Laparoscopic Visualization and Dissection of Retroperitoneal Lymph Nodes after Patent Blue Dye Injection: A Pilot Study

Irkılata, Hasan Cem; Başal, Şeref; Yıldırım, İbrahim; Kurt, Bülent; Aydur, Emin; Zor, Murat; Göktaş, Serdar

doi:10.1089/end.2007.0278

Cited by 2 publications

(1 citation statement)

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“…That said, our study was intended simply as a preliminary experimental investigation before undertaking direct prospective comparison of techniques in human patients. In this regard, our reported experimental model is similar to other published investigational studies, which have also used a porcine model, 15,[27][28][29] often with successful transition thereafter to human studies. 27,29 Indeed, investigation of the efficacy and long-term outcomes of L-RPLND in humans at our institution is currently underway, 6 although reports of long-term prospective comparison of lymph node yields between the open and laparoscopic approaches in humans is currently lacking.…”

Section: Benway Et Alsupporting

confidence: 81%

Open Versus Laparoscopic Retroperitoneal Lymph Node Dissection: Assessing Adequacy of Dissection in a Porcine Model

Benway

Diaz²,

Katz³

et al. 2009

Journal of Endourology

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Background and Purpose: Laparoscopic retroperitoneal lymph node dissection (L-RPLND) is emerging as a viable alternative to traditional open retroperitoneal lymph node dissection (O-RPLND). Despite numerous reports confirming clinical oncologic equivalency between the two approaches, however, concerns still remain over the adequacy of laparoscopic dissection. We therefore sought to compare the completeness of dissection between O-RPLND and L-RPLND in a porcine model. Materials and Methods: Fourteen domestic swine were divided into two equivalent groups. Both groups underwent bilateral retroperitoneal lymph node dissection, approximating templates used in human dissection. In one group, the procedure was performed through an open midline incision, while the other group underwent completely laparoscopic dissection. Tissue was independently analyzed by a pathologist, who recorded lymph node yield based on microscopic evaluation. Results: All animals in the L-RPLND group underwent successful procedures, without the need for conversion. Two open procedures were aborted because of hemorrhage. Mean lymph node yield from O-RPLND was 32, while the mean yield for L-RPLND was 29. This difference was not statistically significant (P ¼ 0.65). Conclusions: In the porcine model, L-RPLND is capable of providing a quality of dissection equivalent to that of O-RPLND, in terms of absolute lymph node yield on microscopic examination. The applicability of this data to human patients, however, may be limited by significant anatomic differences between the human and the pig. Further prospective comparison in human patients is critically needed.

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Section: Benway Et Alsupporting

confidence: 81%

Open Versus Laparoscopic Retroperitoneal Lymph Node Dissection: Assessing Adequacy of Dissection in a Porcine Model

Benway

Diaz²,

Katz³

et al. 2009

Journal of Endourology

View full text Add to dashboard Cite

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Retroperitoneal Lymph Node Mapping with Patent Blue Dye Injection: Is the Testicular Route Feasible?

Zor¹,

Yıldırım²

2012

Arch Clin Exp Surg

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Laparoscopic Visualization and Dissection of Retroperitoneal Lymph Nodes after Patent Blue Dye Injection: A Pilot Study

Abstract: We demonstrated that spermatic funicular injection of PVB dye is an effective and accurate method for retroperitoneal lymph node visualization in pigs. The use of this technique in combination with a laparoscopic approach makes RPLND easier and more effective.

Cited by 2 publications

References 15 publications

Open Versus Laparoscopic Retroperitoneal Lymph Node Dissection: Assessing Adequacy of Dissection in a Porcine Model

Open Versus Laparoscopic Retroperitoneal Lymph Node Dissection: Assessing Adequacy of Dissection in a Porcine Model

Retroperitoneal Lymph Node Mapping with Patent Blue Dye Injection: Is the Testicular Route Feasible?

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