Langerhans' Cell Granule

The role of langerhans cells in contact allergy. I. An ultrastructural study in actively induced contact dermatitis in guinea pigs

“…Our finctings in guinca pigs reinforce our previous observation in man that Langerhans cells, for which no function had hitherlo been found, serve a func tion in contact-allergic reactions ( I 2). Previously it has been suggested that Langerhans cells may have a role in processing antigen (7,11). Our observation tend to support the concept that Langerhan� cells may have a function in someways analogous to macrophagcs, i.e., in their ability to retain antigen.…”

Apposition of mononuclear cells to langerhans cells in contact allergic reactions. An ultrastructural study

“…The first is uptake and processing of allergenic material by the Langerhans cells with transfer of an immunologically active fragment to mono nuclear ce lls, presumably lymphocytes. Ln this way Langerhans cells would act like macrophages (5). The second is related to the finding\ of Wolff (17) and Sagebiel (10) that Langerhans cells may take up materials such as thorotrast and ferritin, but 1hat they do l>O less erficiently than do kera tinocytcs.…”

Granules of Langerhans cells in Letterer-Siew's disease

“…The presence of such active cell� in the cell infiltrates. togethcr with previou� findings of mitotic figure� (7), con firms the neoplastic nature of Letterer-Siwe's clis ease.…”

“…There are two theories on the formation of granules. According to one, the granulc formation takes place in the Golgi zonc (14) while the other considers infolding of the cell-membrane to be the first step of the formation process (7,9). The present findings of incomplcte granules around the Golgi zone suggest a close relationship bc tween these organelles.…”

“…Another single membrane separated the central space from the bulge wall (Figs. 6,7,8). Glyco gen particles were observed in the central space of bulges (Fig.…”