Large cell neuroendocrine carcinoma of the uterine cervix

Abstract

We report a case of large cell neuroendocrine carcinoma of the uterine cervix. A 33-year-old woman presented with a 4-month history of irregular vaginal bleeding and suspicious cervix. Transvaginal ultrasound showed a 3×3.8 cm cervical mass with a marked increase in the blood flow. MRI pelvis showed an exophytic tumour with left external iliac lymph node metastasis. Immunohistochemistry of the tumour cells showed strong positivity for the neuroendocrine markers synaptophysin and a very high Ki67 proliferation index. A diagnosis of high-grade large cell neuroendocrine carcinoma of the uterine cervix was made with FIGO stage IIA2. She was treated with chemotherapy and palliative radiotherapy but died 21 months after presenting. Neuroendocrine tumour of the uterine cervix is an extremely aggressive cancer with the late presentation—the need for a more rigorous treatment protocol as well as potential screening methods could improve outcomes for these patients.

Large-cell neuroendocrine carcinoma of the gynecologic tract: Prevalence, survival outcomes, and associated factors

“…After a disease-free period of 18 months, the patient experienced three consecutive recurrences in the kidney, breast, and adrenal gland, respectively, and survived for a total of 63 months. Habeeb and Habeeb ( 14 ) reported a case in which a patient with stage IIA2 disease died 21 months postoperatively despite treatment with CTX and palliative RT. In the current study, the median age of patients with cervical LCNEC was 48.48 (n=169).…”