Laparoscopic Sphincter Augmentation Device Eliminates Reflux Symptoms and Normalizes Esophageal Acid Exposure

Bonavina, Luigi; DeMeester, Tom R.; Fockens, Paul; Dunn, Daniel H.; Saino, Greta; Bona, Davide; Lipham, John C.; Bemelman, Willem A.; Ganz, Robert A.

doi:10.1097/sla.0b013e3181fd879b

Cited by 166 publications

(103 citation statements)

References 16 publications

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“…This rate of persistent dysphagia is similar to that observed in the pilot study and in registries in the United States and Europe. 10,11 Removal of the device was required in six patients within 21 days to 2.9 years after placement. The possibility of easy removal of the device after a longer interval is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…The device involves the use of magnetic attraction through adjacent magnetic beads, which augments the resistance of the esophageal sphincter to abnormal opening associated with reflux. [9][10][11] Each bead contains a sealed core of magnetic neodymium iron boride that produces a precise and permanent force of attraction. The beads are connected to adjacent beads by small wires that allow the device to expand.…”

Section: Study Proceduresmentioning

confidence: 99%

“…The feasibility of this concept was shown in a pilot study. 11 We report the 3-year outcomes of a 5-year clinical trial assessing the safety and effectiveness of a magnetic device for sphincter augmentation.…”

mentioning

confidence: 99%

“…7,8 Augmentation of the esophageal sphincter with a magnetic device may provide an alternative treatment for patients who have incomplete symptom relief with proton-pump inhibitors or who are reluctant to undergo surgical fundoplication. [9][10][11] The aim of magnetic sphincter augmentation is to improve the barrier function of the sphincter without altering the hiatal and gastric anatomy or interfering with swallowing, belching, or vomiting. The feasibility of this concept was shown in a pilot study.…”

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confidence: 99%

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Esophageal Sphincter Device for Gastroesophageal Reflux Disease

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Section: Discussionmentioning

confidence: 99%

Section: Study Proceduresmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Esophageal Sphincter Device for Gastroesophageal Reflux Disease

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“…There have also been two other large studies demonstrating excellent results with the LINX device (85 % success rate) [11,12].…”

Section: The Linx Reflux Management System (Torax Medical)mentioning

confidence: 99%

Gastroesophageal Reflux Disease: Diagnosis and Patient Selection

Singhal

Khaitan

2014

Indian J Surg

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Gastroesophageal reflux disease (GERD) has a high prevalence worldwide. Recent reports have noted a high prevalence even in Asian countries. GERD significantly affects the quality of life and can present with a wide variety of symptoms. Not all reflux is acid, and non-acid reflux disease can be more difficult to diagnose and can lead to a variety of extra-esophageal symptoms. Although proton pump inhibitors (PPIs) are effective in the majority of patients, but they are not without side effects, and their effect often diminishes with time. For patients who do not desire to be on long-term PPIs or have incomplete symptom resolution with medication, various endoscopic and minimally invasive treatment modalities are now available. The etiology of GERD can be multifactorial including dysfunctional LES, presence of a hiatal hernia, and transient lower esophageal sphincter relaxations (TLESRs). We hence believe that the treatment should be individualized to the cause of the reflux. In the following review, we describe the etiology of reflux disease and attempt to lay a framework for the diagnosis and selection of patients for the various interventions available for treatment, along with their evidence base.

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