Laponite® gel formulation containing simvastatin for melanoma treatment

Suterio, Natalia; Bazzo, Giovana Carolina; Rauber, Gabriela Schneider; Silva, Adny Henrique; Caon, Thiago; Parize, Alexandre Luís; Creczynski-Pasa, Tânia Beatriz; Stulzer, Hellen Karine

doi:10.1016/j.clay.2022.106651

Cited by 5 publications

(4 citation statements)

References 57 publications

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“…This internalization was also suggested after OCT visualization [ 28 ]. In addition, an antimelanoma Laponite gel formulation containing simvastatin [ 102 ], a physical crosslinking of magnetic Laponite nanoparticles with 5-fluorouracil [ 103 ]— and methotrexate, which is also used for inflammatory pathologies affecting the eye [ 104 ], exhibited antitumoral activity. Finally, benzoyl peroxide generated and sustainedly released oxygen, which chemically modified the tumor microenvironment and reversed the effects of hypoxia.…”

Section: Resultsmentioning

confidence: 99%

Laponite for biomedical applications: An ophthalmological perspective

Rodrigo,

Cardiel,

Fraile

et al. 2024

Materials Today Bio

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Section: Resultsmentioning

confidence: 99%

Laponite for biomedical applications: An ophthalmological perspective

Rodrigo,

Cardiel,

Fraile

et al. 2024

Materials Today Bio

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“…The improvement of these systems led to an increase in the effectiveness and safety of the drug by adjusting the time, location, and rate at which the therapeutic compound is released. LAP turned out to be an excellent candidate as a drug delivery carrier due to its aluminosilicate layered structure, which is able to incorporate different drugs (e.g., itraconazol [ 86 ], donepezil [ 87 ], ciprofloxacin [ 88 ], dexamethasone [ 89 ], microbial peptides [ 90 ], and simvastatin [ 91 , 92 ]) and control their release by ion exchange while also protecting and stabilizing fragile drugs or biomolecules.…”

Section: Laponite ® Applicationsmentioning

confidence: 99%

“…This formulated hydrogel demonstrates efficiency as a drug delivery vehicle for small molecules as an alternative to growth factors for stem cells (for example, simvastatin) or to promote bone tissue regeneration. Considering the antibacterial effects of simvastatin, the higher affinity for the epidermis than for the dermis [ 96 , 97 ], and the results obtained in the treatment of skin infections associated with melanoma [ 98 , 99 ], Suterio et al [ 92 ] have prepared LAP-based gels containing lipophilic simvastatin, different LAP concentrations, and two skin permeation enhancers, namely isopropyl myristate (MYR) and squalene (SQ). The interaction of the drug and the permeation enhancer with the charged surfaces of the LAP in the hydroalcoholic medium leads to the formation of tactoids (ordered layered structures) with an impact on drug release.…”

Section: Laponite ® Applicationsmentioning

confidence: 99%

Laponite®—From Dispersion to Gel—Structure, Properties, and Applications

Brunchi,

Morariu

2024

Molecules

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Laponite® (LAP) is an intensively studied synthetic clay due to the versatility given by its layered structure, which makes it usable in various applications. This review describes the multifaceted properties and applications of LAP in aqueous dispersions and gel systems. The first sections of the review discuss the LAP structure and the interactions between clay discs in an aqueous medium under different conditions (such as ionic strength, pH, temperature, and the addition of polymers) in order to understand the function of clay in tailoring the properties of the designed material. Additionally, the review explores the aging phenomenon characteristic of LAP aqueous dispersions as well as the development of shake-gels by incorporating LAP. The second part shows the most recent studies on materials containing LAP with possible applicability in the drilling industry, cosmetics or care products industry, and biomedical fields. By elucidating the remarkable versatility and ease of integration of LAP into various matrices, this review underscores its significance as a key ingredient for the creation of next-generation materials with tailored functionalities.

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“…It is obvious from the above data that the effect of polyP on the colloidal stability of LRD must be unambiguously understood when such colloids are designed. This requires the knowledge of the intricate relationship between the surface chemistry and aggregation of LRD particles in polyP solutions to utilize these systems in various areas, including tissue engineering, , biomedicines, , drug delivery, composite materials, biosensors, and the cosmetic industry . Nevertheless, there is a lack of comprehensive quantitative data on the surface charge and aggregation rate of LRD particles in the presence of polyP.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Polyphosphates on the Colloidal Stability of Laponite Particles

Katana,

Baptista,

Schneider

et al. 2024

J. Phys. Chem. B

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The effect of polyphosphate (polyP) adsorption on the colloidal properties of disc-shaped laponite (LRD) particles was examined in aqueous dispersions with a focus on elucidating the interparticle forces that govern the colloidal stability of the systems. The charge and aggregation rate data of bare LRD exhibited an ionic strength-dependent trend, confirming the presence of double-layer repulsion and van der Waals attraction as major surface interactions. The charge of LRD particles significantly increased in magnitude at elevated polyP concentrations as a result of polyP adsorption and subsequent overcharging of the positively charged sites on the edges of the LRD discs. A transition from stable to unstable LRD colloids was observed with increasing polyP doses indicating the formation of aggregates in the latter systems due to depletion forces and/or bridging interactions induced by dissolved or adsorbed polyP, respectively. The degree of phosphate polymerization influenced neither the charge nor the aggregation mechanism. The findings clearly confirm that polyP adsorption was the driving phenomenon to induce particle aggregation in contrast to other clay types, where phosphate derivatives act as dispersion stabilizing agents. This study provides valuable insights into the early stages of aggregation in colloidal systems involving LRD and polyPs, which have a crucial role in predicting further material properties that are important to designing LRD-polyP composites for applications such as potential phosphate sources in chemical fertilizers.

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Laponite® gel formulation containing simvastatin for melanoma treatment

Cited by 5 publications

References 57 publications

Laponite for biomedical applications: An ophthalmological perspective

Laponite for biomedical applications: An ophthalmological perspective

Laponite®—From Dispersion to Gel—Structure, Properties, and Applications

The Impact of Polyphosphates on the Colloidal Stability of Laponite Particles

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