Large cell neuroendocrine carcinoma of the cervix associated with intestinal variant invasive mucinous adenocarcinoma

Hao, Hiroyuki; Itoyama, Masako; Taniguchi, Hiroshi; Tsujimoto, Masahiko; Hirota, Seiichi

doi:10.1111/j.1440-1827.2010.02606.x

Pathology International

2010

DOI: 10.1111/j.1440-1827.2010.02606.x

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Large cell neuroendocrine carcinoma of the cervix associated with intestinal variant invasive mucinous adenocarcinoma

Hiroyuki Hao¹,

Masako Itoyama²,

Hiroshi Taniguchi

et al.

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Cited by 5 publications

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“…About 40 cases of LCNEC have been reported and frequently coexist with a non-LCNEC component in the cervix (1,2). Few cervical LCNEC with coexisting invasive cervical adenocarcinoma are described in the literature (1,(3)(4)(5)(6), but because of this association, it has been suggested that LCNEC arises from the neuroendocrine cells present in the cervical adenocarcinoma (2,4,6).…”

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confidence: 94%

Monoclonality of Composite Large-Cell Neuroendocrine Carcinoma and Invasive Intestinal-type Mucinous Adenocarcinoma of the Cervix

Yasuoka

Tsujimoto

Ueda

et al. 2013

International Journal of Gynecological Pathology

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A rare case of mixed carcinoma of the cervix is reported, composed of a large-cell neuroendocrine carcinoma and an invasive intestinal-type mucinous adenocarcinoma. The large-cell neuroendocrine carcinoma was composed of solid nests, sheets, and trabeculae of medium-sized to large-sized cells, and was positive for chromogranin-A and CD56. The invasive intestinal-type mucinous adenocarcinoma showed sparsely scattered immunoreactivity for chromogranin-A. Using an X-chromosome clonality assay, these 2 components showed patterns of monoclonality. These results suggest that the large-cell neuroendocrine carcinoma may have arisen from the invasive mucinous adenocarcinoma.

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mentioning

confidence: 94%

Monoclonality of Composite Large-Cell Neuroendocrine Carcinoma and Invasive Intestinal-type Mucinous Adenocarcinoma of the Cervix

Yasuoka

Tsujimoto

Ueda

et al. 2013

International Journal of Gynecological Pathology

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Combined Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Gallbladder

Al-Brahim

Albannai

2012

Endocr Pathol

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Cervical Carcinomas With Neuroendocrine Differentiation: A Report of 28 Cases With Immunohistochemical Analysis and Molecular Genetic Evidence of Common Clonal Origin With Coexisting Squamous and Adenocarcinomas

Emerson

Michael²,

Wang³

et al. 2016

International Journal of Gynecological Pathology

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Cervical neuroendocrine carcinomas are rare, aggressive tumors and their immunohistochemical features and clonal relationship to coexisting tumors are incompletely described. Twenty-eight cases were identified (17 small cell, 9 large cell, and 2 mixed), 10 of which had an invasive squamous or adenocarcinoma component. Staining for synaptophysin, chromogranin A, TTF1, c-kit, CD44, and p16 was performed. Analyses for loss of heterozygosity (LOH) at 5 polymorphic microsatellite markers (D3S1300, D9S171, D11S914, D13S319, and TP53) and X-chromosome inactivation were performed. Of 17 cases with available blocks, 13 (76%) were synaptophysin+, 8 (47%) were chromogranin A+, 8 (47%) were TTF1+, 7 (41%) were c-kit+, and 6 (35%) were CD44+. Strong patchy or strong diffuse p16 staining was seen in all cases. LOH and X-chromosome inactivation analysis were performed for 17 cases, 8 of which had a coexisting squamous or adenocarcinoma component. Five of the 8 (63%) cases with 2 components showed allelic loss in both components. All 5 of these cases demonstrated identical LOH between the neuroendocrine and squamous or adenocarcinoma components. Nonrandom X-chromosome inactivation was seen in the neuroendocrine and other components in 4 of the 8 cases. In all 4 cases the pattern of inactivation was identical between the 2 components. Cervical neuroendocrine carcinomas have features similar to other extrapulmonary neuroendocrine carcinomas, including expression of TTF1, c-kit, and CD44. Consistent staining for p16 is also seen. Concordant genetic alterations support common clonal origin for neuroendocrine carcinomas with a coexisting squamous or adenocarcinoma component.

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Large cell neuroendocrine carcinoma of the cervix associated with intestinal variant invasive mucinous adenocarcinoma

Cited by 5 publications

References 8 publications

Monoclonality of Composite Large-Cell Neuroendocrine Carcinoma and Invasive Intestinal-type Mucinous Adenocarcinoma of the Cervix

Monoclonality of Composite Large-Cell Neuroendocrine Carcinoma and Invasive Intestinal-type Mucinous Adenocarcinoma of the Cervix

Combined Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Gallbladder

Cervical Carcinomas With Neuroendocrine Differentiation: A Report of 28 Cases With Immunohistochemical Analysis and Molecular Genetic Evidence of Common Clonal Origin With Coexisting Squamous and Adenocarcinomas

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