Langmuir monolayers of the long-chain alkyl derivatives of a nucleoside analogue and the formation of self-assembled nanoparticles

Jin, Yiguang; Qiao, Yingxin; Li, Miao; Ai, Ping; Hou, Xinwen

doi:10.1016/j.colsurfb.2005.02.001

Cited by 24 publications

(17 citation statements)

References 33 publications

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“…An injection method was used to prepare the self-assemblies of derivatives in water according to our previous work [5,10]. The derivatives were dissolved in a water-miscible organic solvent, tetrahydrofuran (THF).…”

Section: Injection Methods For Molecular Self-assembly In Watermentioning

confidence: 99%

“…1). They were one fatty acyl derivative of INH (1), three fatty alcohol derivatives of INH with a succinyl spacer (2, 3 and 4) and one THTT derivative of INH with an alkyl chain (5). The processes of synthesis and identifications were described as follows.…”

Section: Synthesis Of the Lipid Derivatives Of Inhmentioning

confidence: 99%

“…The lipid derivatives of a nucleoside analogue, acyclovir as an antiviral agent, were synthesized. And one of these amphiphilic prodrugs self-assembled into cuboid-shaped nanoparticles in water based on intermolecular hydrophobic interaction and hydrogen bonding [5]. More importantly, the self-assembled nanoparticles delivered themselves in vivo and showed significant site-specific distribution, and the active parent drugs were released in a sustained profile at the targeted sites, depending on the degradation rate of lipid prodrugs [6].…”

Section: Introductionmentioning

confidence: 99%

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Monolayers of the lipid derivatives of isoniazid at the air/water interface and the formation of self-assembled nanostructures in water

Jin¹,

Chen

Xin³

et al. 2008

Colloids and Surfaces B: Biointerfaces

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Section: Injection Methods For Molecular Self-assembly In Watermentioning

confidence: 99%

Section: Synthesis Of the Lipid Derivatives Of Inhmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Monolayers of the lipid derivatives of isoniazid at the air/water interface and the formation of self-assembled nanostructures in water

Jin¹,

Chen

Xin³

et al. 2008

Colloids and Surfaces B: Biointerfaces

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“…The entire system was kept at 37±0.5°C with continuous magnetic stirring at 100 rpm. At predetermined time intervals (1,2,3,4,5,6,8,10,12,24, and 48 h), aliquots of the release media were withdrawn and assayed spectrophotometrically at 254 nm. Withdrawn samples were replaced by fresh buffer.…”

Section: In Vitro Release Studymentioning

confidence: 99%

“…As far as we know, stealthy ACV PLGA NPs for IV administration have not yet been reported. However, self assembled lipid conjugate ACV NPs were prepared (6)(7)(8), but were cleared from the blood circulation very rapidly (90% within 5 min) after IV administration to rabbits. ACV loaded PLA nanospheres, with very low EE, for ophthalmic drug delivery were also prepared (9).…”

Section: Introductionmentioning

confidence: 99%

Preparation of Intravenous Stealthy Acyclovir Nanoparticles with Increased Mean Residence Time

et al. 2009

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Abstract. A major cause of thromboplebitis, during acyclovir (ACV) parenteral administration is the high pH of its reconstituted solution (pH 11). Its plasma half life is 2.5 h, requiring repeated administration which may result in excess of drug solubility leading to possible renal damage and acute renal failure. The present study reports the efficiency of stealthy ACV nanoparticles (NPs) to increase the mean residence time of the drug 29 times. It caused a marked decrease in thrombophlebitis when injected into rabbit's ear vein. The polymers used were (Poly lactic acid, polylactic-co-glycolic (PLGA) 85/15, PLGA 75/25, PLGA 50/50). Particles were evaluated for their encapsulation efficiency, morphology, particle size and size distribution, zeta potential, and in vitro drug release. Small NPs (280-300 nm) with 60% drug release after 48 h were obtained. Among the block copolymer used, poloxamer 407 was of superior coating properties with a coat thickness in the range of 1.5-8.3 nm and a decreased surface charge.

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Nanotechnology in Pharmaceutical Manufacturing

Jin

2010

Pharmaceutical Sciences Encyclopedia

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Langmuir monolayers of the long-chain alkyl derivatives of a nucleoside analogue and the formation of self-assembled nanoparticles

Cited by 24 publications

References 33 publications

Monolayers of the lipid derivatives of isoniazid at the air/water interface and the formation of self-assembled nanostructures in water

Monolayers of the lipid derivatives of isoniazid at the air/water interface and the formation of self-assembled nanostructures in water

Preparation of Intravenous Stealthy Acyclovir Nanoparticles with Increased Mean Residence Time

Nanotechnology in Pharmaceutical Manufacturing

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