPEC infection, possibly through inhibition of its binding. However, the presence of the probiotic agent before the infection is necessary. In this setting, its role is more preventive rather than therapeutic.

Cited by 81 publications

References 18 publications

Probiotics affect the clinical inflammatory parameters of experimental gingivitis in humans

Probiotics affect the clinical inflammatory parameters of experimental gingivitis in humans

The role of Bifidobacterium lactis B94 plus inulin in the treatment of acute infectious diarrhea in children

Probiotics in Pediatrics – Properties, Mechanisms of Action, and Indications

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