Langaside, a novel secoiridolactone glycoside derivative from Tachiadenus longiflorus Griseb. (Gentianaceae) formed by a [2+2] cycloaddition reaction

Pseudopulchellol: A unique sesquiterpene-monoterpene derived C-25 terpenoid from the leaves of Croton pseudopulchellus Pax (Euphorbiaceae)

“…2). In addition, two structures of pseudopulchellol including the (+)-pinene ( 1) and (-)-pinene (1a) moieties were modelled following the protocol we have reported previously (Langat et al, 2014;Tembu et al, 2015) and their simulated ECD curves (Frisch et al, 2010) were compared to the experimental data for pseudopulchellol (Fig. 3) and this confirmed that the (+)-pinene moiety was a constituent pseudopulchellol.…”

Novel Bioactive Natural Products Isolated from Madagascar Plants and Marine Organisms (2009–2017)

“…Compound 167 displayed strong antimitotic activity (IC 50 =26.4 nM) when tested in a modified cell-based immunoassay using the specific mitotic marker MPM-42, suggesting that it may target microtubules by an unusual mechanism. 54) Langaside (168), a secoiridoid lactone glucoside possessing a novel skeleton formed by a [2+2] cycloaddition reaction between the secoiridolactone glucoside 1,9-trans-9,5-cis-sweroside and p-coumaric acid, was isolated from the fruits and flowers of Malagasy Tachiadenus longiflorus GRISEB. (Gentianaceae), along with seven known compounds.…”