Landscape assessment for gender neutral human papillomavirus vaccination recommendations including head and neck cancer burden data

Morais, Edith; Mouaddin, Nadia El; Schuurman, Susanne; De, Atish

doi:10.1016/j.vaccine.2021.08.043

Cited by 7 publications

(11 citation statements)

References 34 publications

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“…As of April 2019, 32 countries had recommended gender-neutral vaccination programs, and the number is growing. Most are western countries, including the United States, Germany, and Italy [ 28 ]. Our data show that the economic burden associated with HNC in males is 4.5 times higher in direct medical costs and 6.7 times higher in productivity loss compared with CC in females in Taiwan.…”

Section: Discussionmentioning

confidence: 99%

Economic Burden of Cervical and Head and Neck Cancer in Taiwan from a Societal Perspective

Wu¹,

Lai

Chien³

et al. 2023

IJERPH

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Background: Head and neck cancers (HNC) are increasingly recognized as important human papillomavirus (HPV)-related malignancies in addition to cervical cancer (CC). However, data on the socioeconomic impact of HNC and CC in Taiwan are limited. Methods: A retrospective cohort study was conducted to estimate the total direct medical cost and indirect productivity loss from CC and HNC between 2014 and 2015. Patient data from the Taiwan National Cancer Registry were analyzed, with matched non-cancer controls from the Taiwan National Healthcare Reimbursement Database. Indirect costs due to premature deaths were calculated using public data from Taiwanese government reports. Results: In the direct cost analysis, 2083 patients with newly diagnosed CC and 11,078 with newly diagnosed HNC (10,036 males) were identified between 2014 and 2015 and followed up through the end of 2016 or until death. The total direct medical costs incurred in 2014 and 2015 due to HNC were 11.54 times higher in males than in females, and 4.55 times higher than CC. Indirect cost analysis showed the total annual productivity loss was New Taiwan Dollar (NTD) $12 billion in 2019, and 79.99% was attributed to male HNC. Conclusion: In Taiwan, the socioeconomic burden associated with male HNC is high and greater than that seen with CC. While not all HNCs are attributable to HPV infection, prevention of HNC through HPV vaccination should be considered for both sexes.

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Section: Discussionmentioning

confidence: 99%

Economic Burden of Cervical and Head and Neck Cancer in Taiwan from a Societal Perspective

Wu¹,

Lai

Chien³

et al. 2023

IJERPH

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“…All of the studies agreed that while data may be lacking in the exact pathogenesis of HPV- associated OPC, the use of pangender HPV-vaccination was beneficial both from a cost-effectiveness standpoint as well as a risk/benefit standpoint, particularly in higher income countries [ 13 , 23 – 29 ]. While some have argued that men may be sheltered from HPV-related sequelae such as OPC with herd immunity, data suggests that 80–90% of women would have to receive the HPV vaccine to achieve this, which is likely unattainable, particularly in low and middle income countries [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…The included studies have given rise to the following themes: a link between HPV and OPC; a potential benefit to the vaccination of men to reduce rates of OPC and the likely cost-effectiveness of pangender HPV-vaccination [ 13 , 23 – 29 ]. These themes will be discussed further below.…”

Section: Main Textmentioning

confidence: 99%

The effectiveness of HPV vaccination on the incidence of oropharyngeal cancers in men: a review

Macilwraith

Malsem

Dushyanthen

2023

Infect Agents Cancer

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Background Human Papilloma Virus (HPV) contributes to the development of oropharyngeal cancer (OPC) and is currently the leading cause of OPC in the Western world. There have been limited studies examining the effect of HPV-vaccination on OPC incidence in men. This review aims to interrogate relationship linking HPV-vaccination and OPC in men, to potentially recommend pangender HPV-vaccination, to reduce the incidence of HPV associated OPC. Main Body A review was carried out using Ovid Medline, Scopus and Embase databases, on 22nd October 2021 investigating the effect of HPV-vaccination on OPC prevalence in men and including studies with vaccination data pertaining to men in the past 5 years, while excluding those studies without appropriate oral HPV-positivity data and non-systematic reviews. Studies were evaluated as per the PRISMA guidelines and ranked using risk of bias tools including RoB-2, ROBINS-1 and the NIH quality assessment tools. 7 studies were included ranging from original research to systematic review articles. All studies were published in English from 2017 to 2021. Overall, these suggested that HPV-vaccination reduced levels of oral HPV positivity in men. This was thought to be indicative of a reduced risk of development of HPV-associated OPC. A limitation of this study was the inability to conduct meta-analysis due to the heterogeneity of included studies. We noted a significant impact on the reduction of HPV positivity post HPV-vaccination and a potential contribution to reducing the future incidence of OPC. Conclusion This review makes a strong case for pangender HPV-vaccination in combatting OPC in men.

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“…28,29 Notably, the prevalence of oral HPV 16 and 18 infections in the US is reduced by approximately 88.2% in vaccinated versus unvaccinated individuals (0.11% versus 1.61% for all individuals; 0.0% versus 2.13% for men). [30][31][32][33] HPV vaccines are prophylactic and do not treat HPV-related diseases or prevent their progression. 6 Due to the extensive latency period between HPV infection and cancer development, the eff ect of vaccination implementation for HNC is not expected to be seen for decades.…”

Section: ■ Hpv 9-valent Vaccinementioning

confidence: 99%

HPV vaccination for prevention of head and neck cancer among men

El Hussein,

Dhaliwal

2023

The Nurse Practitioner

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The incidence of human papillomavirus (HPV)-associated head and neck cancer (HNC) has been rapidly increasing in developed countries, with HPV-associated HNC now accounting for 70% of all HNC cases. An increased incidence has been noted particularly among males. The disparities in HPV vaccine uptake rates and the increasing number of individuals with HPV-associated HNC suggest a lack of public awareness of both HPV sequelae and prevention options. This review highlights the importance of prophylactic HPV vaccination for preventing HPV-associated HNC, particularly in males. Current evidence substantiates the need for gender-neutral HPV vaccination programs and reinforces the recommendations made by the CDC. This article raises awareness of the association between HPV and HNC as well as the effectiveness of HPV vaccination in HNC prevention.

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Landscape assessment for gender neutral human papillomavirus vaccination recommendations including head and neck cancer burden data

Cited by 7 publications

References 34 publications

Economic Burden of Cervical and Head and Neck Cancer in Taiwan from a Societal Perspective

Economic Burden of Cervical and Head and Neck Cancer in Taiwan from a Societal Perspective

The effectiveness of HPV vaccination on the incidence of oropharyngeal cancers in men: a review

HPV vaccination for prevention of head and neck cancer among men

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