Lactoferrin Alleviates the Progression of Atherosclerosis in ApoE^−/− Mice Fed with High-Fat/Cholesterol Diet Through Cholesterol Homeostasis

Dietary lactoferrin has differential effects on gut microbiota in young versus middle-aged APPswe/PS1dE9 transgenic mice but no effects on cognitive function

“…Oscillibacter has been negatively associated with body mass index or postprandial glucose levels in humans (33). The elevated Oscillibacter post Lf intervention in young APP/PS1 mice could suggest that Lf might be beneficial for metabolic parameters, which have been reported by our laboratory previously (22,23). However, it should be realized our GTT and ITT results did not support the beneficial effects of Lf at least on glucose and insulin metabolism.…”

“…Secondly, Liu et al (32) demonstrated that apo-Lf might show better neuroprotective effects on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinson's disease mouse model than holo-Lf. The Lf used in our study had an iron content of 0.028% (23), which means it is a form of Lf existed between holo-Lf and apo-Lf; therefore, different forms of Lf might result in variable effects on cognitive function. Nevertheless, further studies are still required to explore the effects of Lf intervention on cognition via different AD mouse models with specific emphasis on different forms of Lf with varied dosages.…”

“…Over the intervention periods, the average daily dietary intake per mice was roughly 4 g/day; thus the average daily Lf intake was about 32 mg/d. The selection of the above dosage for Lf was based on findings from our (22,23) and other (24) research groups. Water and specific food were allowed for mice ad libitum.…”

Lactoferrin—The Health-Promoting Properties and Contemporary Application with Genetic Aspects

“…It exerts a beneficial effect on lipid metabolism and reduces the concentration of total and LDL cholesterol. The positive correlation between a higher serum concentration of bLF and a lower BMI suggests that LF can be used to prevent cardiovascular disease [57].…”

“…In addition, LF exhibits strong antihypertensive activity, as it blocks angiotensin receptor AT1 and inhibits the renin-angiotensin-aldosterone system [63]. Ling et al [57] conducted a study to test the effect of bLF supplementation on the development of atherosclerosis in mice. The mice were divided into three groups, one of which received distilled water (HFCD), whereas the other two received a solution of bLF at a concentration of 2 mg/mL (MLF) or 10 mg/mL (HLF).…”