Large artery stiffness predicts ischemic threshold in patients with coronary artery disease

Kingwell, Bronwyn A.; Waddell, Tamara K.; Medley, Tanya L; Cameron, James D.; Dart, Anthony M.

doi:10.1016/s0735-1097(02)02009-0

Cited by 238 publications

(157 citation statements)

References 25 publications

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“…As the aorta stiffens with aging, pulse pressure increases and diastolic pressure decreases. The decrease in diastolic blood pressure then compromises the coronary circulation and furthermore contributes to ischemic heart disease and cardiovascular events [64,65]. As CML within the arterial extracellular matrix was not measured, it is not possible to establish whether this mechanism contributed to aortic stiffening via crosslinking.…”

Section: Discussionmentioning

confidence: 99%

Plasma advanced glycation end products (AGEs) and NF-κB activity are independent determinants of diastolic and pulse pressure

Sourris

Lyons

Dougherty

et al. 2014

Clinical Chemistry and Laboratory Medicine

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Background: High levels of circulating advanced glycation end products (AGEs) can initiate chronic low-grade activation of the immune system (CLAIS) with each of these factors independently associated with cardiovascular (CV) morbidity and mortality. Therefore, our objective was to characterize the relationship between serum AGEs, CLAIS and other risk factors for CV disease in normotensive non-diabetic individuals. Methods: We measured body mass index (BMI), waistto-hip ratio (WHR), blood pressure, lipid and glucose profile in 44 non-diabetic volunteers (17 female, 27 males). Carbo xymethyl-lysine (CML) was measured by ELISA as a marker for circulating AGEs and NF-κB p65 activity as an inflammatory marker by DNA-binding in peripheral blood mononuclear cells lysates (PBMC). Results: Plasma CML concentrations were related to diastolic blood pressure (r = −0.51, p < 0.01) independently of age, sex, BMI and WHR (p < 0.05). Diastolic blood pressure was also related to NF-κB activity in PBMC (r = 0.47, p < 0.01) before and after adjustment for age, sex, BMI and WHR (p < 0.05). Plasma CML concentrations were related to the pulse pressure before (r = 0.42; p < 0.05) and after adjustment for age, sex, BMI and waist (p < 0.05). Neither CML nor NF-κB activity were related to systolic blood pressure (both p = ns). Plasma CML concentrations were not associated with plasma lipid or glucose concentrations (all p = ns). Conclusions: Plasma AGE levels and NF-κB activity in PBMC were independent determinants of diastolic and pulse pressure in healthy normotensive individuals. This association suggests a role for AGEs in the etiology of hypertension, possibly via the initiation of CLAIS and aortic stiffening.

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Section: Discussionmentioning

confidence: 99%

Plasma advanced glycation end products (AGEs) and NF-κB activity are independent determinants of diastolic and pulse pressure

Sourris

Lyons

Dougherty

et al. 2014

Clinical Chemistry and Laboratory Medicine

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“…58,59 If untreated, these interdependent conditions progress and establish a cyclical relationship that results in further kidney and vascular damage. Subsequent remodeling and sclerosis of the vessels can compromise the perfusion reserve and increase the risk for ischemic events, 60 which are a common trigger for the initiation of arrhythmias. In the setting of ESRD, vascular remodeling is even more pronounced because calciumphosphate deposition may further exacerbate vascular integrity.…”

Section: Possible Mechanismsmentioning

confidence: 99%

CKD and Sudden Cardiac Death

Whitman¹,

Feldman

Deo

2012

Journal of the American Society of Nephrology

118

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Multiple studies demonstrate a strong independent association between CKD and cardiovascular events including death, heart failure, and myocardial infarction. This review focuses on recent clinical studies that expand this spectrum of adverse cardiovascular events to include ventricular arrhythmias and sudden cardiac death. In addition, experimental models suggest structural remodeling of the heart and electrophysiologic changes in this population. These processes may explain the increased arrhythmic risk in kidney disease and aid in identifying patients who are at higher risk for sudden cardiac death. Finally, we review here the data to support the use of pharmacologic and device-based therapies for both the primary and secondary prevention of sudden cardiac death.

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“…Studies have correlated the arterial compliance with the stroke risk (Kingwell et al 2002). Computer Methods in Biomechanics and Biomedical Engineering, 2011, 14(12), [1][2][3][4][5][6][7][8][9][10] The originality of this study is to numerically investigate the identifiability of the heterogeneities elastic parameters from simulated PC-MRI data (Draney et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Identification of heterogeneous elastic properties in stenosed arteries: a numerical plane strain study

Franquet

Avril

Riche

et al. 2012

Computer Methods in Biomechanics and Biomedical Engineering

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Assessing the vulnerability of atherosclerotic plaques requires an accurate knowledge of the mechanical properties of the plaque constituents. It is possible to measure displacements in vivo inside a plaque using magnetic resonance imaging. An important issue is to solve the inverse problem that consists in estimating the elastic properties inside the plaque from measured displacements. This study focuses on the identifiability of elastic parameters e.g. on the compromise between identification time and identification accuracy. An idealised plane strain Finite Element (FE) model is used. The effects of the FE mesh, of the a priori assumptions about the constituents, of the measurement resolution and of the data noise are numerically investigated.

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Large artery stiffness predicts ischemic threshold in patients with coronary artery disease

Abstract: Within a patient group with moderate CAD, large artery stiffness was a major determinant of myocardial ischemic threshold.

Cited by 238 publications

References 25 publications

Plasma advanced glycation end products (AGEs) and NF-κB activity are independent determinants of diastolic and pulse pressure

Plasma advanced glycation end products (AGEs) and NF-κB activity are independent determinants of diastolic and pulse pressure

CKD and Sudden Cardiac Death

Identification of heterogeneous elastic properties in stenosed arteries: a numerical plane strain study

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