Langerhans’ Cell Histiocytosis Involving the Pituitary, Thyroid, Lung, and Liver

Sampathkumar, Sujatha; Younger, Cheryl; Cramer, Harvey; Chalasani, Naga; Skierczynski, Paul

doi:10.4158/ep.8.3.217

Cited by 15 publications

(9 citation statements)

References 14 publications

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“…In adults, sclerosing cholangitis, as a late complication in Langerhans cell histiocytosis, has only been described in a few cases associated with poor prognosis, high mortality and LT as the only therapeutic option. (121,(124)(125)(126)(127)(128)(129)(130).…”

Section: Causes Of Secondary Sclerosing Cholangitismentioning

confidence: 99%

Evolving concepts in primary sclerosing cholangitis

Krones

Graziadei

Trauner

et al. 2011

Liver International

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Keywords autoimmune sclerosing cholangitis -children -IgG4-associated sclerosing cholangitisinflammatory bowel diseases -primary sclerosing cholangitis -sclerosing cholangitis in critically ill patients -secondary sclerosing cholangitis AbstractPatients suffering from primary sclerosing cholangitis (PSC) show considerable differences regarding clinical manifestations (i.e. large duct versus small-duct PSC, presence or absence of concomitant inflammatory bowel disease), disease progression, risk for malignancy and response to therapy, raising the question whether PSC may represent a mixed bag of diseases of different aetiologies. The growing list of secondary causes and diseases 'mimicking' or even overlapping with PSC (e.g. IgG4-associated sclerosing cholangitis), which frequently causes problems in clear-cut discrimination from classic PSC and the emerging knowledge about potential disease modifier genes (e.g. variants of CFTR, TGR5 and MDR3) support such a conceptual view. In addition, PSC in children differs significantly from PSC in adults in several aspects resulting in distinct therapeutic concepts. From a clinical perspective, appropriate categorization and careful differential diagnosis are essential for the management of concerned patients. Therefore, the aim of the current review is to summarize current and evolving pathophysiological concepts and to provide up-to-date perspectives including future treatment strategies for PSC.

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Section: Causes Of Secondary Sclerosing Cholangitismentioning

confidence: 99%

Evolving concepts in primary sclerosing cholangitis

Krones

Graziadei

Trauner

et al. 2011

Liver International

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“…Suspected causative agents include infectious agents and immunodysfunction that give rise to abnormal proliferation of histiocytes. Related lymphocyte infiltration, cytokines and genetic factors have also been reported to be associated with the pathogenesis of eosinophilic pseudotumors in visceral organs . One pediatric study reported a rate of liver involvement of 15.6% in 217 cases.…”

Section: Discussionmentioning

confidence: 99%

“…Related lymphocyte infiltration, cytokines and genetic factors have also been reported to be associated with the pathogenesis of eosinophilic pseudotumors in visceral organs. [8][9][10][11][12][13] One pediatric study 14 reported a rate of liver involvement of 15.6% in 217 cases. The published literatures contain only two small series of adult liver LCH 10,15 and isolated cases.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic pseudotumor of the liver: Report of six cases and review of literature

Zhang

Weng

Dong

et al. 2015

J of Digest Diseases

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“…Liver involvement in adult LCH is relatively rare (6)(7)(8). Nagai et al reported 1 case of adult LCH with liver involvement (8) and reviewed 5 previously reported adult cases (9)(10)(11)(12)(13).…”

Section: Discussionmentioning

confidence: 99%