Lactose intolerance, calcium intake, and osteopenia

Mainguet, P.; Faille, I.; Destrebecq, Laurence; Devogelaer, Jean‐Pierre; Deuxchaisnes, C Nagant de

doi:10.1016/0140-6736(91)92024-v

Cited by 20 publications

(10 citation statements)

References 6 publications

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“…Such effects are likely to be population specific. Thus, in the British Women's Heart and Health Study, a prospective cohort study of women born in Britain in the 1920s and 1930s [85], lactase-persistent genetic variants, which have been shown in other populations to be related to milk consumption [86][87][88], are not related to whether the women avoid milk (Davey Smith G, Lawlor DA et al, unpublished data, available from authors). While this lack of association might be related to measurement error in our assessment of milk consumption, it is also conceivable that in women of this generation, who experienced food rationing during the second world war and for some years afterwards, any gastrointestinal discomfort resulting from lactose intolerance is ignored because of the previous social pressures not to be a 'fussy eater'.…”

Section: Social Pressures On Behaviours Affected By Genotypementioning

confidence: 99%

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

Lawlor

Harbord

Sterne

et al. 2008

Statistics in Medicine

3,514

3,153

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Observational epidemiological studies suffer from many potential biases, from confounding and from reverse causation, and this limits their ability to robustly identify causal associations. Several high-profile situations exist in which randomized controlled trials of precisely the same intervention that has been examined in observational studies have produced markedly different findings. In other observational sciences, the use of instrumental variable (IV) approaches has been one approach to strengthening causal inferences in non-experimental situations. The use of germline genetic variants that proxy for environmentally modifiable exposures as instruments for these exposures is one form of IV analysis that can be implemented within observational epidemiological studies. The method has been referred to as 'Mendelian randomization', and can be considered as analogous to randomized controlled trials. This paper outlines Mendelian randomization, draws parallels with IV methods, provides examples of implementation of the approach and discusses limitations of the approach and some methods for dealing with these.

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Section: Social Pressures On Behaviours Affected By Genotypementioning

confidence: 99%

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

Lawlor

Harbord

Sterne

et al. 2008

Statistics in Medicine

3,514

3,153

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“…On the other hand, lactose intolerance is known to cause maldigesters to avoid dairy products 22 . Notably, higher dairy intake is associated with lower fat mass in postmenopausal women 12 .…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, lactose intolerance is known to cause maldigesters to avoid dairy products. 22 Notably, higher dairy intake is associated with lower fat mass in postmenopausal women. 12 The daily consumption of dairy products results in significant reductions in body fat mass in obese humans in the absence of caloric restriction and markedly accelerates the weight and body fat loss.…”

Section: Discussionmentioning

confidence: 99%

Adult‐type hypolactasia and calcium intake in polycystic ovary syndrome

Lerchbaum¹,

Gruber

Pieber³

et al. 2012

Clinical Endocrinology

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“…Patients with lactose intolerance are expected to avoid milk and milk products, which, in fact, also reduce clinical symptoms, e.g., diarrhea and intestinal calcium loss. [10][11][12] The similarity of symptoms, e.g., abdominal pain, flatulence, and watery stool and the resultant incorrect diagnosis of IBD might explain the refractory nature of the condition in some patients.…”

Section: Discussionmentioning

confidence: 99%