Lactose and cataract in humans: a review.

Couet, Charles; Jan, P; Debry, G

doi:10.1080/07315724.1991.10718130

Cited by 7 publications

(2 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Galactose and lactose are not always desirable in food products, because of lactose intolerance, and the involvement of galactose in cataract occurrence in certain individuals in combination with alcohol intake [ 85 ]. These considerations led to an attempt to engineer L. lactis into a glucose-producing cell factory.…”

Section: Identification Of Existing and Novel Biochemical Routesmentioning

confidence: 99%

Genome Analysis of Food Grade Lactic Acid-Producing Bacteria: From Basics to Applications

Mayo

Sinderen²,

Ventura³

2008

View full text Add to dashboard Cite

Whole-genome sequencing has revolutionized and accelerated scientific research that aims to study the genetics, biochemistry and molecular biology of bacteria. Lactic acid-producing bacteria, which include lactic acid bacteria (LAB) and bifidobacteria, are typically Gram-positive, catalase-negative organisms, which occupy a wide range of natural plant-and animal-associated environments. LAB species are frequently involved in the transformation of perishable raw materials into more stable, pleasant, palatable and safe fermented food products. LAB and bifidobacteria are also found among the resident microbiota of the gastrointestinal and/or genitourinary tracts of vertebrates, where they are believed to exert health-promoting effects. At present, the genomes of more than 20 LAB and bifidobacterial species have been completely sequenced. Their genome content reflects its specific metabolism, physiology, biosynthetic capabilities, and adaptability to varying conditions and environments. The typical LAB/bifidobacterial genome is relatively small (from 1.7 to 3.3 Mb) and thus harbors a limited assortment of genes (from around 1,600 to over 3,000). These small genomes code for a broad array of transporters for efficient carbon and nitrogen assimilation from the nutritionally-rich niches they usually inhabit, and specify a rather limited range of biosynthetic and degrading capabilities. The variation in the number of genes suggests that the genome evolution of each of these bacterial groups involved the processes of extensive gene loss from their particular ancestor, diversification of certain common biological activities through gene duplication, and acquisition of key functions via horizontal gene transfer. The availability of genome sequences is expected to revolutionize the exploitation of the metabolic potential of LAB and bifidobacteria, improving their use in bioprocessing and their utilization in biotechnological and health-related applications.

show abstract

Section: Identification Of Existing and Novel Biochemical Routesmentioning

confidence: 99%

Genome Analysis of Food Grade Lactic Acid-Producing Bacteria: From Basics to Applications

Mayo

Sinderen²,

Ventura³

2008

View full text Add to dashboard Cite

show abstract

“…The osmotic phenomenon of galactitol causes swelling within lens fiber cells and eventually leads to cataract formation. Galactose metabolism is suspected to be related to cataractogenesis in the presence of complete (as well as partial) enzyme deficiency in the galactose metabolic pathway, high adult jejunal lactase activity, and/or large consumption of lactose (Couet et al 1991). Age-related cataract is a mul-…”

mentioning

confidence: 99%

A Genetic Factor for Age-Related Cataract: Identification and Characterization of a Novel Galactokinase Variant, “Osaka,” in Asians

Okano

Asada

Fujimoto

et al. 2001

The American Journal of Human Genetics

View full text Add to dashboard Cite

Galactokinase (GALK) deficiency is an autosomal recessive disorder characterized by hypergalactosemia and cataract formation. Through mass screening of newborn infants, we identified a novel and prevalent GALK variant (designated here as the "Osaka" variant) associated with an A198V mutation in three infants with mild GALK deficiency. GALK activity and the amount of immunoreactive protein in the mutant were both 20% of normal construct in expression analysis. The K(m) values for galactose and ATP-Mg(2+) in erythrocytes with homozygous A198V were similar to those of the healthy adult control subjects. A population study for A198V revealed prevalences of 4.1% in Japanese and 2.8% in Koreans, lower incidence in Taiwanese and Chinese, no incidence in blacks and whites from the United States, and a significantly high frequency (7.8%; P < .023) in Japanese individuals with bilateral cataract. This variant probably originated in Japanese and Korean ancestors and is one of the genetic factors that causes cataract in elderly individuals.

show abstract

Galactokinase

Huang

Stambolian

2002

Wiley Encyclopedia of Molecular Medicine

View full text Add to dashboard Cite

Lactose and cataract in humans: a review.

Cited by 7 publications

References 58 publications

Genome Analysis of Food Grade Lactic Acid-Producing Bacteria: From Basics to Applications

Genome Analysis of Food Grade Lactic Acid-Producing Bacteria: From Basics to Applications

A Genetic Factor for Age-Related Cataract: Identification and Characterization of a Novel Galactokinase Variant, “Osaka,” in Asians

Galactokinase

Contact Info

Product

Resources

About