Large-cell neuroendocrine carcinoma of the cervix associated with cervical-type invasive adenocarcinoma: a report of case and discussion of histogenesis

Abstract

A case of cervical large-cell neuroendocrine carcinoma with mucinous-type cervical adenocarcinoma component adjacent to it is presented, and its histopathogenesis and clinical course are discussed under the light of the literature.

Expression of neuroendocrine markers in endometrial carcinomas — an immunohistochemical analysis

“…It might be assumed that neuroendocrine differentiation is a potential marker for aggressiveness. Recently, more attention has been concentrated on the fact that undifferentiated endometrial carcinomas can possess immunopositive reactions for neuroendocrine markers without typical morphological features of neuroendocrine carcinoma [5,14,17]. Tamura et al showed www.fhc.viamedica.pl positive reactions for neuroendocrine markers at 63% of undifferentiated cancers without typical morphological features [14].…”

“…Recently, articles have been published about the coexistence of undifferentiated cancers, serous and endometrioid, with focal positive immunoreactions for one or more neuroendocrine markers without morphological transformation into neuroendocrine cancer [5,[13][14][15][16][17]. This phenomenon is not well known and needs additional studies.…”

Monoclonality of Composite Large-Cell Neuroendocrine Carcinoma and Invasive Intestinal-type Mucinous Adenocarcinoma of the Cervix

“…About 40 cases of LCNEC have been reported and frequently coexist with a non-LCNEC component in the cervix (1,2). Few cervical LCNEC with coexisting invasive cervical adenocarcinoma are described in the literature (1,(3)(4)(5)(6), but because of this association, it has been suggested that LCNEC arises from the neuroendocrine cells present in the cervical adenocarcinoma (2,4,6).…”

Large cell neuroendocrine carcinoma of the cervix associated with intestinal variant invasive mucinous adenocarcinoma

“…It is also known that these NEC frequently coexist with a non‐NEC component in the cervix 3,4 . However, few cervical LCNEC with coexisting invasive cervical adenocarcinoma are described in the literature 2,3,5,6 . Furthermore, to the best of our knowledge, there are no reports describing NEC associated with intestinal variant invasive mucinous adenocarcinoma (INTAD) so far.…”