Laparoscopic sleeve gastrectomy is safe and efficacious for pretransplant candidates

Lin, Matthew; Tavakol, Mehdi; Sarin, Ankit; Amirkiai, Shadee M.; Rogers, Stanley J.; Carter, Jonathan T.; Posselt, Andrew M.

doi:10.1016/j.soard.2013.02.013

Cited by 151 publications

(109 citation statements)

References 13 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…Takata et al 13 assessed 15 patients with severe liver disease (six of which were cirrhotic patients) treated with vertical sleeve gastrectomy and noted a 33% loss of excess weight after one year, with perioperative complications in two (13.3%) patients, both of whom were cirrhotic. In 26 transplant candidates submitted to vertical sleeve gastrectomy assessed by Lin et al, 14 perioperative complications were noted in 23.1%, with no mortality. The average loss of excess weight after one year was 50% and seven patients were submitted to transplant, without complications related to the bariatric surgery.…”

Section: Resultsmentioning

confidence: 94%

Bariatric surgery in individuals with liver cirrhosis: A narrative review

Cazzo

Gestic

Chaim

et al. 2017

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

Summary Introduction: Bariatric surgery has become the gold standard treatment for morbid obesity, but there is no consensus regarding its safety and efficacy among individuals with chronic liver diseases. Objective: To critically evaluate the existing evidence on literature about bariatric surgery in individuals with liver cirrhosis. Method: Narrative review performed by means of an online search in the MEDLINE and LILACS databases. Results: Bariatric surgery is safe and effective in individuals with chronic liver disease without clinical decompensation or significant portal hypertension. Individuals with severe liver function impairment present significantly higher surgical morbidity and mortality. Among candidates to liver transplantation, surgery may be performed before, after and even during transplantation, and there is a predominant trend to perform it after. Vertical sleeve gastrectomy seems to be the most adequate technique in this group of subjects. Conclusion: Bariatric surgery is safe and effective in individuals with compensated cirrhosis without significant portal hypertension, but presents higher morbidity. Among candidates to liver transplantation and/or individuals with severe portal hypertension, morbidity and mortality are significantly higher.

show abstract

Section: Resultsmentioning

confidence: 94%

Bariatric surgery in individuals with liver cirrhosis: A narrative review

Cazzo

Gestic

Chaim

et al. 2017

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

show abstract

“…The safety of this surgery in our group was matched with that reported in many other studies. 26,[32][33][34] In a larger series from 2013 involving laparoscopic sleeve gastrectomy in patients awaiting solid-organ transplant, Lin and associates 35 reported that laparoscopic sleeve gastrectomy is well-tolerated, technically feasible, and improves candidacy for transplant.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Gheith

Al-Otaibi

Halim³

et al. 2017

Exp Clin Transplant

View full text Add to dashboard Cite

Objectives: The idea of transplanting organs is not new, nor is the disease of obesity. Obese transplant recipients have greater risk of early death than their cohorts, which is not due to increased rejection but due to obesity-related complications, including arterial hypertension, diabetes, and delayed graft function. Here, our aim was to evaluate the effects of bariatric surgery versus lifestyle changes on outcomes of moderate to severely obese renal transplant recipients. Materials and Methods: Twenty-two morbidly obese patients with stable graft function who underwent bariatric surgery were compared with 44 obese patients on lifestyle management (control group). Both groups were evaluated regarding graft and patient outcomes. Results: The studied groups were comparable demographically. In the bariatric study group versus control group, we observed that the mean body mass index was 38.49 ± 9.1 versus 44.24 ± 6 (P = .024) at transplant and 34.34 ± 7.6 versus 44.38 ± 6.7 (P = .002) at 6 months of bariatric surgery. Both groups received a more potent induction immunosuppression, but this was significantly higher in the obese nonbariatric control group (P < .05). There were more patients with slow and delayed graft functions in the same nonbariatric group. The 2 groups were comparable regarding new-onset diabetes after transplant, total patients with diabetes, and graft outcomes (P > .05). Conclusions: Bariatric surgeries are feasible, safe procedures for selected obese renal transplant recipients.

show abstract

“…Potential benefits not only range from pre-transplant listing to better postoperative outcomes, but also to long term graft function and survival potentially from reducing risk of recurrent NAFLD and cardiovascular events. BS has been successfully used before, during, and after liver transplantation for NAFLD, though relatively few studies exist, most published as case series ranging up to 20 patients [18,19] . There remains a lack of consensus regarding the acceptable degrees of liver dysfunction or portal hypertension that will permit successful bariatric surgery in the pre-transplant/cirrhotic setting.…”

Section: Research Highlightmentioning

confidence: 99%

“…At this time, randomized controlled trials addressing the type and timing of BS in relation to liver transplantation have not been conducted, and given the overall paucity of data regarding this endeavor for these patients, firm recommendations regarding these considerations cannot be made. Nevertheless, the potential role for BS in obese NAFLD cirrhotic patients is promising, and several independent authors and institutions have reported successful outcomes demonstrating safety and efficacy in producing sustained weight-loss [19][20][21][22][23][24][25][26][27] . NAFLD is projected in the near future to become the leading etiology of liver transplantation in the United States.…”

Section: Research Highlightmentioning

confidence: 99%

Liver Transplantation for Nonalcoholic Fatty Liver Disease: Role of Bariatric Surgery for Comorbid Obesity

Patel

2016

J Adv Nutr Hum Metab

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent form of chronic liver disease throughout the world and is associated with substantial morbidity and mortality related to liver disease and the consequences of metabolic syndrome. NAFLD is projected to become the leading indication for liver transplantation in the United States in the near future, and presents unique challenges due to common comorbidities, particularly obesity. As obesity is often a barrier to transplant, distinctive decision-making and care is needed for this growing population. Bariatric surgery offers a promising option for liver transplant specialists to consider in obese patients with NAFLD cirrhosis. This research highlight reviews the rising burden of NAFLD, concerns regarding obesity and liver transplant, and the potential role of bariatric surgery in the liver transplantation paradigm.Keywords: NAFLD; Cirrhosis; Obesity; Liver Transplantation; Bariatric Surgery To cite this article: Yuval A. Patel, et al. Liver transplantation for nonalcoholic fatty liver disease: role of bariatric surgery for comorbid obesity.

show abstract

Laparoscopic sleeve gastrectomy is safe and efficacious for pretransplant candidates

Cited by 151 publications

References 13 publications

Bariatric surgery in individuals with liver cirrhosis: A narrative review

Bariatric surgery in individuals with liver cirrhosis: A narrative review

Untitled

Liver Transplantation for Nonalcoholic Fatty Liver Disease: Role of Bariatric Surgery for Comorbid Obesity

Contact Info

Product

Resources

About