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Objective This study aimed to assess the quality and readability of websites on chronic rhinosinusitis. Methods A total of 180 results from 3 different search engines regarding ‘chronic rhinosinusitis’, ‘sinusitis’ and ‘sinus infections’ were analysed for readability using the Flesch–Kincaid Grade Level, Flesch Reading Ease Score and Gunning Fog Index. The Discern tool was used to approximate information quality. Results From 180 total searches, 69 unique websites were identified. These had an average Flesch–Kincaid Grade Level of 9.75 (95 per cent confidence interval = 9.12–10.4), a Flesch Reading Ease Score of 45.0 (41.0–49.0) and a Gunning Fog Index of 13.7 (12.9–14.4), which equates to the average reading level of a college or university student. Discern scores were variable but consistently showed good-quality information. Conclusion Chronic rhinosinusitis information is of a high quality but is for a reading level higher than that of the average adult. Standardising patient information should ensure adequate comprehension and improve patient compliance.

In this study, solid dispersion using hydrophilic carriers (polyethylene glycols) and fast dissolving sugars (sorbitol and lactose) has been employed to enhance dissolution and hence the bioavailability of ibuprofen.Solid dispersions of different weight ratios (drug: carrier: fast dissolving sugars) have been prepared using fusion method.Microscopic images showed disappearance of specific features of ibuprofen, carriers and sugars in the solid dispersions.Release study of ibuprofen from prepared systems was performed in phosphate buffer pH 6.8; faster drug release was obtained from solid dispersions with high polyethylene glycol ratio and/ or from solid dispersions to which fast dissolving sugars has been added duringtheir preparations.The study also explored hydrogen bond interactions between polyethylene glycols and ibuprofen in the solid dispersions. FTIR spectroscopy confirmed intermolecular interaction at (2:1) drug to carrier mole ratio. This interaction was considered the most important factor in enhancing the dissolution of ibuprofen via solid dispersions.

We report a case of large cell neuroendocrine carcinoma of the uterine cervix. A 33-year-old woman presented with a 4-month history of irregular vaginal bleeding and suspicious cervix. Transvaginal ultrasound showed a 3×3.8 cm cervical mass with a marked increase in the blood flow. MRI pelvis showed an exophytic tumour with left external iliac lymph node metastasis. Immunohistochemistry of the tumour cells showed strong positivity for the neuroendocrine markers synaptophysin and a very high Ki67 proliferation index. A diagnosis of high-grade large cell neuroendocrine carcinoma of the uterine cervix was made with FIGO stage IIA2. She was treated with chemotherapy and palliative radiotherapy but died 21 months after presenting. Neuroendocrine tumour of the uterine cervix is an extremely aggressive cancer with the late presentation—the need for a more rigorous treatment protocol as well as potential screening methods could improve outcomes for these patients.