Langwellig UV/Vis-anregbare, hocheffiziente und ultraschnelle Phototrigger für cAMP und cGMP

Hagen, Volker; Bendig, J.; Frings, Stephan; Eckardt, Torsten; Helm, S.; Reuter, D.; Kaupp, U. Benjamin

doi:10.1002/1521-3757(20010316)113:6<1077::aid-ange10770>3.0.co;2-7

Cited by 29 publications

(6 citation statements)

References 16 publications

(7 reference statements)

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“…The uncaging quantum yield of probe 1 was calculated to be 0.26 by means of HPLC analysis (see the Supporting Information), and was comparable to other 4‐methyl‐7‐ N , N ‐diethylaminocoumarin caged species 13b. The photolytic efficiency of caged probe 1 is 5538.…”

Section: Methodsmentioning

confidence: 87%

Chemical profiling of Portuguese Pinus pinea L. nuts

Evaristo¹,

Batista²,

Correia³

et al. 2010

J Sci Food Agric

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Section: Methodsmentioning

confidence: 87%

Chemical profiling of Portuguese Pinus pinea L. nuts

Evaristo¹,

Batista²,

Correia³

et al. 2010

J Sci Food Agric

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“…The syntheses of compounds 1 and 5 which contain the {7-[bis(carboxymethyl)amino]coumarin-4-yl}methoxycarbonyl (BCMACMOC) group, as well as the 2-(trimethylsilyl)ethyl ester analogue of 9 , which bears an α-carboxy-4,5-dimethoxy-2-nitrobenzyl (CDMNB) scaffold, were recently described. , [7,8-Bis(carboxymethoxy)coumarin-4-yl]methoxycarbonyl (7,8BCMCMOC) and α-carboxy-4-methoxy-2-nitrobenzyl (C4MNB) are novel photolabile protecting groups. The key synthon 6 was prepared by adapting the procedure for the synthesis of 6,7-bis(carboxymethoxy)-4-(hydroxymethyl)coumarin . Derivative 10 was synthesized from (4-methoxy-2-nitrophenyl)acetic acid analogous to 9 (for details see Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Wavelength-Selective Photoactivatable Protecting Groups for Thiols

et al. 2009

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We developed and characterized efficient, remarkably water-soluble photolabile protecting groups for thiols based on 2-nitrobenzyl and (coumarin-4-yl)methyl chromophores, among them two new ones. The protecting groups allow, due to their different absorption maxima, wavelength-selective photocleavage of binary mixtures of cysteine derivatives protected at the thiol function with various photolabile protecting groups by irradiation with light. The concept was also functional with the two different S-protected cysteine residues in derivatives of the model peptide resact. Selective photolysis could be achieved for the peptides Ac(0)-Cys(1)(BCMACMOC),Cys(8)(7,8BCMCMOC)-resact and Ac(0)-Cys(1)(C4MNB),Cys(8)(BCMACMOC)-resact by irradiation with light of > or = 402 nm or > or = 436 nm wavelength, respectively, followed by irradiation at lambda > or = 325 nm.

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“…Im Falle des membranpermeablen “caged”‐Phosphatidylinositol‐3‐phosphats [cgPI(3)P] wurde gezeigt, dass es nach “uncaging” sofort die Fusion früher Endosomen herbeiführte 8c. Hier präsentieren wir die Synthese eines membranpermeablen, photoaktivierbaren Derivats von PI(3,4,5)P 3 [cgPI(3,4,5)P 3 /AM ( 2 ), Schema ] mit der photoaktivierbaren 7‐Diethylamino‐4‐methylenhydroxycumarin‐Gruppe,11 die sich bereits im Falle des cgPI(3)P gut eignete. Wir zeigen Anwendungen in lebenden Zellen zur Induzierung von Zellmembrankräuseln und PH‐Domänen‐Translokation – als typischen Merkmalen der PI(3,4,5)P 3 ‐Signaltransduktion – in Gegenwart des PI‐3‐Kinase‐Inhibitors Wortmannin.…”

Section: Methodsunclassified