Laparoscopic Surgical Glue Injection Hernioplasty: A Single-Institution Experience

Park, Si Min; Shukri, Nasser; Chang, Eun Young; Ho, In; Han, Seok Joo

doi:10.1089/lap.2015.0521

Cited by 4 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fresh porcine skin was used as adherend in the adhesion strength test, due to its biological similarity to human dermis and commonly used for biomedical experiments. ,− The results of adhesion strength and the typical adhesion test setup are demonstrated in Figure A. The strong commercial cyanoacrylate adhesive, which is widely used, was used as a contrast. − Among the citrate-based polyester tissue adhesive we prepared, POC-d (free of PEO) behaved best and showed more than half the average adhesion strength of the strongest commercial adhesive, cyanoacrylate. With the introduce of hydrophilic segment from PEO, the adhesion strength decreased.…”

Section: Resultsmentioning

confidence: 99%

Hydrophobic and Hydrophilic Effects in a Mussel-Inspired Citrate-Based Adhesive

2020

Langmuir

View full text Add to dashboard Cite

The citrate-based tissue adhesive, synthesized by citric acid, diol, and dopamine, is a kind of mussel-inspired adhesive. The adhesion of mussel-inspired adhesive is not completely dependent on 3, 4-dihydroxyphenylalanine (Dopa) groups. The backbone structure of the adhesive also greatly affects the adhesion. In this study, to explore the effects of hydrophobicity and hydrophilicity of the backbone structure on adhesion, we prepared a series of citrate-based tissue adhesives (POEC-d) by changing the molar ratio of two diols, 1, 8-octanediol (O) and poly(ethylene oxide) (E), which formed hydrophobic segment units and hydrophilic segment units, respectively, in the molecule structure. The properties of cured adhesives showed that the adhesive with high E units had high swelling, rapid degradation, and low cohesion. In the adhesion strength measurement on the porcine skin, the adhesive with higher hydrophobicity was more likely to perform better. For the interfacial adhesion, hydrophilicity was conducive to the diffusion and penetration on the skin surface, but hydrophobic interaction showed a stronger effect to adhere with skin and hydrophobic association increased the adhesive concentration on the interface; for the bulk cohesion, hydrophobicity led to coacervation, promoting the Dopa-quinone coupling for cross-linking. In this amphipathic, citrate-based, soft-tissue adhesive system, when the feed ratio of hydrophilic segment was lower than 0.7, the coacervation could be formed through hydrophobic interaction, forming an efficient underwater adhesion system similar to that of mussels.

show abstract

Section: Resultsmentioning

confidence: 99%

Hydrophobic and Hydrophilic Effects in a Mussel-Inspired Citrate-Based Adhesive

2020

Langmuir

View full text Add to dashboard Cite

show abstract

“…6 Despite these concerns, Park et al reported very promising results with laparoscopic surgical glue injection hernioplasty in children. 18,19 Their method required only one working port and one camera port and b-CNA glue was adopted to close the defect after the mesothelial layer surrounding the internal inguinal ring was electrically cauterized. The main limitation of this study was that it did not include male patients to avoid potential damage to the vas deferens.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic Injection of Tissue Adhesives for Inguinal Hernia Repair in a Rabbit Model: Results of an Experimental Comparative Study with the Standard Laparoscopic Inguinal Hernia Repair

Escolino

Esposito

Eaton

et al. 2020

Journal of Laparoendoscopic & Advanced Surgical Techniques

View full text Add to dashboard Cite

Background: The injection of tissue adhesives has been proposed as an alternative to standard laparoscopic inguinal hernia repair but no evidence is available in the pediatric population. This study aimed to evaluate safety, efficacy, and feasibility of injection of tissue adhesives for inguinal hernia repair in a rabbit model. Materials and Methods: Thirty-six New Zealand White male rabbits underwent laparoscopic inguinal hernia repair. In each animal, the hernia defect was repaired using glue on the right side and purse-string suture on the left side. The animals were divided in 3 groups, each 1 of 12 animals, according to the glue used: Glubran 2 (cyanoacrylate), Histoacryl (cyanoacrylate), and BioGlue (bovine serum albumin-based). For each group, 6 animals were sacrificed at 7 days postoperatively, and 6 animals at 90 days postoperatively. Histopathological exam of testis and spermatic bundle was performed. Results: The hernia defect was successfully closed on both sides in all cases. The injection of glue was faster than suture repair (P = .001). Postoperative complications (epiploonparietal adhesions, spermatic vessel ectasia, and hydrocele) rate was significantly higher on the right side compared to the left side at both short-and longterm follow-up (P = .001). Furthermore, a lower maturity of testicles treated by adhesive compared with suture was histologically demonstrated at both short-and long-term follow-up (P = .001). Conclusions: The present experimental study confirmed the feasibility and efficacy of inguinal hernia repair by injection of tissue adhesive. However, several critical issues emerged about the safety of this technique. The use of glue was associated with higher incidence of postoperative complications and significant decrease of testicular maturity compared with standard suture repair. Based upon these preliminary results, repair using suture remains the standard of care for inguinal hernia in children. Further experimental studies are needed to assess the safety of injection of tissue adhesives for pediatric inguinal hernia repair.

show abstract

“…We adopted the previously published techniques of LGH [25] and LSH [8]. All procedures were performed while the patients were under general anesthesia.…”

Section: Surgical Techniquesmentioning

confidence: 99%

“…Previously, the effectiveness and safety of laparoscopic glue hernioplasty (LGH) were evaluated in a series of animal studies [18,23,24]. Here, we report our single-institution experience, which provides evidence that the LGH technique is effective in treating inguinal hernia in pediatric female patients [25]. However, so far, there are no reports on how LGH results compare to conventional laparoscopic suture hernioplasty (LSH).…”

Section: Introductionmentioning

confidence: 97%

Comparison of Surgical Outcomes of Laparoscopic Glue and Laparoscopic Suture Hernioplasty in Pediatric Female Inguinal Hernia

Ihn

Jeon

et al. 2022

Children

Self Cite

View full text Add to dashboard Cite

This study aimed to report the surgical outcomes of laparoscopic glue hernioplasty (LGH) compared with conventional laparoscopic suture hernioplasty (LSH) in pediatric female inguinal hernia repair. We retrospectively analyzed 465 female pediatric patients who underwent laparoscopic inguinal hernia repair between January 2013 and December 2020. LGH and LSH were performed in 95 and 370 cases, respectively. Surgical outcomes (length of hospital stay, operative time, complications, and recurrences) were compared between the LGH and LSH groups. We found that the operation times for bilateral hernia repair were shorter in the LGH group (LGH: 35.5 ± 8.2 min, LSH: 45.2 ± 11.6 min; p < 0.001). No significant differences in complications or recurrences were observed between the two groups during the follow-up period. Our findings suggest that LGH is a feasible and easily applied surgical technique for the treatment of pediatric female inguinal hernia.

show abstract

Laparoscopic Surgical Glue Injection Hernioplasty: A Single-Institution Experience

Cited by 4 publications

References 27 publications

Hydrophobic and Hydrophilic Effects in a Mussel-Inspired Citrate-Based Adhesive

Hydrophobic and Hydrophilic Effects in a Mussel-Inspired Citrate-Based Adhesive

Laparoscopic Injection of Tissue Adhesives for Inguinal Hernia Repair in a Rabbit Model: Results of an Experimental Comparative Study with the Standard Laparoscopic Inguinal Hernia Repair

Comparison of Surgical Outcomes of Laparoscopic Glue and Laparoscopic Suture Hernioplasty in Pediatric Female Inguinal Hernia

Contact Info

Product

Resources

About