Langerhans' cell histiocytosis of the temporal bone in an adult with central diabetes insipidus

Abstract

We present a case of Langerhans’ cell histiocytosis in a 40-year-old woman presenting with central diabetes insipidus and right ear pain. As this disease process is often clinically challenging, the presence of certain imaging findings should raise the possibility of this diagnosis. We review the pertinent imaging and correlate with histology and immunohistochemistry leading to the diagnosis.

Langerhans Cell Histiocytosis of the Temporal Bone in Children: Two Cases Report

“…We report the case of a 2-year-old child with HCL with bilateral temporal bone involvement associated with central pituitary involvement responsible for diabetes insipidus. Rare similar cases have been reported [7]- [9].…”

Langerhans Cell Histiocytosis of the Temporal Bone in a Child with Central Diabetes Insipidus

“…We report the case of a 2-year-old child with LH with bilateral temporal bone involvement associated with central pituitary involvement responsible for diabetes insipidus. Rare cases with similar presentation have been reported [8][9][10].…”

Intradural Langerhans' Cell Histiocytosis Invading Frontal Bone of Skull: A Case Report with A Brief Review

“…The disease process is, therefore, usually classified as three clinical variations based on organ involvement. These categories are named as eosinophilic granuloma, usually a solitary osseous lesion; Hand Schuller-Christian disease, the chronic recurrent form, which classically shows a triad of a skull lesion, exophthalmos, and diabetes insipidus; and the fulminant formation named as Letterer Siwe disease-multiple organ involvement [8][9][10].…”