Lactobacillus reuteri derived from horse alleviates Escherichia coli-induced diarrhea by modulating gut microbiota

Wang, Dongjing; Zeng, Jiangyong; Wujin, Cuomu; Ullah, Qudrat; Su, Zhonghua

doi:10.1016/j.micpath.2024.106541

Cited by 4 publications

(1 citation statement)

References 63 publications

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“…the supplementation of Limosilactobacillus reuteri (previously named as Lactobacillus reuteri ) could alleviate Escherichia coli -induced diarrhea and restore the relative abundance of beneficial microbes including Lactobacillus , Bifidobacterium , etc. in mice [ 16 ]. Feeding S accharomyces boulardii mafic 1701 could alleviate intestinal inflammation evidenced by the decreased levels of pro-inflammatory cytokines interleukin-6 and modulate gut microbiota by increasing cecal concentration of microbial metabolites (isobutyrates and valerate) in weaned piglets [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Varied microbial community assembly and specialization patterns driven by early life microbiome perturbation and modulation in young ruminants

Pan,

Ma,

Steele

et al. 2024

ISME Communications

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Perturbations and modulations during early life are vital to affect gut microbiome assembly and establishment. In this study, we assessed how microbial communities shifted during calf diarrhea and with probiotic yeast supplementation (Saccharomyces cerevisiae var. boulardii, SCB) and determined the key bacterial taxa contributing to the microbial assembly shifts using a total of 393 fecal samples collected from 84 pre-weaned calves during an eight-week trial. Our results revealed that the microbial assembly patterns differed between healthy and diarrheic calves at 6-week and 8-week of the trial, with healthy calves being stochastic-driven and diarrheic calves being deterministic-driven. The two-state Markov model revealed that SCB supplementation had a higher possibility to shift microbial assembly from deterministic- to stochastic-driven in diarrheic calves. Furthermore, a total of 23 and 21 genera were specific ecotypes to assembly patterns in SCB-responsive (SCB-fed calves did not exhibit diarrhea) and non-responsive (SCB-fed calves occurred diarrhea) calves, respectively. Among these ecotypes, the area under a receiver operating characteristic curve revealed that Blautia and Ruminococcaceae UCG 014, two unidentified genera from the Ruminococcaceae family, had the highest predictiveness for microbial assembly patterns in SCB-responsive calves, while Prevotellaceae, Blautia, and Escherichia-Shigella were the most predictive bacterial taxa for microbial assembly patterns in SCB-nonresponsive calves. Our study suggests that microbiome perturbations and probiotic yeast supplementation serving as deterministic factors influenced assembly patterns during early life with critical genera being predictive for assembly patterns, which sheds light on mechanisms of microbial community establishment in the gut of neonatal calves during early life.

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Section: Introductionmentioning

confidence: 99%

Varied microbial community assembly and specialization patterns driven by early life microbiome perturbation and modulation in young ruminants

Pan,

Ma,

Steele

et al. 2024

ISME Communications

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Prebiotics enhance the immunomodulatory effect of Limosilactobacillus fermentum DALI02 by regulating intestinal homeostasis

Zhang,

Liu,

Liu

et al. 2024

Food Science & Nutrition

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The colonization ability of Limosilactobacillus fermentum DALI02 and the promoting effect of fermented prebiotics have been studied. This study aims to evaluate the systemic immunomodulatory effects of DALI02 and DALI02 + Prebiotics on cyclophosphamide‐induced immunosuppressed rats. We found that DALI02 and DALI02 + Prebiotics, especially DALI02 + Prebiotics, exhibited significant restorative effects on the immunocompromised state in rats (p < .05). Specifically, both of them promoted the recovery of body weight and immune organ function, enhanced the proliferative capacity of immune cells, and effectively reduced the levels of interleukin 6 (IL‐6) and tumor necrosis factor‐α (TNF‐α). Furthermore, both of them significantly reduced the levels of lipopolysaccharide (LPS) and D‐lactic acid in the blood (p < .05). Principal coordinate analysis (PCoA), principal component analysis (PCA), and unsupervised cluster analysis revealed that DALI02 and DALI02 + Prebiotics group were more similar to the blank group at the genus level of the gut microbiota. At the level of short‐chain fatty acids (SCFAs), DALI02 + Prebiotics and blank group belonged to Cluster 3. These results suggested that the intervention with DALI02 and DALI02 + Prebiotics effectively modulated the structure of the gut microbiota, and DALI02 + Prebiotics restored the dysregulation of SCFAs. In summary, DALI02 and DALI02 + Prebiotics possess immunomodulatory functions, with the latter showing superior effects.

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Double-layer microcapsules based on shellac for enhancing probiotic survival during freeze drying, storage, and simulated gastrointestinal digestion

Zhao,

Mu,

Guo

et al. 2024

International Journal of Biological Macromolecules

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Lactobacillus reuteri derived from horse alleviates Escherichia coli-induced diarrhea by modulating gut microbiota

Cited by 4 publications

References 63 publications

Varied microbial community assembly and specialization patterns driven by early life microbiome perturbation and modulation in young ruminants

Varied microbial community assembly and specialization patterns driven by early life microbiome perturbation and modulation in young ruminants

Prebiotics enhance the immunomodulatory effect of Limosilactobacillus fermentum DALI02 by regulating intestinal homeostasis

Double-layer microcapsules based on shellac for enhancing probiotic survival during freeze drying, storage, and simulated gastrointestinal digestion

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