This paper represents the processing of the two-dimensional Laplace transform with the two-dimensional Marichev–Saigo–Maeda integral operators and two-dimensional incomplete hypergeometric function. This article provides an entirely new perspective on the Marichev–Saigo–Maeda operators and incomplete functions. In addition, we have included some interesting results, such as left-sided Saigo–Maeda operators and right-sided Saigo–Maeda operators, making this a good direction for symmetry analysis.