Lactocrine Programming

Bartol, Frank F.; Bagnell, Carol A.

doi:10.1016/b978-0-12-801238-3.64699-8

Encyclopedia of Reproduction 2018

DOI: 10.1016/b978-0-12-801238-3.64699-8

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Lactocrine Programming

Frank F. Bartol¹,

Carol A. Bagnell²

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2019

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Cited by 2 publications

References 57 publications

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Development and Function of Uterine Glands in Domestic Animals

Spencer

Kelleher

Bartol

2019

Annu. Rev. Anim. Biosci.

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All mammalian uteri contain glands that synthesize or transport and secrete substances into the uterine lumen. Uterine gland development, or adenogenesis, is uniquely a postnatal event in sheep and pigs and involves differentiation of glandular epithelium from luminal epithelium, followed by invagination and coiling morphogenesis throughout the stroma. Intrinsic transcription factors and extrinsic factors from the ovary and pituitary as well as the mammary gland (lactocrine) regulate uterine adenogenesis. Recurrent pregnancy loss is observed in the ovine uterine gland knockout sheep, providing unequivocal evidence that glands and their products are essential for fertility. Uterine gland hyperplasia and hypertrophy during pregnancy are controlled by sequential actions of hormones from the ovary and/or pituitary as well as the placenta. Gland-derived histotroph is transported by placental areolae for fetal growth. Increased knowledge of uterine gland biology is expected to improve pregnancy outcomes, as well as the health and productivity of mothers and their offspring. Expected final online publication date for the Annual Review of Animal Biosciences Volume 7 is February 15, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Development and Function of Uterine Glands in Domestic Animals

Spencer

Kelleher

Bartol

2019

Annu. Rev. Anim. Biosci.

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Uterine Glands: Developmental Biology and Functional Roles in Pregnancy

2019

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All mammalian uteri contain glands in the endometrium that develop only or primarily after birth. Gland development or adenogenesis in the postnatal uterus is intrinsically regulated by proliferation, cell–cell interactions, growth factors and their inhibitors, as well as transcription factors, including forkhead box A2 (FOXA2) and estrogen receptor α (ESR1). Extrinsic factors regulating adenogenesis originate from other organs, including the ovary, pituitary, and mammary gland. The infertility and recurrent pregnancy loss observed in uterine gland knockout sheep and mouse models support a primary role for secretions and products of the glands in pregnancy success. Recent studies in mice revealed that uterine glandular epithelia govern postimplantation pregnancy establishment through effects on stromal cell decidualization and placental development. In humans, uterine glands and, by inference, their secretions and products are hypothesized to be critical for blastocyst survival and implantation as well as embryo and placental development during the first trimester before the onset of fetal–maternal circulation. A variety of hormones and other factors from the ovary, placenta, and stromal cells impact secretory function of the uterine glands during pregnancy. This review summarizes new information related to the developmental biology of uterine glands and discusses novel perspectives on their functional roles in pregnancy establishment and success.

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Lactocrine Programming

Cited by 2 publications

References 57 publications

Development and Function of Uterine Glands in Domestic Animals

Development and Function of Uterine Glands in Domestic Animals

Uterine Glands: Developmental Biology and Functional Roles in Pregnancy

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