Lactose

Shendurse, A.M.; Khedkar, C. D.

doi:10.1016/b978-0-12-384947-2.00415-3

Cited by 16 publications

(13 citation statements)

References 6 publications

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“…The water retention is attributed to the hygroscopic nature of LBA [ 28 ]. Shendurse and Khedkar [ 29 ] have also emphasized that LBA is hygroscopic and forms a gel containing around 14% water. X-ray diffractometry was performed in the research of Bisinella et al [ 30 ], who found that stored unpacked LBA presented a decrease in crystallinity, which was attributed to high LBA hygroscopicity (with low angles at 2θ: 18.96° and 19.34°).…”

Section: Resultsmentioning

confidence: 99%

Downstream Approach Routes for the Purification and Recovery of Lactobionic Acid

Sarenkova

Sáez‐Orviz

Rendueles

et al. 2022

Foods

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The successful development of a lactobionic acid (LBA) bioconversion process on an industrial scale demands the selection of appropriate downstream methodological approaches to achieve product purification once the bioconversion of LBA is completed. These approaches depend on the nature of the substrate available for LBA production, and their necessary implementation could constitute a drawback when compared to the lesser effort required in downstream approaches in the production of LBA obtained by chemical synthesis from refined lactose. Thus, the aim of this research is to separate LBA from an acid whey substrate after bioconversion with Pseudomonas taetrolens. Freeze drying, crystallization, adsorption with activated carbon, microfiltration, centrifugation, and precipitation with 96% (v/v) ethanol were carried out to separate and purify LBA. The closest product to commercial LBA was obtained using precipitation with ethanol, obtaining a white powder with 95 ± 2% LBA concentration. The procedure described in this paper could help to produce LBA on an industrial scale via microbial bioconversion from acid whey, developing a promising biotechnological approach for lactose conversion.

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Section: Resultsmentioning

confidence: 99%

Downstream Approach Routes for the Purification and Recovery of Lactobionic Acid

Sarenkova

Sáez‐Orviz

Rendueles

et al. 2022

Foods

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“…The significant CMA affecting the dissolution of the dapagliflozin l -proline tablet was a 2 (lactose). When the tablet containing lactose comes in contact with water, water easily gets into the tablet because hydrophilic lactose has water-absorbing properties [ 56 ]. The effect of CMAs on the intrinsic dissolution rate (b 8 ) was described as a coded equation with a quadratic mathematical model.…”

Section: Resultsmentioning

confidence: 99%

“…This can occur when a tablet containing lactose comes into contact with water; moreover, water easily permeates into the tablet because lactose has water–absorbing properties. As a result, the rate of water penetration into the tablet is high [ 56 ].…”

Section: Resultsmentioning

confidence: 99%

Development of a Robust Control Strategy for Fixed-Dose Combination Bilayer Tablets with Integrated Quality by Design, Statistical, and Process Analytical Technology Approach

et al. 2021

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Control strategy and quality by design (QbD) are widely used to develop pharmaceutical products and improve drug quality; however, studies on fixed-dose combination (FDC) bilayer tablets are limited. In this study, the bilayer tablet consisted of high-dose metformin HCl in a sustained-release layer and low-dose dapagliflozin l-proline in an immediate-release layer. The formulation and process of each layer were optimized using the QbD approach. A d-optimal mixture design and response surface design were applied to optimize critical material attributes and critical process parameters, respectively. The robust design space was developed using Monte Carlo simulations by evaluating the risk of uncertainty in the model predictions. Multivariate analysis showed that there were significant correlations among impeller speed, massing time, granule bulk density, and dissolution in the metformin HCl layer, and among roller pressure, ribbon density, and dissolution in the dapagliflozin l-proline layer. Process analytical technology (PAT) was used with in–line transmittance near-infrared spectroscopy to confirm the bulk and ribbon densities of the optimized bilayer tablet. Moreover, the in vitro drug release and in vivo pharmacokinetic studies showed that the optimized test drug was bioequivalent to the reference drug. This study suggested that integrated QbD, statistical, and PAT approaches can develop a robust control strategy for FDC bilayer tablets by implementing real-time release testing based on the relationships among various variables.

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“…Lactulose is a synthetically produced non-digestible ketose disaccharide that consists of galactose and fructose linked by a bond resistant to lactase [ 113 ]. Lactulose is extracted from lactose (milk sugar), chemically known as 4-O-β-d-galactopyranosyl-d-fructose, and the enzyme used for the biocatalytic production is β-galactosidase [ 114 ].…”

Section: Classification Of Prebioticsmentioning

confidence: 99%

Prebiotics as a Tool for the Prevention and Treatment of Obesity and Diabetes: Classification and Ability to Modulate the Gut Microbiota

Megur

Daliri

Baltriukienė

et al. 2022

IJMS

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Diabetes and obesity are metabolic diseases that have become alarming conditions in recent decades. Their rate of increase is becoming a growing concern worldwide. Recent studies have established that the composition and dysfunction of the gut microbiota are associated with the development of diabetes. For this reason, strategies such as the use of prebiotics to improve intestinal microbial structure and function have become popular. Consumption of prebiotics for modulating the gut microbiota results in the production of microbial metabolites such as short-chain fatty acids that play essential roles in reducing blood glucose levels, mitigating insulin resistance, reducing inflammation, and promoting the secretion of glucagon-like peptide 1 in the host, and this accounts for the observed remission of metabolic diseases. Prebiotics can be either naturally extracted from non-digestible carbohydrate materials or synthetically produced. In this review, we discussed current findings on how the gut microbiota and microbial metabolites may influence host metabolism to promote health. We provided evidence from various studies that show the ability of prebiotic consumption to alter gut microbial profile, improve gut microbial metabolism and functions, and improve host physiology to alleviate diabetes and obesity. We conclude among other things that the application of systems biology coupled with bioinformatics could be essential in ascertaining the exact mechanisms behind the prebiotic–gut microbe–host interactions required for diabetes and obesity improvement.

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Lactose

Cited by 16 publications

References 6 publications

Downstream Approach Routes for the Purification and Recovery of Lactobionic Acid

Downstream Approach Routes for the Purification and Recovery of Lactobionic Acid

Development of a Robust Control Strategy for Fixed-Dose Combination Bilayer Tablets with Integrated Quality by Design, Statistical, and Process Analytical Technology Approach

Prebiotics as a Tool for the Prevention and Treatment of Obesity and Diabetes: Classification and Ability to Modulate the Gut Microbiota

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