Lamina Cribrosa Thickness and Spatial Relationships between Intraocular Space and Cerebrospinal Fluid Space in Highly Myopic Eyes

Jonas, Jost B.; Berenshtein, Eduard; Holbach, Leonard M.

doi:10.1167/iovs.03-1363

Cited by 312 publications

(225 citation statements)

References 32 publications

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“…This has been presented as an explanation for the increased susceptibility to glaucoma in highly myopic eyes. 27 In the current study, no correlation was found between AL and structural changes. This study has some limitations.…”

Section: Discussioncontrasting

confidence: 68%

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Barrancos

Rebolleda

Oblanca

et al. 2013

Eye

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Aim To determine the response of the lamina cribrosa (LC) and prelaminar tissue to a reduction of intraocular pressure (IOP) after nonpenetrating deep sclerectomy (NPDS) using enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT). Methods A total of 28 eyes from 28 patients presenting with primary open angle glaucoma who underwent NPDS were studied. SD-OCT scans using EDI technology were obtained before surgery and 1 week, 1 month, and 3 months postoperatively. The OCT device was set to image a 15 Â 101 vertical rectangle centred on the optic disc. The scan closest to the optic nerve head (ONH) centre was selected for analysis. The vertical distances from three equidistant points on the reference line (Bruch's membrane opening) to the anterior prelaminar tissue surface and the anterior and posterior surfaces of the LC were measured. Results The IOP decreased from 18.7 ± 4.3 to 9.1±4.0 at the first week, 11.4±3.7 at 1 month, and 13.1±3.6 mm Hg at 3 months postoperatively (Po0.001). There was a significant reduction of the ONH cupping at 1 week (22.3%, Po0.001), 1 month (13.7%, Po0.001), and 3 months (9.8%, P ¼ 0.001) after surgery. Anterior displacement of the LC was slight but statistically significant at 1 week (4.5%, P ¼ 0.003), 1 month (3.8%, P ¼ 0.014), and 3 months postoperatively (3.3%, P ¼ 0.010). IOP reduction was significantly correlated with a reduction of ONH cupping and anterior displacement of LC at the first week and first month (Po0.05). Conclusions Cupping reversal after NPDS is mainly due to changes in prelaminar tissue thickness, whereas the LC changes in position are less pronounced.

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Section: Discussioncontrasting

confidence: 68%

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Barrancos

Rebolleda

Oblanca

et al. 2013

Eye

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“…Indeed, the translaminar gradient is not only affected by the IOP and the retrolaminar pressure, but also by the thickness of the wall separating these compartments. An abnormally thin sclera, as suggested to exist in NTG patients [21], could dramatically increase the pressure gradient over this supporting tissue [22], even with pressures in the retroocular compartments within an otherwise normal range. This could then result in an increased stress on the optic nerve in these patients.…”

Section: Discussionmentioning

confidence: 98%

Intraocular pressure correlates with optic nerve sheath diameter in patients with normal tension glaucoma

Pinto

Vandewalle

Pronk

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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Purpose 1. Identify differences in optic nerve sheath diameter (ONSD) as an indirect measure of intracranial pressure (ICP) in glaucoma patients and a healthy population. 2. Identify variables that may correlate with ONSD in primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG) patients. Methods Patients with NTG (n046) and POAG (n061), and healthy controls (n042) underwent B-scan ultrasound measurement of ONSD by an observer masked to the patient diagnosis. Intraocular pressure (IOP) was measured in all groups, with additional central corneal thickness (CCT) and visual field defect measurements in glaucomatous patients. Only one eye per patient was selected. Kruskal-Wallis or Mann-Whitney were used to compare the different variables between the diagnostic groups. Spearman correlations were used to explore relationships among these variables. Results ONSD was not significantly different between healthy, NTG and POAG patients (6.09±0.78, 6.03±0.69, and 5.71±0.83 respectively; p00.08). Visual field damage and CCT were not correlated with ONSD in either of the glaucoma groups (POAG, p00.31 and 0.44; NTG, p00.48 and 0.90 respectively). However, ONSD did correlate with IOP in NTG patients (r00.53, p<0.001), while it did not in POAG patients and healthy controls (p00.86, p00.46 respectively). Patient's age did not relate to ONSD in any of the groups (p>0.25 in all groups). Conclusions Indirect measurements of ICP by ultrasound assessment of the ONSD may provide further insights into the retrolaminar pressure component in glaucoma. The correlation of ONSD with IOP solely in NTG patients suggests that the translaminar pressure gradient may be of particular importance in this type of glaucoma.

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“…The secondary thinning of the lamina cribrosa occurs and may lead to an increased risk of glaucoma. 15 Wells et al 11 showed the relationship between the cornea and the optic disc in vivo using Heidelberg Retina Tomography II (Heidelberg Engineering, GmbH, Dossenheim, Germany). According to their results, corneal hysteresis, but not CCT or other anterior segment parameters, was associated with increased deformation of the optic nerve surface during transient elevations of IOP.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14][15] Nevertheless, in vivo clinical clues regarding the correlated parameters of the lamina cribrosa are limited. 13,16 We hypothesised that the presence of lamina cribrosa in optic nerve roots outside the eye may correlate with the optic disc area.…”

Section: Introductionmentioning

confidence: 99%

The relationship between the cornea and the optic disc

Kim

Park

Kim

et al. 2010

Eye

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Objective To evaluate the structural relationship between the cornea and the optic disc in normal subjects. Methods This hospital-based observational study included 205 eyes from 205 individuals who were diagnosed as normal at our glaucoma clinic. The subjects underwent an eye examination, optic disc imaging with optic disc photography, optical coherence tomography, IOL master, specular microscopy, and ultrasound corneal pachymetry. Results In univariate regression models (Pearson's correlation coefficient), the cup-to-disc (CD) ratio showed a negative correlation with corneal curvature (r ¼ À0.315, Po0.001) and central corneal thickness (r ¼ À0.206, P ¼ 0.005), and a positive correlation with white-to-white diameter (horizontal limbus to limbus distance, r ¼ 0.215, P ¼ 0.003). In multiple linear regression models with CD ratio as the dependant parameter, the CD ratio was still significantly associated with corneal curvature (b ¼ À0.205, P ¼ 0.011) and white-to-white diameter (b ¼ 0.207, P ¼ 0.010). The central corneal thickness failed to show statistical significance, but did show a negative correlation with borderline significance (b ¼ À0.133, P ¼ 0.075). Conclusions Eyes with a large CD ratio have large and flat corneas; this may suggest that there is a structural relationship between the cornea and the optic disc. These results can be helpful in analysing the anatomical relationship between the cornea and the optic disc.

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Lamina Cribrosa Thickness and Spatial Relationships between Intraocular Space and Cerebrospinal Fluid Space in Highly Myopic Eyes

Cited by 312 publications

References 32 publications

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Intraocular pressure correlates with optic nerve sheath diameter in patients with normal tension glaucoma

The relationship between the cornea and the optic disc

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