1997
DOI: 10.1007/978-1-4757-9966-8_21
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Langerhans Cells Require Signals from Both Tumour Necrosis Factor α and Interleukin 1β for Migration

Abstract: The induction phase of contact sensitization is associated with the movement of epidermal Langerhans cells (LC ) from the skin and their migration, via afferent lymphatics, to draining lymph nodes where they accumulate as immunostimulatory dendritic cells (DC ). It has been demonstrated previously that tumour necrosis factor-a ( TNF-a) provides an important signal for LC migration and that in the absence of this cytokine, movement of LC from the epidermis to regional lymph nodes is inhibited. Recent evidence i… Show more

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Cited by 128 publications
(197 citation statements)
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“…Upon maturation, LCs emigrate from the epidermis with the help of inflammatory cytokines such as tumor necrosis factor-α and interleukin-1β (Stoitzner et al , 1999; Cumberbatch et al , 1997). Given the activation of LCs on day 2, OT-I cells were extracted directly from the dermis of the K14-mOVA(6) Tg mouse ears on day 2 following i.d.…”
Section: Resultsmentioning
confidence: 99%
“…Upon maturation, LCs emigrate from the epidermis with the help of inflammatory cytokines such as tumor necrosis factor-α and interleukin-1β (Stoitzner et al , 1999; Cumberbatch et al , 1997). Given the activation of LCs on day 2, OT-I cells were extracted directly from the dermis of the K14-mOVA(6) Tg mouse ears on day 2 following i.d.…”
Section: Resultsmentioning
confidence: 99%
“…During HSV-2 infection in vivo, IL-1β facilitates the recruitment of neutrophiles to inflammatory sites [19], [20]. TNF-α stimulates differentiation of NK cells but together with IL-1β also enhances Langerhans cells migration from the epithelium of mice [21]. CXCL1 expression is up-regulated in the vagina and CNS of mice during acute HSV-2 infection [22] and this chemokine specifically targets neutrophils through the receptor CXCR2 promoting chemotaxis and activation of neutrophils [23].…”
Section: Discussionmentioning
confidence: 99%
“…Cross-talk between keratinocytes and Langerhans cells via these innate immune signals induces activation, maturation, and migration of antigen-presenting cells to draining lymph nodes. The importance of IL-1β and TNF-α in induction of Langerhans cell migration from the epidermis has been demonstrated in skin contact sensitization models and in experimental cutaneous Leishmania infections (31, 32). Our analysis of cytokine expression in the skin following insertion of antigen-coated microneedles indicates the upregulation of IL-1β, TNF-α, and MIP-1α and supports the current models of Langerhans cell migration.…”
Section: Discussionmentioning
confidence: 99%