Laponite intercalated biomimetic multilayer coating prevents glucocorticoids induced orthopedic implant failure

A sustained-release PDGF-BB nanocomposite hydrogel for DM-associated bone regeneration

“…In addition, the direct addition of LAPONITE® to the culture medium has been shown to induce osteogenic differentiation in the presence of glucocorticoids with no biological toxicity below 100 μg mL −1 . 25 Based on the previous CCK8, we selected a concentration of 1% for follow-up studies, and the above results suggest that osteogenic differentiation may be induced under high glucose stimulation.…”

Strategies to improve the performance of polyetheretherketone (PEEK) as orthopedic implants: from surface modification to addition of bioactive materials

“…In addition to its direct bone-enabling effects, hyaluronic acid can also be used for drug delivery. Liu et al 136 doped LAPONITE s , which can be used to attenuate glucocorticoid-induced implant loosening, into a deposition system consisting of hyaluronic acid and chitosan, which was subsequently encapsulated on a PEEK surface to help prevent implant failure in glucocorticoidtreated patients. Zheng et al 137 chemically bonded PEEK with another natural glycosaminoglycan (chondroitin sulfate) by using ethylenediamine as an intercalating reactant.…”

Latest advances: Improving the anti-inflammatory and immunomodulatory properties of PEEK materials

“…The retention of PEEK coating is an essential factor in choosing the coating technique and material. LBL coating was largely retained during in vitro simulated surgical implantation, and the surface roughness caused by nanopores during the preparation of LBL coating also affected the adhesion strength of the LBL coating [ 151 , 161 ].…”