Lactobionic acid in a natural alkylpolyglucoside‐based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid

Abstract

LA-containing samples has produced better skin performance when compared with corresponding GA-containing ones, particularly the lack of both skin irritation and skin barrier impairment. When used in vehicles based on a new APG-emulsifier, LA and GA have shown better efficacy, emphasizing the importance of vehicle on the effects of topical actives. LA (6%) in the emulsion based on APGs could be proposed as an alternative to low-molecular AHAs in cosmeceuticals.

Evaluation of the efficacy and tolerability of mandelic acid-containing cosmetic formulations for acne skin care

“…However, the number of leave-on cosmetics containing poly-hydroxy acids (PHAs) is increasing [18]. The most common PHAs are glycolic acid, salicylic acid, lactobionic acid, and citric acid (used at concentrations of 1-10% (w/v)) [19][20][21][22]. The data presented herein show that topical application of a cream containing mandelic acid is a safe and effective treatment for acne.…”

Lactobionic acid: A high value-added lactose derivative for food and pharmaceutical applications

“…Pharmaceutical Enhancement of solubility of macrolide antibiotics such as erythromycin and clarithromycin Anti-aging and keratinizing ingredient of skin care cosmetics Calcium supplementation Metal-chelating agent in organ preservation solutions Ingredient in chlorhexidine-based disinfectant Bio-surfactant in its fatty acid derivatives forms Inducer for cellulase production by Trichoderma reesei Functional molecule in the synthesis of polymeric nanoparticles for liver-specific drug deliver (Ahamed & Vermette, 2008;Frutos et al, 1997;Green et al, 2009;Jain & Jain, 2010;Playne & Crittenden, 2009;Van Hecke et al, 2011) Food Acidulant with a sweet taste Filler in cheese production Firming agent Calcium carrier in functional drinks Reduction of souring and ripening time for the production of cheese and yogurt Enhancement of flavors Improvement of bitter or sour taste of foods Preservation of aroma freshness Preparation of dairy products with reduced lactose content (Gerling, 1998;Merrill & Singh, 2009;Nakano et al, 2010;Nordkvist et al, 2007;Playne & Crittenden, 2009) Chemical Ion sequestrant in detergent solutions Biodegradable cobuilder in washing powder Anti-corrosive coatings Chiral selector for enantiomeric separation of basic drugs in capillary electrophoresis (clarithromycin lactobionate) Reactant for synthetic amides (Gerling, 1998;Yu et al, 2011) Nanotechnology Part of biocompatible scaffolds for tissue engineering Part of nanoplatforms for new bioimaging applications Ingredient of galactose-conjugated fluorescent nanoparticles for immunofluorescence assays (Chung et al, 2002;Kekkonen et al, 2009;Peng et al, 2007) volunteers periodically over two weeks (Tasic-Kostov et al, 2010). LBA could increase the synthesis of glycosaminoglycans in the skin, and it has been shown to enhance cell turnover in vitro (Briden & Green, 2005).…”

Effects of Cosmetic Formulations Containing Hydroxyacids on Sun-Exposed Skin: Current Applications and Future Developments

“…Recently, Tasic-Kostov et al [18] conducted a study to assess the safety and efficacy of lactobionic acid as compared to glycolic acid. Seventy-seven volunteers participated in the project, and skin color (erythema and melanin index), transepidermal water loss, electrical capacitance, and pH of the skin were measured.…”