2018
DOI: 10.1371/journal.pone.0203199
|View full text |Cite
|
Sign up to set email alerts
|

Large conductance voltage- and calcium-gated potassium channels (BK) in cerebral artery myocytes of perinatal fetal primates share several major characteristics with the adult phenotype

Abstract: Large conductance voltage- and calcium-gated channels (BK) control fundamental processes, including smooth muscle contractility and artery diameter. We used a baboon (Papio spp) model of pregnancy that is similar to that of humans to characterize BK channels in the middle cerebral artery and its branches in near-term (165 dGa) primate fetuses and corresponding pregnant mothers. In cell-attached patches (K+pipette = 135 mM) on freshly isolated fetal cerebral artery myocytes, BK currents were identified by large… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(1 citation statement)
references
References 65 publications
0
1
0
Order By: Relevance
“…BK Ca channels of adult aortic smooth muscle cells remain open almost 10 times longer than the channels of fetal cells [ 86 ]. In addition, currents mediated by BK Ca channels in isolated smooth muscle cells of the middle cerebral artery of adult female baboons activated faster at lower membrane potential values than in fetal cells [ 87 ]. Probably the differences in the biophysical properties of the BK Ca channel between an adult and an immature organism correlate with the expression of the regulatory β1-subunit, which has a positive regulatory effect on BK Ca channel function [ 84 , 85 ].…”
Section: Developmental Alterations Of Potassium Channel Functioning In Arteries Of the Systemic Circulationmentioning
confidence: 99%
“…BK Ca channels of adult aortic smooth muscle cells remain open almost 10 times longer than the channels of fetal cells [ 86 ]. In addition, currents mediated by BK Ca channels in isolated smooth muscle cells of the middle cerebral artery of adult female baboons activated faster at lower membrane potential values than in fetal cells [ 87 ]. Probably the differences in the biophysical properties of the BK Ca channel between an adult and an immature organism correlate with the expression of the regulatory β1-subunit, which has a positive regulatory effect on BK Ca channel function [ 84 , 85 ].…”
Section: Developmental Alterations Of Potassium Channel Functioning In Arteries Of the Systemic Circulationmentioning
confidence: 99%