Lanthanide-doped upconversion nanoparticles electrostatically coupled with photosensitizers for near-infrared-triggered photodynamic therapy

Wang, Meng; Chen, Zhuo; Zheng, Wei; Zhu, Haomiao; Lu, Shan; Ma, En; Tu, Datao; Zhou, Shanyong; Huang, Mingdong; Chen, Xueyuan

doi:10.1039/c4nr01826e

Cited by 135 publications

(87 citation statements)

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“…UCNPs-based PDT agent for the inhibition of tumor growth both in vitro and in vivo due to high energy transfer efficiency [42]. Although LiREF 4 (RE = Y, Er-Lu) UCNPs have been widely reported, a systematic survey on the optical and magnetic properties of LiGdF 4 nanoparticles is still lacking because the syntheses of tetragonal-phase LiGdF 4 UCNPs via wet chemical method is challenging [31,43,44] and instead, orthorhombic-phase GdF 3 is apt to be formed (Fig.…”

Section: :Ybermentioning

confidence: 99%

“…material is an outstanding host matrix for both upconversion (UC) and down-conversion (DC) luminescence [38][39][40][41][42]. Mahalingam et al reported that their synthesized Yb and Tm codoped LiYF 4 UCNPs not only exhibit intense UC emission under excitation at 980 nm, but also generate additional emission lines in the deep-UV (294 nm) and near-infrared regions (1.46 µm), which can be used for anti-counterfeiting and telecommunication applications, respectively [38].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Growth of lanthanide-doped LiGdF4 nanoparticles induced by LiLuF4 core as tri-modal imaging bioprobes

et al. 2015

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Section: :Ybermentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Growth of lanthanide-doped LiGdF4 nanoparticles induced by LiLuF4 core as tri-modal imaging bioprobes

et al. 2015

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“…In view of this, Chen and Wang [105] attached β-carboxyphthalocyanine zinc (ZnPc(COOH), absorption peak at *676 nm) directly to ligand-free LiYF 4 :Yb/Er UCNPs in a very recent report. Owing to the removal of surface oleate ligands by acid treatment, positively charged Ln 3+ ions were exposed on the surface of UCNPs, which was confirmed by a positive zeta potential of +49.5 mV.…”

Section: Direct Conjugation Via Non-covalent Interactionsmentioning

confidence: 98%

Upconversion Nanoparticles for Light-Activated Therapy

Zhang¹

2014

Photon Upconversion Nanomaterials

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Light-activated therapy (LAT) has attracted enormous attention over the past decades because light enables noninvasive activation or release of various therapeutic compounds, such as photosensitizers, chemotherapeutic drugs, proteins, and genes with high spatial and temporal resolution. However, most currently used photosensitive compounds in LAT are sensitive to ultraviolet (UV) or visible light which suffers from some limitations such as low tissue penetration and photodamage to living organisms. Upconversion nanoparticles (UCNPs) that can convert near-infrared (NIR) light to visible/UV light have been proven to be effective for LAT in vivo in recent years, owing to the high tissue penetration and minimal photocytotoxicity of NIR light. Furthermore, hydrophilic UCNPs with targeting moieties can transport hydrophobic drugs in biological media and achieve active targeting, thus enhancing the therapeutic efficacy. In this chapter, we review the recent advances in the field of UCNP-based LAT with focus on photodynamic therapy (PDT) and NIR light-triggered release and uncaging.Keywords Light-activated therapy Á Upconversion nanoparticles Á Near-infrared excitation Á Photodynamic therapy Á Photosensitizer Á Light-triggered drug release Á Uncaging IntroductionThe past decades have seen considerable interest and progress in light-activated therapy (LAT), including photodynamic therapy (PDT), chemotherapy, gene therapy, and photothermal therapy (PTT) as light is noninvasive and controllable both spatially and temporally compared to other stimuli such as temperature, pH, ultrasound, and applied magnetic or electric fields [1,2]. Owing to these Zhenzhen Guo and Fan Zhang contributed together to this chapter.© Springer-Verlag Berlin Heidelberg 2015 F. Zhang, Photon Upconversion Nanomaterials, Nanostructure Science and Technology, DOI 10.1007/978-3-662-45597-5_9 285 advantages, this effective therapeutic approach is beneficial to control drug dosing in terms of quantity, location, and time, hence maximizing therapeutic effect while minimizing side effects [3]. However, the excitation of most commonly used photosensitizers for PDT and photoactive molecules for the release of chemotherapeutic drugs and genes relies on high-energy ultraviolet (UV) or visible light irradiation [4,5]. The tissue penetration depth of UV-visible light is shallow because of the scattering and absorption by tissue chromophores [6]. What is worse, the heterocyclic bases of DNA are major UV-absorbing chromophores in the skin. The absorption leads to damage of the DNA, which may result in the generation of tumors [7]. These limitations would greatly hamper their applications in vivo. Compared to UV and visible light, near-infrared (NIR) light has a larger penetration depth, lower levels of the auto-fluorescence , and photodamage effect [8] and is thus better suited for biomedical applications. Therefore, another component that is capable of converting NIR excitation into UV or visible emission should be introduced into current LAT systems in o...

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“…For example, based on a high‐temperature coprecipitation method, a series of AREF 4 (A = Li, Na, K; RE = Eu, Sm, Gd, Y, Lu, et al) NPs with different crystalline phases and particle sizes ranging from several to hundreds of nm were synthesized ( Figures 2 a–c) 15. Through a modified thermal decomposition method, ultrasmall (<5 nm) cubic LaOF, orthorhombic Lu 6 O 5 F 8 , and tetragonal YOF NPs were fabricated (Figures 2d–f) 16.…”

Section: General Protocols For the Fabrication Of Inorganic Lanthanidmentioning

confidence: 99%

Ultrasensitive Luminescent In Vitro Detection for Tumor Markers Based on Inorganic Lanthanide Nano‐Bioprobes

Zheng

Zhou

et al. 2016

Advanced Science

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Ultrasensitive and accurate detection of tumor markers is of vital importance for the screening or diagnosis of cancers at their early stages and for monitoring cancer relapse after surgical resection. Inorganic lanthanide (Ln3+) nanoparticles (NPs), owing to their superior physicochemical characteristics, are regarded as a new generation of luminescent nano‐bioprobes in the field of cancer diagnosis and therapy. In this progress report, a focus is set on our recent efforts on the development of inorganic Ln3+‐NPs as efficient luminescent nano‐bioprobes for the ultrasensitive in vitro biodetection of tumor markers, with an emphasis on the dissolution‐enhanced luminescent bioassay (DELBA), an emerging technique recently developed toward practical medical applications.

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Lanthanide-doped upconversion nanoparticles electrostatically coupled with photosensitizers for near-infrared-triggered photodynamic therapy

Cited by 135 publications

References 53 publications

Growth of lanthanide-doped LiGdF4 nanoparticles induced by LiLuF4 core as tri-modal imaging bioprobes

Growth of lanthanide-doped LiGdF4 nanoparticles induced by LiLuF4 core as tri-modal imaging bioprobes

Upconversion Nanoparticles for Light-Activated Therapy

Ultrasensitive Luminescent In Vitro Detection for Tumor Markers Based on Inorganic Lanthanide Nano‐Bioprobes

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