Laparoscopic liver resection for colorectal liver metastases: retrospective analysis of prognostic factors and oncological outcomes in a single-center cohort

Taillieu, Emily; Meyere, Céline De; Nuytens, Frederiek; Vanneste, Glenn; Libbrecht, Louis; Alaerts, H; Parmentier, Isabelle; Verslype, Chris; D’Hondt, Mathieu

doi:10.1007/s00423-022-02534-4

Cited by 4 publications

(6 citation statements)

References 57 publications

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“…*Clavien-Dindo morbidity classification. 18 †Post Hepatectomy Liver Failure, according to the ISGLS grading system. 19 IQR indicates interquartile range.…”

Section: Oncological Resultsmentioning

confidence: 99%

“…A robot-assisted minimally invasive approach for liver surgery was introduced in our center since April 2020. For our standardized approach of minimally invasive liver surgery, we refer to previously published papers 17–20…”

Section: Methodsmentioning

confidence: 99%

“…For our standardized approach of minimally invasive liver surgery, we refer to previously published papers. [17][18][19][20] Preoperative, perioperative, and postoperative data were collected from the prospectively kept database. Comorbidities were assessed with the Charlson Comorbidity Index.…”

Section: Methodsmentioning

confidence: 99%

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Combined Ablation and Resection for Colorectal Liver Metastases in the Minimally Invasive Surgical Era

Vandeputte¹,

Saveyn

Lutin

et al. 2023

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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Background: Thermal ablation is an accepted treatment modality for small and central liver tumors. In extensive colorectal liver metastatic disease (CRLM), hepatectomy can be combined with ablation, resulting in a parenchymal-sparing strategy. This may increase salvageability rates in case of recurrence.Methods: All patients with advanced CRLM that underwent combined ablation and resection between April 2012 and April 2021, were retrospectively analyzed from a prospectively maintained database. Primary endpoints include postoperative 30-day morbidity and ablation-site recurrence (ASR). The surgical approaches were compared. Ablated lesions were screened for ASR on postoperative follow-up imaging.Results: Of 54 patients that underwent combined ablation and resection, 32 (59.3%) were performed through a minimally invasive approach. Eleven (20.4%) were minor resections, 32 (59.3%) were technically major and 11 (20.4%) were anatomically major resections. Twelve complications occurred (22.2%), among which 2 (3.8%) major complications (Clavien-Dindo ≥ IIIa). Ninety-day mortality rate was 1.9%. Out of 82 ablated lesions, 6 ASRs (11.1%) occurred. Median blood loss was significantly lower in the minimally invasive group, compared with open [90 mL (32.5 to 200) vs. 200 mL (100 to 400), P = 0.005]. Pringle maneuver was significantly performed less in the minimally invasive group [8 (25.0%) vs. 16 (72.7%), P = 0.001], but took more time [36.1 min ( ± 15.6) vs. 21.6 ( ± 9.9); P = 0.011]. Short-term (1 y) overall and disease-free survival were respectively 81.4% and 50.0%. Conclusion:Combining microwave ablation and liver resection is a feasible and safe parenchymal-sparing technique, through both minimally invasive and open approach for treating extended CRLM disease. It has a low ablation-related complication rate and acceptable ablation-site recurrence rate.

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“…*Clavien-Dindo morbidity classification. 18 †Post Hepatectomy Liver Failure, according to the ISGLS grading system. 19 IQR indicates interquartile range.…”

Section: Oncological Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Combined Ablation and Resection for Colorectal Liver Metastases in the Minimally Invasive Surgical Era

Vandeputte¹,

Saveyn

Lutin

et al. 2023

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

Self Cite

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“…There is evidence that LLR for HCC and CRLM, as well as open hepatectomy (OH) for CRLM and hepatectomy for gastric cancer liver metastases (GCLM), can result in comparable or favorable long-term oncologic outcomes in terms of overall survival and disease-free survival. [22][23][24][25] In some studies, factors such as tumor characteristics, tumor growth pattern, tumor grade, and use of neoadjuvant chemotherapy were found to be associated with worse survival outcomes. 23,25 However, these findings may vary depending on the specific patient population and must be considered in a multidisciplinary treatment setting.…”

Section: Oncologic Outcomesmentioning

confidence: 99%

“…[22][23][24][25] In some studies, factors such as tumor characteristics, tumor growth pattern, tumor grade, and use of neoadjuvant chemotherapy were found to be associated with worse survival outcomes. 23,25 However, these findings may vary depending on the specific patient population and must be considered in a multidisciplinary treatment setting. 25…”

Section: Oncologic Outcomesmentioning

confidence: 99%

Factors influencing the selection of liver resection for adult patients with colorectal cancer liver metastases

Vespero,

Pacheco,

Cornejo

et al. 2023

Int Surg J

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The selection of liver resection surgery for adult patients with colorectal cancer liver metastases is a complex process influenced by various patient, tumor, and surgical factors. A systematic review was conducted with the PICO model research question, "are hepatectomy surgeries more effective than non-surgical treatment or alternative surgical treatments in improving survival and quality of life in adult patients?". A comprehensive scientific literature search was conducted using recognized medical and scientific databases. A narrative-question-answer synthesis was used to provide a comprehensive overview of the factors influencing the choice of hepatic recession surgery in adult patients with liver metastatic liver cancer. Concluding, the choice of liver surgery in adults with liver cancer metastasis depends on a wide range of factors such as the patient's age, characteristics of the tumor, peri and postoperative complications, and the number of metastases. Considering this is essential to the decision-making process and should be individualized for each patient.

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Textbook Outcomes and Quality of Life Assessment Following Liver Resection for Colorectal Metastasis

McGarry,

Quirke,

Neary

et al. 2024

Journal of Surgical Oncology

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BackgroundIt is unknown if textbook outcomes (TBOs) correlate with patient‐reported health‐related quality of life (HRQoL) parameters in patients undergoing hepatic resection for colorectal liver metastasises. Understanding this relationship is required to inform treatment decisions and optimise patient care. This single‐centre analysis aims to assess this correlation and provide insight into the impact of liver resection on patient well‐being in this population.MethodsSingle‐centre analysis of all liver resections performed for colorectal liver metastases (CRLM) at our centre from 2018 to 2023. The EuroQol‐5D (EQ‐5D) validated telephone questionnaire was used to assess HRQoL. The impact of a TBO on overall survival and recurrence‐free survival was investigated using Kaplan−Meier curve analysis. A Cox model was used to determine factors associated with improved survival.Results185 patients underwent liver resection for CRLM between 2018 and 2023. 55% of eligible patients completed the EQ‐5D telephone questionnaire. TBOs were achieved in 68.2% of CRLM at our institution. Achieving TBOs in this cohort was associated with improved HRQoL (p = 0.061).ConclusionThis study demonstrates excellent long‐term HRQoL in patients who undergo resection for CRLM. Achieving TBO in this cohort is associated with improved patient‐reported HRQoL. Our findings strengthen the utility of the previously defined textbook outcomes in CRLM.

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Laparoscopic liver resection for colorectal liver metastases: retrospective analysis of prognostic factors and oncological outcomes in a single-center cohort

Cited by 4 publications

References 57 publications

Combined Ablation and Resection for Colorectal Liver Metastases in the Minimally Invasive Surgical Era

Combined Ablation and Resection for Colorectal Liver Metastases in the Minimally Invasive Surgical Era

Factors influencing the selection of liver resection for adult patients with colorectal cancer liver metastases

Textbook Outcomes and Quality of Life Assessment Following Liver Resection for Colorectal Metastasis

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