Symmetry analysis and self-similar forms of fluid flow and heat-mass transfer in turbulent boundary layer flow of a nanofluid Phys. Fluids 24, 092003 (2012) Detuned resonances of Tollmien-Schlichting waves in an airfoil boundary layer: Experiment, theory, and direct numerical simulation Phys. Fluids 24, 094103 (2012) Asymptotic expansion of the solution of the steady Stokes equation with variable viscosity in a two-dimensional tube structure J. Math. Phys. 53, 103702 (2012) Large-eddy simulation of turbulent channel flow using explicit filtering and dynamic mixed models Phys. Fluids 24, 085105 (2012) Additional information on Phys. Fluids Large eddy simulation (LES) is reported for both smooth and rough-wall channel flows at resolutions for which the roughness is subgrid. The stretched vortex, subgridscale model is combined with an existing wall-model that calculates the local friction velocity dynamically while providing a Dirichlet-like slip velocity at a slightly raised wall. This wall model is presently extended to include the effects of subgrid wall roughness by the incorporation of the Hama's roughness function U + (k + s∞ ) that depends on some geometric roughness height k s∞ scaled in inner variables. Presently Colebrook's empirical roughness function is used but the model can utilize any given function of an arbitrary number of inner-scaled, roughness length parameters. This approach requires no change to the interior LES and can handle both smooth and rough walls. The LES is applied to fully turbulent, smooth, and rough-wall channel flow in both the transitional and fully rough regimes. Both roughness and Reynolds number effects are captured for Reynolds numbers Re b based on the bulk flow speed in the range 10 4 -10 10 with the equivalent Re τ , based on the wall-drag velocity u τ varying from 650 to 10 8 . Results include a Moody-like diagram for the friction factor f = f(Re b , ), = k s∞ /δ, mean velocity profiles, and turbulence statistics. In the fully rough regime, at sufficiently large Re b , the mean velocity profiles show collapse in outer variables onto a roughness modified, universal, velocity-deficit profile. Outer-flow stream-wise turbulence intensities scale well with u τ for both smooth and rough-wall flow, showing a log-like profile. The infinite Reynolds number limits of both smooth and rough-wall flows are explored. An assumption that, for smooth-wall flow, the turbulence intensities scaled on u τ are bounded above by the sum of a logarithmic profile plus a finite function across the whole channel suggests that the infinite Re b limit is inviscid slip flow without turbulence. The asymptote, however, is extremely slow. Turbulent rough-wall flow that conforms to the Hama model shows a finite limit containing turbulence intensities that scale on the friction factor for any small but finite roughness. C 2012 American Institute of Physics.