Lamina Cribrosa Depth in Healthy Eyes

Seo, Je Hyun; Kim, Tae Woo; Weinreb, Robert N.

doi:10.1167/iovs.13-12536

Cited by 62 publications

(51 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Existing in vivo studies on LC morphology using OCT vary in their scanning methodologies, ranging from several radial scans 7,10 to just a few horizontal or vertical scans. 5,13,14 Since the principal directions appear to be aligned along the N-T and S-I cross sections, our finding suggests that scans along these two cross sections alone may be sufficient in calculating LC-GSI and estimating anterior LC shape. A comparison of the original LC-GSI values computed using the entire reconstructed LC and a new estimate based on just the N-T and S-I cross sections showed very good agreement (Pearson's correlation R ¼ 0.92).…”

Section: 13mentioning

confidence: 77%

“…The direction of association of LC depth with sex and axial length is consistent with a previous finding. 14 The association of LC depth with BMO-MRW and VCDR in healthy eyes has not been reported previously. Bruch's membrane opening-MRW has been shown to be more accurate than neuroretinal rim width measured from fundus images.…”

Section: Distribution and Determinants Of Lc Depthmentioning

confidence: 82%

“…5). Previous studies have reported the LC to have a central ridge 13,14 and a corresponding U or W shape.…”

Section: Distribution and Determinants Of Lc-gsimentioning

confidence: 99%

“…Previous studies have reported the variation of LC depth among healthy and glaucomatous eyes using in vivo spectraldomain optical coherence tomography (SD-OCT) imaging. 13,14 Park et al 13 reported the presence of a central ridge in the LC and lower insertion points in the superior-inferior (S-I) cross section. Other studies have also shown the LC to be U-or Wshaped.…”

mentioning

confidence: 99%

See 3 more Smart Citations

A Global Shape Index to Characterize Anterior Lamina Cribrosa Morphology and Its Determinants in Healthy Indian Eyes

Thakku

Tham

Baskaran

et al. 2015

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Citation: Thakku SG, Tham Y-C, Baskaran M, et al. A global shape index to characterize anterior lamina cribrosa morphology and its determinants in healthy Indian eyes. Invest Ophthalmol Vis Sci. 2015;56:3604-3614. DOI:10.1167/iovs.15-16707 PURPOSE. Lamina cribrosa (LC) morphology could be implicated in the progression of glaucoma. To date, no established, quantifiable parameter to assess LC shape in vivo exists. We aim to introduce a new global shape index for the anterior LC (LC-GSI) and to identify associations with ocular factors in a healthy Indian population. METHODS.Optical coherence tomography (OCT) scans of the optic nerve head (ONH) were performed on 162 healthy subjects. Optic nerve head structures were delineated and a geometric characterization of anterior LC morphology was obtained by measuring curvature along 180 LC cross sections and representing it as LC-GSI ranging from À1 to þ1. Lamina cribrosa depth and curvature were also reported. Linear regression was used to identify factors associated with LC morphology.RESULTS. The typical healthy LC had a saddle rut-like appearance, with a central ridge visible in superior-inferior cross sections. A more prominent central ridge (larger LC-GSI) was associated with shorter axial length (P < 0.001), smaller Bruch's membrane opening (BMO) area (P ¼ 0.020), smaller vertical cup-to-disc ratio (VCDR) (P ¼ 0.007), and larger minimum rim width (BMO-MRW) (P ¼ 0.001). A deeper LC was associated with male sex (P < 0.001), shorter axial length (P ¼ 0.003), larger VCDR (P < 0.001), and smaller BMO-MRW (P ¼ 0.002). Age and IOP were not significantly associated with LC morphology in healthy eyes.CONCLUSIONS. The LC-GSI is a single index that quantifies overall LC shape in an intuitive way. Ocular determinants of LC-GSI in healthy eyes included risk factors for glaucoma (axial length, VCDR, and BMO-MRW), highlighting the potential role of LC morphological characterization in the diagnosis and monitoring of glaucoma.Keywords: lamina cribrosa morphology, optic nerve head, optical coherence tomography A major site of retinal ganglion cell (RGC) damage in glaucoma is at the optic nerve head (ONH), where RGC axons congregate before making their way to the brain. [1][2][3] Within the ONH, RGC axons pass through a mesh-like collagen fiber structure called the lamina cribrosa (LC), before exiting the eye.Lamina cribrosa morphology and progression of glaucoma are believed to be closely related. 4 In particular, glaucomatous onset is associated with posterior displacement of the anterior LC surface, 5-7 posterior migration of the LC insertion points, 6 and backward bowing of the entire LC. 8 Nonhuman primate models of glaucoma have also shown similar associations. 9-11Furthermore, these models suggest that LC changes precede surface level retinal nerve fiber layer (RNFL) thinning, 11,12 which is a useful marker of glaucoma onset. Taken together, these findings indicate that an assessment of LC morphology may potentially be used as a biomarker for early glaucoma detection. The...

show abstract

Section: 13mentioning

confidence: 77%

Section: Distribution and Determinants Of Lc Depthmentioning

confidence: 82%

“…5). Previous studies have reported the LC to have a central ridge 13,14 and a corresponding U or W shape.…”

Section: Distribution and Determinants Of Lc-gsimentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

A Global Shape Index to Characterize Anterior Lamina Cribrosa Morphology and Its Determinants in Healthy Indian Eyes

Thakku

Tham

Baskaran

et al. 2015

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Using SDOCT, it is also now possible to obtain images of deep ocular structures including the lamina cribrosa, the putative site of retinal ganglion cell damage in glaucoma (Burgoyne et al, 2005;Lee et al, 2014;Park et al, 2012;Seo et al, 2014;Sigal et al, 2014). The lamina cribrosa is a meshwork of connective tissue through which retinal ganglion cell axons pass as they exit the eye through the scleral canal.…”

Section: What Is the Earliest Detectable Change?mentioning

confidence: 99%

Strategies to improve early diagnosis in glaucoma

Tatham¹,

Medeiros²,

Zangwill³

et al. 2015

Progress in Brain Research

Self Cite

View full text Add to dashboard Cite

Early diagnosis and treatment of glaucoma is important to reduce the risk of progressive and irreversible visual loss. The key to diagnosis is recognition of morphological changes to the optic nerve head and retinal nerve fiber layer, but in some patients, functional abnormalities are detected first. This review describes recent innovations with the potential to improve the early detection of glaucoma. Developments in imaging include novel optic nerve head metrics such as Bruch's membrane opening-minimum rim width, enhanced ability to quantify inner layers of the glaucomatous macula, and ability to image deep optic nerve head structures, including the lamina cribrosa. Developments in detection of early glaucomatous functional loss include novel perimetric tests using frequency-doubling technology and flicker-defined form stimuli. Methods to combine results of structural and functional assessments are also presented that may improve early detection of glaucoma. KeywordsGlaucoma, Optical coherence tomography, OCT, Perimetry, Spectral domain, Early diagnosis Glaucoma is a leading cause of blindness, affecting more than 70 million people worldwide, of whom approximately 10% are bilaterally blind (Quigley and Broman, 2006). Glaucomatous visual losses can be prevented with early diagnosis and treatment; however, affected individuals are typically asymptomatic until later stages of the disease and a large proportion of those affected remain undiagnosed. Population-level surveys suggest only 10-50% of people with glaucoma are aware that they have the condition and consequently there are a large number of people Progress in Brain Research, Volume 221, ISSN 0079-6123, http://dx

show abstract

Computational Simulation of the Human Eye with Glaucoma to Identify Early Changes in Anterior Segment

Rosales,

Bazan,

Barba-Gallardo

2023

IFMBE Proceedings

View full text Add to dashboard Cite

Lamina Cribrosa Depth in Healthy Eyes

Abstract: This study reports the range of ALCS depth in healthy subjects. These data suggest that ALCS depth is related to sex and axial length.

Cited by 62 publications

References 38 publications

A Global Shape Index to Characterize Anterior Lamina Cribrosa Morphology and Its Determinants in Healthy Indian Eyes

A Global Shape Index to Characterize Anterior Lamina Cribrosa Morphology and Its Determinants in Healthy Indian Eyes

Strategies to improve early diagnosis in glaucoma

Computational Simulation of the Human Eye with Glaucoma to Identify Early Changes in Anterior Segment

Contact Info

Product

Resources

About