Large B-cell lymphoma of the base of the tongue and oral cavity: a practical approach to identifying prognostically important subtypes

Owosho, Adepitan A.; Bilodeau, Elizabeth A.; Surti, Urvashi; Craig, Fiona E.

doi:10.1016/j.oooo.2014.06.002

Cited by 17 publications

(20 citation statements)

References 41 publications

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“…Four out of five of the DLBCL cases were NOS subtypes. This is consistent with the findings from 17 DLBCL cases reported by Owosho AA et al [27]; of the 17 cases, 16 cases were located at the base of tongue and 14 cases were DLBCL, NOS. Cases of DLBCL, NOS were further divided based on immunohistochemistry into two subtypes, GC and NGC.…”

Section: Discussionsupporting

confidence: 92%

“…Among our cases, there were 1 GC and 3 NGC cases. This is slightly different from the cases reported by Owosho AA et al [27], which comprised 9 cases of GC and 4 cases of NGC.…”

Section: Discussioncontrasting

confidence: 88%

“…MCLs in the tongue base are even rarer. To the best of our knowledge, four cases have been reported, including our case and three cases from literature (Table 5) [17,27,40]. Generally, MCL patients have a median age of 60 years and a striking male predominance [42] .Three of the four cases of MCL including our case, occurred at the base of the tongue.…”

Section: Discussionmentioning

confidence: 52%

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Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status

Ren

Cheng

et al. 2020

Diagn Pathol

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Objectives: Non-Hodgkin's lymphoma (NHL) primarily derived from the base of the tongue, is rare. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and neck. This study describes the clinicopathological features of NHL in the tongue base and the status of HPV and EBV in these cases. Methods: Seven cases were identified from the Pathological Registry Database at Peking Union Medical College Hospital (PUMCH). The study utilized immunochemistry, in situ hybridization (ISH), and gene rearrangement to confirm the disease and and performed a clinical follow up for each case. Results: All 7 lymphomas were localized at the base of the tongue. Six of the cases exhibited tongue base masses with smooth surface membranes. One case presented as multiple deep ulcers. The most common histologic subtype was diffuse large B-cell lymphoma (DLBCL), which occurred in five cases. The other two cases were mantle cell lymphoma (MCL) and peripheral T cell lymphoma, not otherwise specified (PTCL, NOS). One of the DLBCL cases was positive for HPV DNA and diffusely expressed P16 protein. During the follow up period, the MCL patient and an elderly DLBCL patient died. The remaining five patients were alive through the end of follow up. Conclusions: Most lymphomas of the tongue base manifest as an endogenous mass without membranous change. The most common subtype of NHLs of the tongue base is DLBCL, and the occurrence at this site may have a good prognosis. With proper therapy, even late stage tongue base lymphomas can be suppressed and remain in remission.

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Section: Discussionsupporting

confidence: 92%

“…Among our cases, there were 1 GC and 3 NGC cases. This is slightly different from the cases reported by Owosho AA et al [27], which comprised 9 cases of GC and 4 cases of NGC.…”

Section: Discussioncontrasting

confidence: 88%

Section: Discussionmentioning

confidence: 52%

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Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status

Ren

Cheng

et al. 2020

Diagn Pathol

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“…The largest case series encountered twenty-six cases of large B-cell lymphoma in the base of tongue retrieved in 9 years, with the aim to illustrate a practical approach to the identification of prognostically important subtypes of large B-cell lymphomas [7]. 20 to 30% of Non Hodgkin lymphoma arise from extra nodal disease.…”

Section: Discussionmentioning

confidence: 99%

Primary Large B-Cell Lymphoma of the Base of Tongue

Busoni¹

2015

JOENTR

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“…Primary non-Hodgkin's lymphoma (NHL) of the tongue is very rare and accounts for 3% to 5% of all lymphoma subtypes, which corresponds to 1% of malignant tumors of the oral cavity [1][2][3] . Regarding epidemiology, they do not show a predilection for gender, affecting mostly patients between the fourth and eighth decades of life, with a mean age between 50 and 60 years 4 .…”

Section: Introductionmentioning

confidence: 99%