Landiolol decreases a dysrhythmogenic dose of epinephrine in dogs during halothane anesthesia

Takahashi, Shinji; Fujii, Yoshitaka; Inomata, Shinichi; Miyabe, Masayuki; Toyooka, Hidenori

doi:10.1007/bf03013554

Cited by 10 publications

(6 citation statements)

References 16 publications

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“…We have previously demonstrated that epinephrine causes dysrhythmias in halothane-anesthetized dogs, and that 10 µg·kg -1 ·min -1 landiolol prevents such dysrhythmias. 17 In this study, the dose of 1 µg·kg -1 ·min -1 landiolol controlled dysrhythmias associated with theophylline intoxication.…”

Section: Discussionmentioning

confidence: 82%

Modifications of the hemodynamic consequences of theophylline intoxication with landiolol in halothane-anesthetized dogs

Takahashi

Fujii

Hoshi

et al. 2000

Can J Anesth/J Can Anesth

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Purpose: To examine the effect of landiolol (ONO-1101), a new ultra-short acting, highly selective beta 1 blocker, on hemodynamic response to acute theophylline intoxication in anesthetized dogs.Methods: Thirty-four dogs were studied during halothane anesthesia. Aminophylline (50 mg·kg -1 over 20 min followed by infusion at 1.75 mg·kg -1 ·hr -1 ) was administered as a model of acute theophylline intoxication. Dogs were randomly enrolled into four landiolol groups (0, 1, 10, 100 µg·kg -1 ·min -1 ) to treat tachyarrhythmias. Hemodynamic variables, heart rate (HR), systemic blood pressure (SBP), pulmonary artery pressure, pulmonary artery occlusion pressure, and cardiac output (CO) were measured along with plasma concentrations of theophylline, epinephrine, and norepinephrine. Results: After 60 min, plasma concentration of theophylline reached 46.6 ± 4.0 (mean ± SD) µg·ml -1 , HR increased from 129 ± 21 to 193 ± 27 bpm (P < 0.0001) and CO increased from 1.6 ± 0.5 l·min -1 to 2.1 ± 0.4 l·min -1 (P < 0.0001), whereas SBP decreased from 139 ± 25 to 121 ± 25 mm Hg (P < 0.0001), with decreasing systemic vascular resistance. After intoxication, plasma epinephrine concentration increased from 125 ± 112 to 325 ± 239 pg·ml -1 (P < 0.0001), and norepinephrine concentration from 103 ± 61 to 133 ± 61 pg·ml -1 (P < 0.0011). Landiolol 10 µg·kg -1 ·min -1 decreased HR to pre-intoxication level, whereas HR returned to the intoxication baseline by 30 min after cessation of landiolol infusion. Conclusions: Landiolol controlled tachyarrhythmias associated with theophylline toxicity. The optimal effective dose of landiolol was 10 µg·kg -1 ·min -1 .Objectif : Examiner l'effet du landiolol (ONO-1101), nouveau bloqueur beta 1 hypersélectif à action ultrabrève, sur la réponse hémodynamique de l'intoxication aiguë à la théophylline chez des chiens anesthésiés. Méthode : L'étude a porté sur 34 chiens anesthésiés à l'halothane. L'aminophylline (50 mg·kg -1 pendant 20 min, suivi d'une perfusion à 1,75 mg·kg -1 ·hr -1 ) a été administrée pour provoquer l'intoxication aiguë à la théophylline. Les chiens, répartis au hasard en quatre groupes, ont reçu différentes doses de landiolol (0, 1, 10, 100 µg·kg -1 ·min -1 ) pour traiter la tachyarythmie. On a mesuré : la fréquence cardiaque (FC), la pression sanguine systémique (PSS), la pression artérielle pulmonaire, la pression artérielle pulmonaire bloquée et le débit cardiaque (DC) de même que les concentrations plasmatiques de théophylline, d'épinéphrine et de norépinéphrine. Résultats : Après 60 min, la concentration plasmatique de théophylline était de 46,6 ± 4,0 (moyenne ± écart type) µg·ml -1 , la FC avait augmenté de 129 ± 21 à 193 ± 27 bpm (P < 0,0001) et le DC était passée de 1,6 ± 0,5 l·min -1 à 2,1 ± 0,4 l·min -1 (P < 0,0001), tandis que la PSG avait baissé de 139 ± 25 à 121 ± 25 mm Hg (P < 0,0001) et que la résistance vasculaire générale diminuait. Après l'intoxication, la concentration plasmatique d'épinéphrine a augmenté de 125 ± 112 à 325 ± 239 pg·ml -1 (P < 0,0001), et la concentratio...

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Section: Discussionmentioning

confidence: 82%

Modifications of the hemodynamic consequences of theophylline intoxication with landiolol in halothane-anesthetized dogs

Takahashi

Fujii

Hoshi

et al. 2000

Can J Anesth/J Can Anesth

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“…In fact, most beta-blockers, including landiolol, have antiarrhythmic properties. Landiolol decreased the dysrhythmogenic dose of epinephrine in dogs [12], and restored sinus rhythm in patients with supraventricular or ventricular tachycardia [2]. Although there is no case report describing the conversion of atrial fibrillation due to landiolol, esmolol was reported to accelerate the conversion of recent-onset atrial fibrillation compared with diltiazem and verapamil [13,14].…”

Section: Discussionmentioning

confidence: 98%

Conversion of atrial fibrillation to sinus rhythm during landiolol infusion

et al. 2004

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A 71-year-old woman with a history of persistent atrial fibrillation underwent clipping of a ruptured cerebral artery aneurysm. During the surgery her cardiac rhythm was atrial fibrillation and the ventricular rate increased to 130 beats.min(-1). Administration of landiolol was started with 1-min loading infusion at 0.125 mg.kg(-1).min(-1) and continuous infusion at 0.04 mg.kg(-1).min(-1), which was effective in controlling the ventricular rate without causing hypotension. Approximately 120 min after the landiolol infusion was started, the atrial fibrillation was converted to sinus rhythm. Her sinus rhythm was maintained until she left the operating room, even after discontinuation of landiolol.

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“…7,8 While landiolol is more potent than esmolol 7 in terms of chronotropy, it also has less effects on blood pressure than esmolol in anesthetized rabbits. 9 Although there have been great advances in cardiac surgical techniques in the past decade, postoperative support with inotropic agents is still frequently necessary.…”

Section: Contexte : L'usage Clinique De Fortes Doses Thérapeutiques Dmentioning

confidence: 99%

“…Animal preparation was similar to that described previously. 8,13 Animals were anesthetized with 25 mg·kg -1 pentobarbital iv, the trachea intubated with a cuffed tracheal tube, and the lungs ventilated mechanically. Anesthesia was maintained with 1. were randomly assigned according to computer-generated random numbers into one of two groups (n = 9 in each): 1) a milrinone group, or 2) a control (normal saline) group.…”

Section: Me Et Th Ho Od Ds Smentioning

confidence: 99%

Milrinone attenuates the negative inotropic effects of landiolol in halothane-anesthetized dogs

Takahashi

Fujii

Hoshi

et al. 2003

Can J Anesth/J Can Anesth

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B Ba ac ck kg gr ro ou un nd d: : Clinical use of high dose beta-blocker therapy is limited by excessive negative inotropic effects. Previous studies suggest that milrinone may be of utility in limiting the inotropic but not the chronotropic effects of beta blockers. We examined the hemodynamic effects of co-administration of a new potent selective beta 1 blocker, landiolol, and milrinone in halothane-anesthetized dogs.M Me et th ho od ds s: : Eighteen adult mongrel dogs were anesthetized with 1.2 MAC halothane. Hemodynamic measurements were made at baseline, 30 min after starting the milrinone (0.5 µg·kg -1 ·min -1 ) or normal saline infusion (n = 9 in each), then 30 min after each change in the dose of landiolol infusion. The tested doses of landiolol were 10, 100, and 1000 µg·kg -1 ·min -1 .

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Landiolol decreases a dysrhythmogenic dose of epinephrine in dogs during halothane anesthesia

Cited by 10 publications

References 16 publications

Modifications of the hemodynamic consequences of theophylline intoxication with landiolol in halothane-anesthetized dogs

Modifications of the hemodynamic consequences of theophylline intoxication with landiolol in halothane-anesthetized dogs

Conversion of atrial fibrillation to sinus rhythm during landiolol infusion

Milrinone attenuates the negative inotropic effects of landiolol in halothane-anesthetized dogs

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