Langerhans Cells in Murine Vaginal Epithelium Affected by Oestrogen and Topical Vitamin A

Young, William G.; Hosking, Annette R.

doi:10.1159/000146137

Cited by 9 publications

(4 citation statements)

References 6 publications

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“…9,10 The pleotropic effects of estrogen on the epithelium of the reproductive tract are thought to facilitate and enhance C. albicans adhesion, growth and colonization. 8,11,12 Several investigators have used estrogen in conjunction with C. albicans vaginal inoculation to construct animal models of persistent VC; among these models is the estrogen-dependent VC (EDVC) murine model. [13][14][15] This model has proved to be useful in evaluating the various aspects of pathogenesis of VC as VC in the absence of estrogen treatment in the murine system is transient and only lasts for few days.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, estriols, pregnanediols, pregnanetrials and estradiols have been shown to increase germination of C. albicans 9,10 . The pleotropic effects of estrogen on the epithelium of the reproductive tract are thought to facilitate and enhance C. albicans adhesion, growth and colonization 8,11,12 . Several investigators have used estrogen in conjunction with C. albicans vaginal inoculation to construct animal models of persistent VC; among these models is the estrogen‐dependent VC (EDVC) murine model 13–15 .…”

Section: Introductionmentioning

confidence: 99%

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Estrogen‐dependent induction of persistent vaginal candidosis in naïve mice

Hamad

Abu-Elteen

Ghaleb

2004

Mycoses

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The capacity of estrogen to induce vaginal candidosis (VC) in the absence of previous or concurrent Candida albicans infections was examined. Adult female Balb/c mice were evaluated for vaginal C. albicans burden, C. albicans-specific delayed type hypersensitivity (DTH) responses and vaginal lymphocyte population kinetics at several time-points while receiving weekly injections of 0.5 mg estrogen. Estrogen treatment resulted in the appearance of significant levels of C. albicans vaginal colonization, which persisted for a period of 4 weeks. A marked suppression of DTH responses mounted against subsequent C. albicans challenge was observed. Absolute number of vaginal T lymphocytes gradually increased by several folds especially at weeks 5-6 following the start of estrogen treatment. These results clearly indicate that estrogen, independent of other predisposing factors, is capable of perturbing the commensal relationship between the host and the fungus, which results in the induction of persistent VC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Estrogen‐dependent induction of persistent vaginal candidosis in naïve mice

Hamad

Abu-Elteen

Ghaleb

2004

Mycoses

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“…This phenomenon also occurs in rat (Parakkal, 1974;Centola, 1978;Vijayasaradhi & Gupta, 1987) and mouse (Allen, 1927;Young & Hosking, 1986;Nelson et al, 1991;Horvat et al, 1992). The acquisition of secretory activity, changes in the pattern of keratinization, and an increase in the rate of mitosis were also seen.…”

Section: Discussionmentioning

confidence: 79%

Morphological changes in the vaginal epithelium during the oestrous cycle of Calomys callosus (Rodentia, Cricetidae)

Rodrigues

Ferro

1998

Rev. Bras. Biol.

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This study describes changes in the pattern of microridges, keratinization, desquamation, secretion, leukocyte infiltration as well as the increasing number of mitotic cells in the vaginal epithelium of Calomys callosus during the oestrous cycle. In proestrus, the epithelium is squamous and stratified with a fine layer of keratin and it is overlain by secretory prismatic cells. In oestrous, the epithelium is squamous, stratified and keratinized. In metoestrus, the epithelium is squamous and stratified with loss of the keratin layer. A leukocyte infiltration, extending from the base to the surface of the epithelial layer is also present. At the end of this phase, the surface cells start to become PAS-positive. In dioestrus, the epithelium is stratified. The superficial cells are prismatic, exhibiting the structural and ultrastructural characteristics of glycoprotein secreting cells supported by a layer of squamous cells. At the end of this phase, kerato-hyaline granules appear in the granular layer of the epithelium, indicating the beginning of the keratinization process, present in the next proestrus.Key words: oestrous cycle, vaginal epithelium, Calomys callosus, keratinization, secretion, leukocyte infiltration. RESUMO

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“…Sex hormones may also directly influence DC/LC by modulating their morphology, density, distribution, maturity and function (Kaushic et al, 1998;Komi et al, 2001;Koyama et al, 1989;Wira et al, 2000;Young and Hosking, 1986). More specifically, sex hormones have been shown to influence the distribution of DC in the epithelium of rat reproductive tract (Kaushic et al, 1998).…”

Section: Role Of Sex Hormones On the Cervical Immune Microenvironmentmentioning

confidence: 99%

Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix

Delvenne

Herman

Kholod

et al. 2007

Molecular and Cellular Endocrinology

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If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the induction of squamous metaplasia in the transformation zone of the cervix, interactions between steroid hormones and HPV gene expression and alterations of the local immune microenvironment.

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Langerhans Cells in Murine Vaginal Epithelium Affected by Oestrogen and Topical Vitamin A

Cited by 9 publications

References 6 publications

Estrogen‐dependent induction of persistent vaginal candidosis in naïve mice

Estrogen‐dependent induction of persistent vaginal candidosis in naïve mice

Morphological changes in the vaginal epithelium during the oestrous cycle of Calomys callosus (Rodentia, Cricetidae)

Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix

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