Lactoferrin and Iron Absorption in Newborn Infants

Fairweather‐Tait, Susan J.; Balmer, S E; Scott, Peter; Minski, M.J.

doi:10.1203/00006450-198712000-00007

Cited by 77 publications

(23 citation statements)

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“…Iron absorption decreases with age (28), probably due to maturational changes in intestinal transport mechanisms. This most likely explains why several studies on older infants (1 1, 14) indicate lower absorption values from unfortified formula than our study and that of Fairweather-Tait et al (26). Numerous iron bioavailability studies have been done with human adults.…”

Section: Methodscontrasting

confidence: 49%

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Iron Retention from Lactoferrin-Supplemented Formulas in Infant Rhesus Monkeys

1990

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ABSTRACT. Iron absorption from human milk and infant formula has received much attention, but experimental design problems have been common. In our study, iron retention from human milk, milk-based infant formula (IF) with and without supplemental ferrous sulfate, and IF supplemented with either human or bovine lactoferrin (Lf) was evaluated in infant rhesus monkeys. The exchange of 59Fe (111) C13 between the whey, casein, and fat fractions required up to 72 h to reach the same distribution as intrinsic iron, depending on the type of diet. Infant monkeys were intubated with labeled human milk or IF and counted in a whole body counter. Each infant received all five diets and was also intubated with a reference dose of 55Fe (11) The study of iron absorption from IF has received much attention in recent years. Interest began as a result of the observation that breast-fed infants maintain adequate iron status through 6-9 mo of age, whereas formula-fed infants consuming similar amounts of iron require iron supplementation by about 4 mo (1, 2). Siimes et al. (3) found that none of 36 exclusively breast-fed infants exhibited iron deficiency anemia at 9 mo. Iron status of these infants was similar to a control group receiving iron supplemented formula (6 mg/L). In contrast, low birth wt infants, born with significantly lower iron stores, require iron supplementation at an earlier age. In a study of 15 exclusively breast-fed preterm infants, Iwai et al. (4) found that about 60% showed signs of iron deficiency at 4 mo, and 86% were iron deficient at 6 mo.A number of studies have attempted to determine the bioavailability of iron from various milks and formulas. These studies conclude that iron absorption from cow milk-based formulas is low, 5-20%, whereas iron uptake from human milk is

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Section: Methodscontrasting

confidence: 49%

“…A recent study by Fairweather-Tait et al (26) compared iron absorption from a commercial cow's milk-based formula containing either femc chloride plus ascorbate, or bovine Lf as the iron source. Iron retention in 7-d-old human infants was not significantly different between the two groups.…”

Section: Methodsmentioning

confidence: 99%

Iron Retention from Lactoferrin-Supplemented Formulas in Infant Rhesus Monkeys

1990

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“…A lack of intracellular iron may evoke increased expression of specific receptors on the surface of enterocytes and thereby elevated absorption of lactoferrin-bound iron (Suzuki et al, 2005). Breast-fed infants have demonstrated better iron accessibility than babies on formula (Fairweather-Tait et al, 1987). Counter to this, some research fails to identify a positive effect of lactoferrin on iron absorption in the intestines.…”

Section: Lactoferrin and Iron Metabolismmentioning

confidence: 99%

Lactoferrin: a review

Adlerova¹,

Bartošková²,

Faldyna³

2008

Vet. Med.

267

217

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This review discusses the biological properties of the glycoprotein lactoferrin. Lactoferrin has been identified in secretions from exocrine glands and in specific granules of neutrophils. After degranulation, neutrophils become the main source of lactoferrin in blood plasma. Lactoferrin possesses various biological functions, including roles in iron metabolism, cell proliferation and differentiation, and antibacterial, antiviral, and antiparasitic activity. Many of these functions do not appear to be connected with its iron binding ability. Of late, lactoferrin concentrations have been measured mostly in humans but also in some other species. However, the relationship between its concentration and physiological or pathological effects on body functions is not yet well characterised.

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“…Infants (7-d-old) fed on formula supplemented with 58 Fe-labelled bovine lactoferrin were entered into 3 d Fe balance studies. There was a very wide variation in Fe retention amongst the infants but no overall difference between those receiving the lacto-ferrin and control formula-fed infants without lactoferrin (Fairweather-Tait et al 1987). In a second study several 24 h balance studies were performed on infants (born at term) between 3 and 17 weeks of age who received formula supplemented with 1 g bovine lactoferrinal.…”

Section: Role Of Lactoferrin In Iron Absorptionmentioning

confidence: 99%

Iron fortification of infant formula

Moy

2000

Nutr. Res. Rev.

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The purpose of this review is to examine the need for and appropriate level of Fe forti®cation of infant formula, and to assess any adverse effects of Fe forti®cation. The appropriate level of Fe forti®cation of infant formula has been established through studies of Fe absorption or erythrocyte incorporation of Fe, and through clinical trials of formulas with varying levels of Fe that were aimed at preventing the development of Fe de®ciency in participating infants. In addition, the effects of varying levels of Fe forti®cation on the absorption of other minerals and trace elements, and on the incidence of infection and immune function have been studied, as has the effect of adding bovine lactoferrin to formula. Studies

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Lactoferrin and Iron Absorption in Newborn Infants

Cited by 77 publications

References 1 publication

Iron Retention from Lactoferrin-Supplemented Formulas in Infant Rhesus Monkeys

Iron Retention from Lactoferrin-Supplemented Formulas in Infant Rhesus Monkeys

Lactoferrin: a review

Iron fortification of infant formula

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